Spain deposited 239 sequences today at GenBank.
A/Catalonia/NS1706, sampled on 2009-07-29,
Segment 4 (HA) and
Segment 6 (NA)
A/Catalonia/NS2001, sampled on 2009-08-03,
Segment 4 (HA) and
Segment 6 (NA)
A/Catalonia/NS2008, sampled on 2009-08-03,
Segment 4 (HA) and
Segment 6 (NA)
225G is found on these 3 Spanish Hemagglutinins as in the
2 Sao Paulo cases during the same late July to early August timeframe. On the
CatNS1706 specimen, 206S is paired with the
225G; whereas, the Brasilian deaths were 206T and
225G similar to
CatNS2001 and
CatNS2008. During the same timeframe, two cities more than 5,000 miles distant with an ocean between them each have
emergence of multiple novel sub-clades for their geography related to the Receptor Binding Domain residue 225. Consider seasonality and your puzzlement is enhanced.
225G is consensus for H5N1, is carried on NewYork1918 and only appears in 8 other PF11 sequences across the US and Mexico.
SaoPaulo53206
SaoPaulo53225
MX3955
MXInDRE4114
NY04
GA01
TX05
TX11
225X is demonstrated several times in the US proximal to 225G in area and time.
NY11
NY31
TX10
CA13
NE02
CatNS2001 and
CatNS2008 also feature HA
298V, a potential reversion to swine sequences or to 2008 Seasonal. Because 206T is featured in these two sequences and 206T is exclusive of 296H, we may perhaps postulate a
secondary acquisition pathway for an
unidentified human-fit, trait-enhancing domain (HA296:301).
Three additional sequences in this deposit carry the pair of
206T and 298V:
All 5 of these Catalonia
298V specimens carry a 225 polymorphism, either
225E or
225G.
An
Intra-Segment Exclusivity exists within the Catalonia specimens between 206S and 225E. 24 of 25 Catalonia 225E specimens carry
206T, all but the unusual CatS1161 with
206A.
Neuraminidase Quadruple Combination
- CatNS1706 = 106V, 248N, 275H, 286G
- CatNS2001 = 106I, 248D, 275H, 286S
- CatNS2008 = 106I, 248D, 275H, 286S
- CatNS1237 = 106I, 248D, 275H, 286S
- CatNS1248 = 106I, 248D, 275H, 286S
- CatNS1286 = 106I, 248D, 275H, 286S
NA 286G appears on 30 GenBank specimens within
ΣPF11, 24 of them from Catalonia.
Non-Random Acquisition Acceleration appears to be underway in potential trait-enhancing domains of both Antigen segments.
Influenza Flux is a two way street with
clearly defined lanes and
many points of ingress.
The
Hydra Effect is demonstrated in the phylogenic trees of Brasil and Spain. When your tree is
all branches with
only a few leaves at each tip, you aren’t going to get much protection from the sun unless you decided very early to be standing on just the right spot when the perfect light of noon arrives.
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