Japan Demonstrates 5 TamiFlu Resistant Sequences and 5 Vaccine Escape Markers

Sequences discussed in this analysis are variously stored publicly at GenBank and at GISAID. We gratefully acknowledge the authors, originating and submitting laboratories of the sequences from GenBank and from GISAID’s EpiFlu™ Database on which this research is based. A GISAID-generated list is detailed in a linked spreadsheet for completeness in citation.

Last Update
2011-07-20

On 2011-06-24, the National Institute of Infectious Diseases (NIID) of Japan published sequences of 50 pH1N1 segments (30 HA and 20 NA) at GISAID with no clinical outcome noted, but with manifestations of drug resistance markers related to TamiFlu Resistance spread across multiple geographies.  All HA segments are fragments.

216 HA Polymorphisms across 71 codons for an average of 7.2 changes per HA.
142 NA Polymorphisms across 48 codons for an average of 7.1 changes per NA.
----
358 Total Polymorphisms.


Vaccine Escape Modulators: 5

HA 156E (1)
HA 157E mix wt (1)
HA 158E mix wt (2)

TamiFlu Resistance (Genetic): 5 sequences

JapanHiroshima55_2011_02_09_TmX
JapanOsaka52_2011_02_04_TmX
JapanNiigata214_2011_02_04_TmX
JapanShizuoka37_2011_02_03_TmX
JapanOkinawa40_2011_01_25_TmX

Sequences

Clade 2:
188T

. . . . JapanHiroshima55_2011_02_09_TmX (
. . . . . . . . GISAID HA EPI320266
. . . . . . . . 6 Polymorphisms (3 Amino and 3 Silent)
. . . . . . . . syn10Y (TAc),
. . . . . . . . syn34N (AAt),
. . . . . . . . 146G,
. . . . . . . . 188T,
. . . . . . . . 200T,
. . . . . . . . syn338G (GGc),
. . . . . . . . HA Truncated after aa348)

. . . . JapanHiroshima55_2011_02_09_TmX (
. . . . . . . . GISAID NA EPI320265
. . . . . . . . 7 Polymorphisms (5 Amino and 2 Silent)
. . . . . . . . 44S,
. . . . . . . . syn240T (ACc),
. . . . . . . . 241I,
. . . . . . . . 275Y,
. . . . . . . . 369K,
. . . . . . . . syn377P (CCa),
. . . . . . . . 415M)

. . . . Niigata214_2011_02_04_TmX (
. . . . . . . . GISAID HA EPI320247
. . . . . . . . 11 Polymorphisms (5 Amino and 6 Silent)
. . . . . . . . #6M,
. . . . . . . . syn34N (AAt),
. . . . . . . . 86P mix wt,
. . . . . . . . syn122K (AAa),
. . . . . . . . 146G,
. . . . . . . . 188T,
. . . . . . . . 200T,
. . . . . . . . syn240G (GGg),
. . . . . . . . syn258F (TTt),
. . . . . . . . syn299H (CAc),
. . . . . . . . syn338G (GGc),
. . . . . . . . HA Truncated after aa348)

. . . . Niigata214_2011_02_04_TmX (
. . . . . . . . GISAID NA EPI320246
. . . . . . . . 9 Polymorphisms (5 Amino and 4 Silent)
. . . . . . . . 44S,
. . . . . . . . 71D mix wt,
. . . . . . . . syn210G (GGa),
. . . . . . . . syn240T (ACc),
. . . . . . . . 241I,
. . . . . . . . 275Y,
. . . . . . . . 369K,
. . . . . . . . syn377P (CCa),
. . . . . . . . syn378N (AAt))

. . . . JapanOsaka52_2011_02_04_TmX (
. . . . . . . . GISAID HA EPI320269
. . . . . . . . 6 Polymorphisms (2 Amino and 4 Silent)
. . . . . . . . syn34N (AAt),
. . . . . . . . syn42G (GGa),
. . . . . . . . 188T,
. . . . . . . . 200T,
. . . . . . . . syn296Q (CAa),
. . . . . . . . syn338G (GGc),
. . . . . . . . HA Truncated after aa348)

. . . . JapanOsaka52_2011_02_04_TmX (
. . . . . . . . GISAID NA EPI320268
. . . . . . . . 7 Polymorphisms (5 Amino and 2 Silent)
. . . . . . . . 44S,
. . . . . . . . syn240T (ACc),
. . . . . . . . 241I,
. . . . . . . . 275Y,
. . . . . . . . 369K,
. . . . . . . . syn377P (CCa),
. . . . . . . . 415M)

