HA 230I Receptor Binding Domain Polymorphism Probable for PF11

Current trending indicates a reportable potential for the M230I polymorphism on the Hemagglutinin of PF11. This Receptor Binding Domain change may enhance Vaccine Escape from the currently selected vaccine target candidate, CA/07 X181.

• 25% probability of HA 230I in PF11 RBS within 90 days.
• 33% probability of HA 230I in PF11 RBS within 180 days.

These probabilities will be updated as additional data is made public.  Transparency at this stage of the pandemic is essential.  Release of sequences and clinical data of a finer detail and higher quantity will allow information-based decisions.

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