The United States with a population of 300 million reached 1,000 official fatalities roughly 6 months after the initial deaths were recorded and the new viral reservoir was identified. We remind you that the Ukraine has a population roughly one-sixth (17%) of the United States at just under 50 million citizens.
- 1,000 deaths from 300 million in roughly 175 days = United States
- 1,000 deaths from 50 million in roughly 75 days = Ukraine
As GeneWurx.com is tracking the emergence of Receptor Binding Site polymorphisms and epitope acquisitions in relation to published epidemiological and clinical accounts, the Ukraine continues to offer the most comprehensive picture and the most up-to-date information. Coupled with the recent publication of sequences from Russia and Turkey that correspond in various areas with the Ukraine’s early sequence deposit (225 diversity, HA syn413K and NA syn407V) and the additional interlacing of that same superset of related sequences (Ukraine, Russia, Turkey) with Spain, US and Chinese PF11 and H5N1 genetic markers, the present acceleration of cases and deaths in the Ukraine should be closely monitored.
The most recent sequences published from the Ukraine are partial and were sampled in November just as the wave reached 1 million cases. Slightly under 4 million cases are presently reported. 4 million cases should generate more than the 23 partial sequences now published?
The most recent sample from Kiev yielded the nucleotide sequence of RVT at amino acid 225 potentially coding for 6 distinct amino acid values. R and V are Ambiguity Codes indicating mixed peaks on the sequencing trace. The R at the first base of the codon demonstrates that two values were documented. The V at the second base of the codon indicates that three distinct values were detected.
R = A and G
V = A, C and G
T = T
AAT = 225N
ACT = 225T
AGT = 225S
GAT = 225D wt
GCT = 225A
GGT = 225G
A sample from Chernihiv yielded the nucleotide sequence of RRT coding for 4 potential values at amino acid 225. The R at the first base of the codon demonstrates that two values were documented. The R at the second base of the codon indicates that the same two distinct values were detected there as well.
R = A and G
R = A and G
T = T
AAT = 225N
AGT = 225S
GAT = 225D wt
GGT = 225G
The most recent group of sequences (November) continues a strong correlation to the early cross segment linkage background and persists in accelerated genetic variation at position 225. The two sequences that demonstrate Receptor Binding Site diversity show significant single amino acid position variation on a level unprecedented in ΣPF11.
Outside the RBS, this Ukraine background for presumably fatal cases appears to be strikingly stable, balancing strong genetic throw against very minimal position variation (225) arguably for immune escape and vaccine escape. This emerging sub-clade may represent a new base point for the virus in that region, becoming a universal donor of sorts to the surrounding countries as seen in Russia and Turkey.
Just as PF11 has replaced seasonal influenza around the world, this cross segment linkage background appears to be supplanting the various versions from ΣPF11 in this region. If the cross linked silent Ukraine changes are correlated as a platform for RBS diversity at 225 and 225G/225N/225E are associated with fatality cases around the world, future fatality increases may be predictable based on the geographic extent of that cross linked background (HA syn413K and NA syn407V).
Will the Ukraine be historically noted in some epidemiology paper of the distant future as the incubator for a new and powerful sub-clade under ΣPF11? Is that the best we can do? Or will we take the present trend for the full value of the data and proact today by illuminating the lab day and night with the best gear, the most definitive techniques and the brightest scholars, driving for an actionable answer?
The death count nears 1,000 in the Ukraine over a very short time span and the sequences from that country and neighboring areas indicate hyper-morphic behaviour at amino acid position 225. No interpretation required.
Gather and Solve.
