HA 263D Observed in Russia, Thailand and Japan

A/Tomsk/01, deposited in late July 2009, introduced the pandemic to 263D on Segment 4 (HA).

Since that novel introduction, four additional specimens have been deposited matching the Tomsk01 nucleotide sequence coding for 263D, spreading the geographical and time range.

• A/Thailand/CU-H9/2009      collected on 2009-06-17
• A/Thailand/CU-H276/2009   collected in 2009-07
• A/Thailand/CU-B938/2009   collected in 2009-08
• A/Wakayama/57/2009        collected on 2009-07-13

A/Thailand/271/2005 (H1N1) is a potential progenitor for this SNP and other recent pandemic acquisitions.

These sequences carry additional HA polymorphisms including 244I on ThaiCU-H9 matching Ancona02 and 405T on ThaiCU-H276 matching TorontoT5362.

You've noticed from our discussions that this HA domain has activity occurring in many parts of the world.  Residue 263 continues to rank as a primary watch position within ΣPF11 for our team.

Please visit GeneWurx.com for insight into the latest published studies.

SingaporeTLL10 HA demonstrates 3 H5N1 amino acids: 206T, 226R and 261V

A/Singapore/TLL10, sample 2009-07-27, is a first on the PF11 background.

SingTLL10 is the first on PF11 to carry 261V, though movement at that position has been documented in Italy51 and Italy53 with 261G and a downstream 263D entered PF11 with Tomsk01 and then continued with 3 Thai sequences (ThaiCU-H9, ThaiCU-B938, ThaiCU-H276).

261V is wild type for H5N1 including Anhui02 that carries all three of the amino acid changes mentioned here for SingTLL10:

• 206T
• 226R
• 261V

H5N1 Anhui02 is a potential donor for 296H that seems to track primarily to 206T bearing strains.

This expansion deeper into Southern Asia with 226R brings the number of sequences bearing the H5N1 match into double digits.  RBD changes matching H5N1 demand scrutiny.  For background, please read an earlier 226R Study.

Please visit GeneWurx.com for insight into the latest published studies.

United States (NorthEast) HA Diversity at 206; 296H Intra-Segment Exclusivity Continues

A pair of sequences each from Pennsylvania and Rhode Island deposited at GenBank on 2009-09-10 demonstrate continued Hemagglutinin diversity within single geographies and similar time frames.  Multiple PF11 sub-clades in the United States and worldwide show ongoing human fitness and co-existance ability producing a Hydra Effect.

• A/Pennsylvania/06 (PA06) demonstrates 206S and 296H
• A/Pennsylvania/14 (PA14) demonstrates 206T and 296Q,  218X

• A/Rhode Island/07 (RI07) demonstrates 206S and 296H
• A/Rhode Island/08 (RI08) demonstrates 206T and 296Q

• A/Massachusetts/10 (MA10) demonstrates 206S and 296H
• A/Indiana/17 (IN17) demonstrates 206S and 296H

As of this moment, the Intra-Segment Exclusivity between 296H and 206T continues on the PF11 background.  Pennsylvania, Rhode Island and Massachusetts have observed candidate donors of 206T; however, the genetic diversity of 206S with 296H remains in those states and with similar occassion in many international locales.

The highly correlative 2E is found in the 4 referenced 296H Hemagglutinins in this United States deposit.

PA06, RI07, MA10 and IN17 are an exact nucleotide match to A/Italy/127 from 2009-06-17, the only PF11 sequence in the world to carry the 256L on Neuraminidase (with 106I/248N). 

The rare 256L is originally found on the 1918 Brevig Mission sequence.  256L candidate donors include many H3N2 2008 Seasonal Influenza specimens and several H1N2 2008 swine from Oklahoma and Texas.

RI07 on Segment 6 (Neuraminidase) is an exact nucleotide match to a pivotal sequence that will be detailed later from Germany, A/Bayern/66.  The IN17 NA also tracks to RI07 and Bayern66 at 1409 of 1410 nucleotide positions.  Bayern66 is strongly related to the HA of the Russian and Northern European heralds of HA:226R, Omsk01, Ekaterinburg01 and Finland553 and to the HA of Tomsk01.

Please visit GeneWurx.com for insight into the latest published studies.