Ukraine and Spain Cross-Linked HA and NA Silent Changes Circle the Globe

Cross-Linked HA and NA Polymorphisms Correlated with Fatal 225G Cases in the Ukraine and Russia
  • HA:syn413K encoded from A1281G, AAa->AAg
  • NA:syn407V encoded from T1221C, GTt->GTc
 PF11 Sequences Demonstrating Cross Segment Linkage
  • Ukraine LvivN2
  • Ukraine LvivN6
  • Ukraine TernopilN10
  • Ukraine TernopilN11
  • HA and NA Norway2924 with mixture of 225D and 225G *
  • HA and NA Norway3364-2
  • HA and NA CatNS7362 TamiFlu Resistant
  • HA and NA CatS1096
  • HA and NA CatS1162
  • HA and NA CatS1179
  • HA and NA CatS1181
  • HA and NA CatS1267
  • HA and NA CatS1268
  • HA and NA CatS1402
  • HA and NA CatS1501
  • HA and NA CatS1687
  • HA and NA CatS1748
  • HA and NA CatS1751
  • HA and NA CatS1761
  • HA and NA CatS1827
  • HA and NA Guangdong02
  • HA and NA Guangdong05
  • HA and NA SingaporeON1156
  • HA and NA Stockholm31
  • HA and NA Russia14 *
  • HA and NA Russia19 *
  • HA and NA Russia74 *
  • HA and NA Russia165 *
  • HA and NA Russia178 *
  • HA and NA Russia190 *
  • HA and NA Russia191 *
  • HA and NA Omsk02 
  • HA and NA Salekhard01 with 225G, presumptive Fatal outcome *
  • HA and NA NY3702
  • HA and NA NY3715
  • HA and NA NY3828
  • HA and NA RhodeIsland08
  • HA and NA Texas42102708 *
  • HA and NA Texas45072128 *
  • HA and NA Texas45122886 *
  • US Private Sequence TamiFlu Resistant  
41 sequences have encircled the globe as of 2009-12-31 * with high fidelity carrying a cross-segment paired set of background markers matching and potentially contributing to the Ukraine fatal cases.  Two now additionally demonstrate the TamiFlu Resistant 275Y on NA, one from Spain in late November 2009 and one from the US with details stored in a private database. 

Areas covered include Texas (3), the Northeastern United States (4), China (2), Singapore, the Ukraine (4), Russia (9), Norway (2), Sweden and extensive penetration in Spain (one-third of the dual matches, 14 sequences).  This particular background pattern may precurse 225G and mixtures of 225D / 225G.  If LvivN6 is officially confirmed as a vaccine escape event, these cross-segment pairs may be surveilled as potential future effectors of vaccine efficacy failure.

Publication of the remaining Neuraminidase segments for the 33 Norwegian and Japanese specimens bearing HA syn413K would allow a more precise review.  Although 9 of the recent sequences from Norway carry syn413K, none of the 225E strains from Norway have the syn413K.  The patterns are highly suggestive that all of the Norse 225G strains do.  The 2009-12-29 release of the NA for Norway2924 confirmed that previous suggestion.

Every Biological Organism Starts Somewhere 

Though the exact origin is not always single point, nor always precisely definable as to geography and timing, the term, "emergence", is generally employed because scientific enquiry requires determination of those "starts", of the ultimate origin.  The viral reservoirs are simpler to track than most complex organisms, so we do.  A wise sage from China once said that a journey of a thousand miles begins with a single step.  Likewise, the emergence of a new pandemic strain begins with a single strain.  We remind the reader that  ΣPF11 swept the globe in less than 6 weeks.

Even one change in one sample during this stage of zoonotic flux where we stand today in ΣPF11 holds the potential to increase in range and penetration.  That potential should guide a portion of our studies toward the outliers, such as the emerging sub-clades or even the single, novel strain with key changes.  A paired set of cross-segment polymorphisms patterned into a sub-clade including fatal 225G cases and shared across 41 sequences encircling the globe considerably increases the importance of this proposed framework that validates emergence of "minor" sub-clades.

Dogma rarely delivers.  Science may only measure what science will see.  Eyes closed to an uncomfortable pattern or a face turned away from a malanthropic misfit does not dematerialise that misfit or render that pattern any less real.  Though ignoring the outlier is sometimes necessary to gain an average understanding (like a phylogenetic tree), monitoring those outliers for functional differentiation may predict a future state.  Science and ignorance should be mutually exclusive

Measure the data.  Balance the facts.  Build the logic framework around those facts, even when they no longer agree with your present foundation.

Mankind is depending on you.

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