Another distinct geographic area is inserted into the January to August 2010 Expansion of the emerging 230I-Permissive PF11 Hydra.
From 2010-08-07 through 2010-09-27, GeneWurx discussed the spread of one remarkable Hydra across the US, Germany and the Ukraine. HA 230I is represented in this sub-clade on a sequence from the US state of Minnesota. HA 225G (GGt) entered the sub-clade in the US state of Pennsylvania. The sub-clade appears to be one of several that are permissive to a combination of 225G (GGt) and 230I within post-pandemic H1N1.
On 2010-10-14, the UK National Institute for Medical Research released a set of sequences at GISAID, primarily from
The sequence carries 9 polymorphisms on the HA alone and typifies the rapid genetic acquisition. Six of those changes place the sequence with 12 other cases across the United States, the Ukraine and Germany.
Follow 6 HA polymorphisms (3 silent) tracing onto this 13th sequence through the 9th distinct geographic location:
34D, 165N, 189T, syn213F, syn305K, syn346G.
Five of the six polymorphisms are found in animal influenza reservoirs (zoonotic) and the sixth shares nucleotide homology with recognised zoonotic reservoirs. Does this Hydra link the US to flu strains from the Ukraine, India or Russia?
. . . . CapeTown29_24M_2010_06_08 (
. . . . . . . . 34D,
. . . . . . . . 165N,
. . . . . . . . 189T,
. . . . . . . . syn213F,
. . . . . . . . 275I,
. . . . . . . . syn287G,
. . . . . . . . syn305K,
. . . . . . . . syn346G,
. . . . . . . . 382I [NY2372_2010_01_20
. . . . . . . . . . . . . . . . . with 128D, 233H, 273A, syn283Q,
. . . . . . . . . . . . NewZealandWaikato2_2010_01_04
. . . . . . . . . . . . . . . . . with 233H, syn283Q,
. . . . . . . . . . . . NY_INS317_2009_12_17
. . . . . . . . . . . . . . . . . with 233H, 273A, syn283Q,
. . . . . . . . . . . . Hawaii28_2009_10_10
. . . . . . . . . . . . . . . . . with 159D,
. . . . . . . . . . . . Cameroon357_2009_08_08
. . . . . . . . . . . . . . . . . with 225E])
Please refer to additional studies for further genetic analyses, including the survey on amino acid revisions potentially related to Vaccine Escape. A hyper-morphic, TamiFlu-resistant sequence from the state of Washington in Spring 2010 has recently been profiled with similar zoonotic influences.
Previous Study on this Topic:
- 2010-08-07 HA Spreads Across US and Travels to the Ukraine Again
- 2010-09-27 225G Sequence from Pennsylvania Extends Sub-Clade with Fatality Markers from Russia and Brasil
