Sweden Deposits Triple-Claded Virus, TamiFlu-Resistant Via Two Effectors

Sequences discussed in this analysis are variously stored publicly at GenBank and at GISAID. We gratefully acknowledge the authors, originating and submitting laboratories of the sequences from GenBank and from GISAID’s EpiFlu™ Database on which this research is based. A GISAID-generated list is detailed in a linked PDF for completeness in citation.

Publish Date : 2013-04-05
Last Update : 2013-04-05

On 2013-04-05, the Swedish Institute for Infectious Disease Control released a human pH1N1 sequence at GISAID from an immunocompromised child.  The viral Hemagglutinin displays extreme CladeCrossing tendencies adding 186P and 189T to a recently emergent Clade2:188T background.  TamiFlu Resistance is delineated by two markers, NA 247N and 275Y.

. . . . SwedenUppsala4_4M_2013_04_01_TmX (

. . . . . . . . GISAID HA EPI440476

. . . . . . . . GISAID Isolate EPI_ISL_138979

. . . . . . . . 22 Polymorphisms (11 Amino and 11 Silent)

. . . . . . . . syn#4Y (TAc),

. . . . . . . . syn71E (GAg),

. . . . . . . . 75A,

. . . . . . . . syn77S (AGt),

. . . . . . . . 100N,

. . . . . . . . 176I,

. . . . . . . . syn179L (CTg),

. . . . . . . . 186P,

. . . . . . . . 188T,

. . . . . . . . 189T,

. . . . . . . . 237I,

. . . . . . . . 286E,

. . . . . . . . syn296Q (CAa),

. . . . . . . . syn308K (AAg),

. . . . . . . . syn333F (TTc),

. . . . . . . . syn338G (GGc),

. . . . . . . . syn372Q (CAa),

. . . . . . . . 377K,

. . . . . . . . syn396V (GTg),

. . . . . . . . syn448L (TTg),

. . . . . . . . 454N,

. . . . . . . . 502K)

. . . . SwedenUppsala4_4M_2013_04_01_TmX (

. . . . . . . . GISAID NA EPI440477

. . . . . . . . GISAID Isolate EPI_ISL_138979

. . . . . . . . 18 Polymorphisms (10 Amino and 8 Silent)

. . . . . . . . 44S,

. . . . . . . . 80M,

. . . . . . . . 106V,

. . . . . . . . syn176S (TCg),

. . . . . . . . 200S,

. . . . . . . . syn204A (GCg),

. . . . . . . . syn205V (GTa),

. . . . . . . . syn209N (AAt),

. . . . . . . . syn240T (ACc),

. . . . . . . . 241I,

. . . . . . . . 247N,

. . . . . . . . 275Y,

. . . . . . . . syn310L (tTG),

. . . . . . . . 369K,

. . . . . . . . syn377P (CCa),

. . . . . . . . syn378N (AAt),

. . . . . . . . 448I,

. . . . . . . . 452I)

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pH1N1 Influenza Hemagglutinin & Neuraminidase Segments elucidated at 2013-04-05-08_09_08_355700 by GeneWurx see.PolyDetector v0, Copyright 2007-2013.

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