. . . . JapanShizuoka37_2011_02_03_TmX (
. . . . . . . . GISAID HA EPI320245
. . . . . . . . 7 Polymorphisms (4 Amino and 3 Silent)
. . . . . . . . syn10Y (TAc),
. . . . . . . . syn34N (AAt),
. . . . . . . . 71D,
. . . . . . . . 146G,
. . . . . . . . 188T,
. . . . . . . . 200T,
. . . . . . . . syn338G (GGc),
. . . . . . . . HA Truncated after aa348)

. . . . JapanShizuoka37_2011_02_03_TmX (
. . . . . . . . GISAID NA EPI320244
. . . . . . . . 8 Polymorphisms (4 Amino and 4 Silent)
. . . . . . . . 44S,
. . . . . . . . syn240T (ACc),
. . . . . . . . 241I,
. . . . . . . . 275Y,
. . . . . . . . 369K,
. . . . . . . . syn377P (CCa),
. . . . . . . . syn382G (GGa),
. . . . . . . . syn434N (AAt))

. . . . JapanIwate1011_2011_01_26 (
. . . . . . . . GISAID HA EPI320255
. . . . . . . . 9 Polymorphisms (4 Amino and 5 Silent)
. . . . . . . . syn10Y (TAc),
. . . . . . . . syn34N (AAt),
. . . . . . . . 146G,
. . . . . . . . 158E mix wt,
. . . . . . . . syn161Y (TAt),
. . . . . . . . 188T,
. . . . . . . . 200T,
. . . . . . . . syn317L (tTG),
. . . . . . . . syn338G (GGc),
. . . . . . . . HA Truncated after aa348)

. . . . JapanOkinawa40_2011_01_25_TmX (
. . . . . . . . GISAID HA EPI320274
. . . . . . . . 4 Polymorphisms (2 Amino and 2 Silent)
. . . . . . . . 100N,
. . . . . . . . syn179L (CTg),
. . . . . . . . 188T,
. . . . . . . . syn338G (GGc),
. . . . . . . . HA Truncated after aa348)

. . . . JapanOkinawa40_2011_01_25_TmX (
. . . . . . . . GISAID NA EPI320273
. . . . . . . . 7 Polymorphisms (3 Amino and 4 Silent)
. . . . . . . . syn162P (CCc),
. . . . . . . . syn240T (ACc),
. . . . . . . . 241I,
. . . . . . . . 275Y,
. . . . . . . . 369K,
. . . . . . . . syn377P (CCa),
. . . . . . . . syn416D (GAc))

. . . . JapanHokkaido32_2011_01_25 (
. . . . . . . . GISAID HA EPI320237
. . . . . . . . 9 Polymorphisms (3 Amino and 6 Silent)
. . . . . . . . syn10Y (TAc),
. . . . . . . . syn34N (AAt),
. . . . . . . . syn98F (TTt),
. . . . . . . . syn122K (AAa),
. . . . . . . . 146G,
. . . . . . . . 188T,
. . . . . . . . 200T,
. . . . . . . . syn262R (AGg),
. . . . . . . . syn338G (GGc),
. . . . . . . . HA Truncated after aa348)

. . . . JapanHyogo4012_2011_01_25 (
. . . . . . . . GISAID HA EPI320241
. . . . . . . . 7 Polymorphisms (4 Amino and 3 Silent)
. . . . . . . . 17G,
. . . . . . . . syn34N (AAt),
. . . . . . . . 188T,
. . . . . . . . 197D mix wt,
. . . . . . . . 200T,
. . . . . . . . syn296Q (CAa),
. . . . . . . . syn338G (GGc),
. . . . . . . . HA Truncated after aa348)

. . . . JapanHyogo4012_2011_01_25 (
. . . . . . . . GISAID NA EPI320240
. . . . . . . . 7 Polymorphisms (4 Amino and 3 Silent)
. . . . . . . . 44S,
. . . . . . . . syn126P (CCt),
. . . . . . . . syn240T (ACc),
. . . . . . . . 241I,
. . . . . . . . 369K,
. . . . . . . . syn377P (CCa),
. . . . . . . . 415M)

. . . . JapanOsaka45_2011_01_21 (
. . . . . . . . GISAID HA EPI320264
. . . . . . . . 7 Polymorphisms (3 Amino and 4 Silent)
. . . . . . . . syn10Y (TAc),
. . . . . . . . syn34N (AAt),
. . . . . . . . syn130D (GAt),
. . . . . . . . 146G,
. . . . . . . . 188T,
. . . . . . . . 200T,
. . . . . . . . syn338G (GGc),
. . . . . . . . HA Truncated after aa348)

