HA 163N Polymorphism Probable for PF11

Current trending indicates a reportable potential for the K163N polymorphism on the Hemagglutinin of PF11. This change may enhance Vaccine Escape from the currently selected vaccine target candidate, CA/07 X181.

  • 33% probability of HA 163N (AAc) in PF11 within 90 days.
  • 25% probability of HA 163N (AAt) in PF11 within 120 days.
These probabilities will be updated as additional data is made public.  A rising potential also exists for additional HA 163E instances to be reported sporadically in the next 6 months.  Transparency at this stage of the pandemic is essential.  Release of sequences and clinical data of a finer detail and higher quantity will allow information-based decisions.

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