United States (NorthEast) HA Diversity at 206; 296H Intra-Segment Exclusivity Continues

A pair of sequences each from Pennsylvania and Rhode Island deposited at GenBank on 2009-09-10 demonstrate continued Hemagglutinin diversity within single geographies and similar time frames.  Multiple PF11 sub-clades in the United States and worldwide show ongoing human fitness and co-existance ability producing a Hydra Effect.

• A/Pennsylvania/06 (PA06) demonstrates 206S and 296H
• A/Pennsylvania/14 (PA14) demonstrates 206T and 296Q,  218X

• A/Rhode Island/07 (RI07) demonstrates 206S and 296H
• A/Rhode Island/08 (RI08) demonstrates 206T and 296Q

• A/Massachusetts/10 (MA10) demonstrates 206S and 296H
• A/Indiana/17 (IN17) demonstrates 206S and 296H

As of this moment, the Intra-Segment Exclusivity between 296H and 206T continues on the PF11 background.  Pennsylvania, Rhode Island and Massachusetts have observed candidate donors of 206T; however, the genetic diversity of 206S with 296H remains in those states and with similar occassion in many international locales.

The highly correlative 2E is found in the 4 referenced 296H Hemagglutinins in this United States deposit.

PA06, RI07, MA10 and IN17 are an exact nucleotide match to A/Italy/127 from 2009-06-17, the only PF11 sequence in the world to carry the 256L on Neuraminidase (with 106I/248N). 

The rare 256L is originally found on the 1918 Brevig Mission sequence.  256L candidate donors include many H3N2 2008 Seasonal Influenza specimens and several H1N2 2008 swine from Oklahoma and Texas.

RI07 on Segment 6 (Neuraminidase) is an exact nucleotide match to a pivotal sequence that will be detailed later from Germany, A/Bayern/66.  The IN17 NA also tracks to RI07 and Bayern66 at 1409 of 1410 nucleotide positions.  Bayern66 is strongly related to the HA of the Russian and Northern European heralds of HA:226R, Omsk01, Ekaterinburg01 and Finland553 and to the HA of Tomsk01.

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