. . . . JapanShizuokaC8_2011_01_20 (
. . . . . . . . GISAID HA EPI320235
. . . . . . . . 6 Polymorphisms (3 Amino and 3 Silent)
. . . . . . . . syn34N (AAt),
. . . . . . . . 188T,
. . . . . . . . 200T,
. . . . . . . . 241G,
. . . . . . . . syn296Q (CAa),
. . . . . . . . syn338G (GGc),
. . . . . . . . HA Truncated after aa348)

. . . . JapanShimane57_2011_01_19 (
. . . . . . . . GISAID HA EPI320254
. . . . . . . . 8 Polymorphisms (4 Amino and 4 Silent)
. . . . . . . . syn10Y (TAc),
. . . . . . . . syn34N (AAt),
. . . . . . . . syn130D (GAt),
. . . . . . . . 146G,
. . . . . . . . 157E mix wt,
. . . . . . . . 188T,
. . . . . . . . 200T,
. . . . . . . . syn338G (GGc),
. . . . . . . . HA Truncated after aa348)

. . . . JapanKitakyusyu8_2011_01_18 (
. . . . . . . . GISAID HA EPI320267
. . . . . . . . 8 Polymorphisms (5 Amino and 3 Silent)
. . . . . . . . syn34N (AAt),
. . . . . . . . 158E mix wt,
. . . . . . . . 188T,
. . . . . . . . 200T,
. . . . . . . . 214N mix wt,
. . . . . . . . syn296Q (CAa),
. . . . . . . . 301V,
. . . . . . . . syn338G (GGc),
. . . . . . . . HA Truncated after aa348)

. . . . JapanShizuoka19_2011_01_18 (
. . . . . . . . GISAID HA EPI320236
. . . . . . . . 7 Polymorphisms (3 Amino and 4 Silent)
. . . . . . . . syn10Y (TAc),
. . . . . . . . syn34N (AAt),
. . . . . . . . 146G,
. . . . . . . . 188T,
. . . . . . . . 200T mix wt,
. . . . . . . . syn338G (GGc),
. . . . . . . . syn342G (GGa),
. . . . . . . . HA Truncated after aa348)

. . . . JapanEhime4_2011_01_18 (
. . . . . . . . GISAID HA EPI320249
. . . . . . . . 10 Polymorphisms (6 Amino and 4 Silent)
. . . . . . . . syn10Y (TAc),
. . . . . . . . syn34N (AAt),
. . . . . . . . 122N mix wt,
. . . . . . . . syn125S (TCc),
. . . . . . . . 146G,
. . . . . . . . 163R,
. . . . . . . . 188T,
. . . . . . . . 200T,
. . . . . . . . 205E mix wt,
. . . . . . . . syn338G (GGc),
. . . . . . . . HA Truncated after aa348)

. . . . JapanEhime4_2011_01_18 (
. . . . . . . . GISAID NA EPI320248
. . . . . . . . 7 Polymorphisms (3 Amino and 4 Silent)
. . . . . . . . 44S,
. . . . . . . . syn240T (ACc),
. . . . . . . . 241I,
. . . . . . . . syn304V (GTa),
. . . . . . . . 369K,
. . . . . . . . syn377P (CCa),
. . . . . . . . syn460G (GGc))

. . . . JapanShimane37_2011_01_17 (
. . . . . . . . GISAID HA EPI320253
. . . . . . . . 12 Polymorphisms (6 Amino and 6 Silent)
. . . . . . . . syn10Y (TAc),
. . . . . . . . syn34N (AAt),
. . . . . . . . syn125S (TCc),
. . . . . . . . 146G,
. . . . . . . . 156E,
. . . . . . . . 163R,
. . . . . . . . 165I,
. . . . . . . . 188T,
. . . . . . . . 200T,
. . . . . . . . syn214K (AAa),
. . . . . . . . syn283Q (CAa),
. . . . . . . . syn338G (GGc),
. . . . . . . . HA Truncated after aa348)

. . . . JapanShimane37_2011_01_17 (
. . . . . . . . GISAID NA EPI320252
. . . . . . . . 7 Polymorphisms (3 Amino and 4 Silent)
. . . . . . . . 44S,
. . . . . . . . syn240T (ACc),
. . . . . . . . 241I,
. . . . . . . . syn304V (GTa),
. . . . . . . . 369K,
. . . . . . . . syn377P (CCa),
. . . . . . . . syn460G (GGc))

