What would you think if I told you that syn413K was traveling with another silent companion . . . who lives on a different gene segment? Norway3364 is the only recent sequence from that country with a published Neuraminidase segment. And this time, they gave us a very useful one. Cross segment linking is occurring regularly in ΣPF11 and this sequence provides an opportunity to examine one pair.
Norway3364 carries HA syn413K and NA syn407V. This particular version of 407V is widespread in H5N1 and the cross-segment pair is also noted under the virulent serotype.
Cross-Linked HA and NA from Norway to the Ukraine
- HA:syn413K encoded from A1281G, AAa->AAg *
- NA:syn407V encoded from T1221C, GTt->GTc *
A limited inspection demonstrates a wide range for this paired set of travelers. The following list is not comprehensive, but is a representative geographic sample of other sequences that carry the pair. Any attempt at a comprehensive study will only result in disappointment as you'll find that many sequences with syn413K have no NA to evaluate and many sequences with syn407V have no related HA. Patterns do not precisely define themselves without data, but the range is impressive even with the limited dataset.
Norway, the Ukraine, Sweden, Spain, Russia, the United States and Singapore are identified in this sequence range.
- LvivN2
- LvivN6
- TernopilN10
- TernopilN11
- Norway3364
- CatS1096
- CatS1162
- CatS1181
- CatS1268
- CatS1402
- CatS1501
- CatS1687
- CatS1748
- CatS1751
- CatS1761
- SingaporeON1156
- Stockholm31
- Omsk02
- NY3702
- NY3715
- NY3828
- RhodeIsland08
We have provided 22 examples so that random mutation and / or spontaneous mutation proponents may think before answering the probabilities of these outcomes under those outdated frameworks.
