225G Sequence from Pennsylvania Extends Sub-Clade with Fatality Markers from Russia and Brasil

Last Updated 2011-03-29

January to August 2010 Expansion of One Hydra

On 2010-08-07 and the following weeks, GeneWurx discussed the spread of one remarkable Hydra across the US, Germany and the Ukraine.  HA 230I is represented in this sub-clade on a sequence from the US state of Minnesota.  HA 225G (GgT) now enters this sub-clade in the US state of Pennsylvania.  The sub-clade appears to be one of several that are permissive to a combination of 225G (GgT) and 230I within post-pandemic H1N1.

On 2010-09-24, the US CDC released a set of sequences at GISAID that included six from the United States.  Pennsylvania07_2010_08_12 was sampled from a 24 year old female.  No clinical information is provided, nor outcome. 

The sequence carries 13 polymorphisms on the HA alone and typifies the rapid genetic acquisition that continues on the most current samples in the United States.  Six of those changes place the sequence with 11 other cases across the United States, the Ukraine and Germany.

Follow 6 HA polymorphisms (3 silent) tracing onto this 12th sequence through the 8th distinct geographic location:

34D, 165N, 189T, syn213F, syn305K, syn346G.

Five of the six polymorphisms are found in animal influenza reservoirs (zoonotic) and the sixth shares nucleotide homology with recognised zoonotic reservoirs.  Is this another strain linking the US to flu strains from the Ukraine, India or Russia?

. . . . Pennsylvania07_2010_08_12 (
. . . . . . . . 34D,
. . . . . . . . syn118E,
. . . . . . . . 140T,
. . . . . . . . 165N,
. . . . . . . . 189T,
. . . . . . . . syn213F,
. . . . . . . . 225G (GgT),
. . . . . . . . 275I,
. . . . . . . . syn287G,
. . . . . . . . syn305K,
. . . . . . . . syn329S,
. . . . . . . . syn346G,
. . . . . . . . 451E [Unique to Japan])

Please refer to additional studies for further genetic analyses, including the survey on amino acid revisions potentially related to Vaccine Escape.  A hyper-morphic, TamiFlu-resistant sequence from the state of Washington in Spring 2010 has recently been profiled with similar zoonotic influences.

Previous Study on this Topic:

• 2010-08-07 HA Spreads Across US and Travels to the Ukraine Again

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