. . . . JapanSagamihara5_2011_01_17 (
. . . . . . . . GISAID HA EPI320239
. . . . . . . . 6 Polymorphisms (3 Amino and 3 Silent)
. . . . . . . . syn10Y (TAc),
. . . . . . . . syn34N (AAt),
. . . . . . . . 146G,
. . . . . . . . 188T,
. . . . . . . . 200T,
. . . . . . . . syn338G (GGc),
. . . . . . . . HA Truncated after aa348)

. . . . JapanSagamihara5_2011_01_17 (
. . . . . . . . GISAID NA EPI320238
. . . . . . . . 6 Polymorphisms (3 Amino and 3 Silent)
. . . . . . . . 44S,
. . . . . . . . syn240T (ACc),
. . . . . . . . 241I,
. . . . . . . . syn304V (GTa),
. . . . . . . . 369K,
. . . . . . . . syn377P (CCa))

. . . . JapanKumamotoC7_2011_01_17 (
. . . . . . . . GISAID HA EPI320234
. . . . . . . . 7 Polymorphisms (4 Amino and 3 Silent)
. . . . . . . . syn10Y (TAc),
. . . . . . . . syn34N (AAt),
. . . . . . . . 122N,
. . . . . . . . 146G,
. . . . . . . . 188T,
. . . . . . . . 200T,
. . . . . . . . syn338G (GGc),
. . . . . . . . HA Truncated after aa348)

. . . . JapanKumamotoC7_2011_01_17 (
. . . . . . . . GISAID NA EPI320233
. . . . . . . . 6 Polymorphisms (3 Amino and 3 Silent)
. . . . . . . . 44S,
. . . . . . . . syn240T (ACc),
. . . . . . . . 241I,
. . . . . . . . syn304V (GTa),
. . . . . . . . 369K,
. . . . . . . . syn377P (CCa))

. . . . JapanShimane24_2011_01_14 (
. . . . . . . . GISAID HA EPI320261
. . . . . . . . 8 Polymorphisms (4 Amino and 4 Silent)
. . . . . . . . #3I,
. . . . . . . . syn34N (AAt),
. . . . . . . . syn42G (GGa),
. . . . . . . . 188T,
. . . . . . . . 200T,
. . . . . . . . syn296Q (CAa),
. . . . . . . . 297D,
. . . . . . . . syn338G (GGc),
. . . . . . . . HA Truncated after aa348)

. . . . JapanShimane24_2011_01_14 (
. . . . . . . . GISAID NA EPI320260
. . . . . . . . 6 Polymorphisms (4 Amino and 2 Silent)
. . . . . . . . 44S,
. . . . . . . . syn240T (ACc),
. . . . . . . . 241I,
. . . . . . . . 369K,
. . . . . . . . syn377P (CCa),
. . . . . . . . 415M)

. . . . JapanKobe463_2011_01_12 (
. . . . . . . . GISAID HA EPI320257
. . . . . . . . 5 Polymorphisms (2 Amino and 3 Silent)
. . . . . . . . syn34N (AAt),
. . . . . . . . 188T,
. . . . . . . . 200T,
. . . . . . . . syn296Q (CAa),
. . . . . . . . syn338G (GGc),
. . . . . . . . HA Truncated after aa348)

. . . . JapanKobe463_2011_01_12 (
. . . . . . . . GISAID NA EPI320256
. . . . . . . . 11 Polymorphisms (7 Amino and 4 Silent)
. . . . . . . . syn28N (AAt),
. . . . . . . . 44S,
. . . . . . . . 70N,
. . . . . . . . 200S mix wt,
. . . . . . . . syn240T (ACc),
. . . . . . . . 241I,
. . . . . . . . syn291V (GTa),
. . . . . . . . 322L,
. . . . . . . . 369K,
. . . . . . . . syn377P (CCa),
. . . . . . . . 415M)

. . . . JapanWakayama8_2011_01_11 (
. . . . . . . . GISAID HA EPI320251
. . . . . . . . 4 Polymorphisms (2 Amino and 2 Silent)
. . . . . . . . 100N,
. . . . . . . . syn179L (CTg),
. . . . . . . . 188T,
. . . . . . . . syn338G (GGc),
. . . . . . . . HA Truncated after aa348)

