The polymorphism, Q296H, was found in the 11 year old female death in SaoPaulo43812, is widely conserved in the Northeastern US, is conserved in Italy and is found in Northwestern Europe.
This change has moved into Singapore, a major gateway to the world. Singapore shares the title of Busiest Port in the World with Shanghai in different categories. 296H emerged in Singapore in one of the four sequences sampled on 2009-06-14 and deposited yesterday, A/Singapore/TLL54. No other segments for this sample are on file for review.
SingaporeTLL54
- 2E
- 35I
- 66E
- 296H
The 296H change is rare on PF11 sequences in Asia with only 2 matches in China (Shanghai143T, Shandong1) and 1 in Japan (Tokushima1). On the PF11 background, only 31 sequences across the globe now carry 296H.
New York obviously provides a substantial international vector from the airports and seaports. Shanghai and Singapore vector air and sea extensively. The Italian port of Ancona provides a significant trans-Adriatic ferry service.
We suggest tracking for interplay between 296H and the recent RBD changes noted in QC1 and QC2.