Ukraine Predictions Found in 14 Recent Catalonia Sequences; 2 Others from Spain on Cross-Linked Background

The Hospital Clinic of Spain continues a trend of providing high quality sequences representing a cross section of their general population of cases.  Today sequences from 12 samples taken from mid to late December of 2009 were published publicly at GenBank. 

The results may define a late year inflection point in ΣPF11.  A one-to-one ratio exists between sequences bearing 225E RBD changes and sequences with the cross segment linkage of HA syn413K and NA 407V.  Only two of each are present in this set of 12 sequences. 

And the 225E sequences add to a list of 12 other very recent Spanish sequences all published after 2009-11-09 that carry a combination predicted to be found if a representative sample of 100 Ukraine sequences were to be produced . . . that representative cross-section for the Ukraine has yet to be published.  Pandemic Influenza is undaunted by our failure to properly measure and this reservoir continues the genetic acquisition cycle as is evidenced by the data from Spain and countries neighboring the Ukraine. 

We expected a small count (1 to 2) of sequences in the Ukraine to have the quadruple HA combination of 2E/206T/225E/298V.  Deposits after that prediction from Spain, including this set today, demonstrate the somewhat accurate direction of that prediction and the rapid emergence of a regional sub-clade.  Though each of these 14 sequences was published with the beginning truncated, the triple combination of 206T/225E/298V is verifiable.  Catalonia/S2143 and Catalonia/S2099 enter the list from today's Spanish deposit.

• HA CatS2143 sampled 2009-12-21
• HA CatS2099 sampled 2009-12-14
• HA CatS1947 sampled 2009-11-23
• HA CatS1944 sampled 2009-11-23
• HA CatS1835 sampled 2009-11-16
• HA CatS1830 sampled 2009-11-13
• HA CatS1829 sampled 2009-11-13
• HA CatS1828 sampled 2009-11-12
• HA CatS1761 sampled 2009-11-09
• HA CatS1758 sampled 2009-11-09
• HA CatS1748 sampled 2009-11-09
• HA CatS1674 sampled 2009-11-02
• HA CatS1672 sampled 2009-11-02
• HA CatS1604 sampled 2009-10-26

Cross-Linked Silent HA and NA Polymorphisms Correlated with Fatal 225G Cases in the Ukraine and Russia are found on two of the sequences from today's deposit.

• HA and NA CatS2120 with multiple swine markers
• HA and NA CatS2151 with swine markers and 165N matching TamiFlu Resistant CatNS7632 and Russian 225G Salekhard01

These cross-linked backgrounds are transmitting in the most recent sequences that are on file.  Determining the exact relationship and ratio changes between 225E and these apparently antagonistic cross-linked backgrounds with the silent changes may be the key to understanding the acceleration and regionality of 225G emergence.

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