. . . . JapanWakayama8_2011_01_11 (
. . . . . . . . GISAID NA EPI320250
. . . . . . . . 6 Polymorphisms (2 Amino and 4 Silent)
. . . . . . . . syn162P (CCc),
. . . . . . . . syn240T (ACc),
. . . . . . . . 241I,
. . . . . . . . 369K,
. . . . . . . . syn377P (CCa),
. . . . . . . . syn416D (GAc))

. . . . JapanIshikawa22183_2011_01_10 (
. . . . . . . . GISAID HA EPI320232
. . . . . . . . 7 Polymorphisms (3 Amino and 4 Silent)
. . . . . . . . syn34N (AAt),
. . . . . . . . syn42G (GGa),
. . . . . . . . 188T,
. . . . . . . . 200T,
. . . . . . . . 212E mix wt,
. . . . . . . . syn296Q (CAa),
. . . . . . . . syn338G (GGc),
. . . . . . . . HA Truncated after aa348)

. . . . JapanIshikawa22183_2011_01_10 (
. . . . . . . . GISAID NA EPI320231
. . . . . . . . 8 Polymorphisms (6 Amino and 2 Silent)
. . . . . . . . 44S,
. . . . . . . . 49S mix wt,
. . . . . . . . 215I mix wt,
. . . . . . . . syn240T (ACc),
. . . . . . . . 241I,
. . . . . . . . 369K,
. . . . . . . . syn377P (CCa),
. . . . . . . . 415M)

. . . . JapanSakai2_2011_01_04 (
. . . . . . . . GISAID HA EPI320262
. . . . . . . . 6 Polymorphisms (3 Amino and 3 Silent)
. . . . . . . . syn10Y (TAc),
. . . . . . . . syn34N (AAt),
. . . . . . . . 146G,
. . . . . . . . 188T,
. . . . . . . . 200T,
. . . . . . . . syn338G (GGc),
. . . . . . . . HA Truncated after aa348)

. . . . JapanMiyazaki55_2010_12_17 (
. . . . . . . . GISAID HA EPI320272
. . . . . . . . 9 Polymorphisms (3 Amino and 6 Silent)
. . . . . . . . syn10Y (TAc),
. . . . . . . . syn34N (AAt),
. . . . . . . . syn98F (TTt),
. . . . . . . . syn122K (AAa),
. . . . . . . . 146G,
. . . . . . . . 188T,
. . . . . . . . 200T,
. . . . . . . . syn332L (CTg),
. . . . . . . . syn338G (GGc),
. . . . . . . . HA Truncated after aa348)

Clade 3:
186P

. . . . JapanHiroshimaC28_2011_01_19 (
. . . . . . . . GISAID HA EPI320243
. . . . . . . . 9 Polymorphisms (4 Amino and 5 Silent)
. . . . . . . . syn#12K (AAa),
. . . . . . . . 137T,
. . . . . . . . 144S,
. . . . . . . . syn163K (AAa),
. . . . . . . . 186P,
. . . . . . . . syn251L (CTg),
. . . . . . . . syn287G (GGg),
. . . . . . . . syn293L (CTt),
. . . . . . . . 298V,
. . . . . . . . HA Truncated after aa348)

. . . . JapanHiroshimaC28_2011_01_19 (
. . . . . . . . GISAID NA EPI320242
. . . . . . . . 8 Polymorphisms (5 Amino and 3 Silent)
. . . . . . . . 29M,
. . . . . . . . 46T,
. . . . . . . . syn126P (CCt),
. . . . . . . . syn187G (GGt),
. . . . . . . . 313R,
. . . . . . . . 394I,
. . . . . . . . syn430R (CGg),
. . . . . . . . 467V)

. . . . JapanYamagata54_2011_01_17 (
. . . . . . . . GISAID HA EPI320263
. . . . . . . . 9 Polymorphisms (4 Amino and 5 Silent)
. . . . . . . . syn92T (ACa) mix wt,
. . . . . . . . 137T,
. . . . . . . . 144S,
. . . . . . . . syn163K (AAa),
. . . . . . . . 186P,
. . . . . . . . syn251L (CTg),
. . . . . . . . syn287G (GGg),
. . . . . . . . syn293L (CTt),
. . . . . . . . 298V,
. . . . . . . . HA Truncated after aa348)

