2009-11-02

225E on 45% of Catalonia HA Deposit from August and September

The Hospital Clinic of Barcelona, Spain deposited 21 HA/NA/MP segments at GenBank on Friday.  The group as a whole demonstrates significant diversity and the velocity of change at residue 225 in the Receptor Binding Domain is remarkable. 

The samples are primarily from August and September, as late as 2009-09-30.  One sample is earlier, from July.  9 of 20 specimens (45%) in this deposit that were sampled in August and September demonstrate 225E paired with 206T.  As of this accumulation, Spain shows 31 instances of 225E with no 206S and 3 instances of 225G with 206T.  Additionally, several unique faces enter  ΣPF11 with the Hospital Clinic's latest deposit. 

HA Amino Acid Codings to 3 Novel Polymorphisms and 6 Rare Signals
  •    35I
  •   71G
  •  142T
  •  188N
  •  193G
  •  225E
  •  240R
  •  298V
  •  373H
35I
CatS1305, CatS1411, CatS1414, CatS1435.
Rare to ΣPF11.
Found in 6 other sequences including recent TamiFlu-Resistant US sequence, A/Texas/47.
Progenitors may include:
H5N1 Avian
H5N1 Human

71G
CatS1436.
NY80 is the singular ΣPF11 peer.

142T
CatS1411.
Novel to ΣPF11.

188N
CatS1369.
CatS1187 and Niigata700 are the lone ΣPF11 peers.

193G
CatS1384.
Novel to ΣPF11.

225E
CatS1300, CatS1304, CatS1331, CatS1333, CatS1350, CatS1369, CatS1379, CatS1436, CatS1453.
Presently velocitised within recent ΣPF11.

240R
CatS1436.
Novel to ΣPF11.
Progenitors may include:
Zhuhai/790/2008
H1N2 Swine

298V
CatS1369, CatS1436.
Unique to Catalonia within ΣPF11.
CatNS2001, CatNS2008, CatS1237, CatS1248, CatS1286.

373H
CatS1353.
Unique to Catalonia within ΣPF11.
CatS1285.

Neuraminidase Triple Combination
106I, 248D, 286S   20 Sequences
106V, 248D, 286S  CatS1369.

The pattern shown by CatS1369 is found in 4 other instances within ΣPF11.  Three of those were very early in the pandemic and the most recent is A/Toronto/R8564 from a 7F in early July.

This Neuraminidase group displays some variety with exception in three sequences.

NA Amino Acid Codings to 4 Polymorphisms
  •  321V
  •  369T
  •  386D
  •  395R
321V
CatS1402.

369T
CatS1307, CatS1402.

386D
CatS1384.

395R
CatS1402.


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