Clade 4:
128D

. . . . JapanWakayamaC49_2010_12_07 (
. . . . . . . . GISAID HA EPI320280
. . . . . . . . 5 Polymorphisms (2 Amino and 3 Silent)
. . . . . . . . syn44L (tTA),
. . . . . . . . syn106E (GAa),
. . . . . . . . 128D,
. . . . . . . . 259T,
. . . . . . . . syn272D (GAc),
. . . . . . . . HA Truncated after aa348)

. . . . JapanWakayamaC49_2010_12_07 (
. . . . . . . . GISAID NA EPI320279
. . . . . . . . 7 Polymorphisms (3 Amino and 4 Silent)
. . . . . . . . 15I,
. . . . . . . . 83A,
. . . . . . . . 189S,
. . . . . . . . syn238C (TGt),
. . . . . . . . syn264V (GTt),
. . . . . . . . syn275H (CAt),
. . . . . . . . syn451D (GAt))

. . . . JapanWakayamaC48_2010_12_07 (
. . . . . . . . GISAID HA EPI320278
. . . . . . . . 6 Polymorphisms (2 Amino and 4 Silent)
. . . . . . . . syn44L (tTA),
. . . . . . . . syn106E (GAa),
. . . . . . . . 128D,
. . . . . . . . syn178V (GTa),
. . . . . . . . 259T,
. . . . . . . . syn272D (GAc),
. . . . . . . . HA Truncated after aa348)

. . . . JapanWakayamaC48_2010_12_07 (
. . . . . . . . GISAID NA EPI320277
. . . . . . . . 7 Polymorphisms (3 Amino and 4 Silent)
. . . . . . . . 15I,
. . . . . . . . 83A,
. . . . . . . . 189S,
. . . . . . . . syn238C (TGt),
. . . . . . . . syn264V (GTt),
. . . . . . . . syn275H (CAt),
. . . . . . . . syn451D (GAt))

. . . . JapanWakayamaC47_2010_12_05 (
. . . . . . . . GISAID HA EPI320276
. . . . . . . . 5 Polymorphisms (2 Amino and 3 Silent)
. . . . . . . . syn44L (tTA),
. . . . . . . . syn106E (GAa),
. . . . . . . . 128D,
. . . . . . . . 259T,
. . . . . . . . syn272D (GAc),
. . . . . . . . HA Truncated after aa348)

. . . . JapanWakayamaC47_2010_12_05 (
. . . . . . . . GISAID NA EPI320275
. . . . . . . . 7 Polymorphisms (3 Amino and 4 Silent)
. . . . . . . . 15I,
. . . . . . . . 83A,
. . . . . . . . 189S,
. . . . . . . . syn238C (TGt),
. . . . . . . . syn264V (GTt),
. . . . . . . . syn275H (CAt),
. . . . . . . . syn451D (GAt))

. . . . JapanOsaka_C25_2010_12_03 (
. . . . . . . . GISAID HA EPI320271
. . . . . . . . 3 Polymorphisms (1 Amino and 2 Silent)
. . . . . . . . syn#5L (CTg),
. . . . . . . . syn60I (ATc),
. . . . . . . . 128D,
. . . . . . . . HA Truncated after aa348)

. . . . JapanOsaka_C25_2010_12_03 (
. . . . . . . . GISAID NA EPI320270
. . . . . . . . 5 Polymorphisms (4 Amino and 1 Silent)
. . . . . . . . 264I,
. . . . . . . . syn339S (TCa),
. . . . . . . . 359V,
. . . . . . . . 397K,
. . . . . . . . 442I)

Clade 5:
208K, 219V

. . . . JapanKobe536_2011_02_02 (
. . . . . . . . GISAID HA EPI320259
. . . . . . . . 10 Polymorphisms (5 Amino and 5 Silent)
. . . . . . . . syn47L (CTg),
. . . . . . . . syn82I (ATc),
. . . . . . . . syn93C (TGc),
. . . . . . . . 100N,
. . . . . . . . 141Q,
. . . . . . . . syn170N (AAc),
. . . . . . . . 208K,
. . . . . . . . 219V,
. . . . . . . . 252L,
. . . . . . . . syn307P (CCc),
. . . . . . . . HA Truncated after aa348)

. . . . JapanKobe536_2011_02_02 (
. . . . . . . . GISAID NA EPI320258
. . . . . . . . 6 Polymorphisms (1 Amino and 5 Silent)
. . . . . . . . syn89S (TCt),
. . . . . . . . syn126P (CCt),
. . . . . . . . syn229S (TCc),
. . . . . . . . syn236G (GGc),
. . . . . . . . syn241V (GTg),
. . . . . . . . 299A)

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