Though these sequences all share a starting polymorphism, each develops one or more additional novel antigenic revisions. The build pattern is suggestive that surveillance efforts are lacking. The database contains no intermediate forms that would allow us to observe the individual genetic acquisitions from the birds, pigs and humans as they occurred to build this minimum two step magnetism from H5N1 and H5N2 onto the Iran H1N1 background.
NA Amino Acid Codings to 5 Novel Polymorphisms and 1 Singular Signal
- 4K
- 74L
- 81G
- 346V (synonymous A1038G)
- 452S
- 454S
4K
Novel to ΣPF11.
100% of the Iranian sequences carry Lysine at the fourth amino acid position (4K), a novel finding in the pandemic reservoir that appears to be only recorded in two earlier sequences.
Progenitors may include:
A/duck/Eastern China/06/2000 (H5N2)
A/Fort Warren/1/1950 (H1N1)
74L
Bogota0466N is the singular ΣPF11 instance.
Lorestan1599
Progenitors may include:
red-winged tinamou/Argentina/MP1/2008 H1N1
with HA 225G, 277N, 286H, 298V / NA 106I, 248N, 286G
81G
Novel to ΣPF11.
Lorestan1599
Progenitor unknown.
syn346V
Novel to ΣPF11.
Ghom1550
Progenitors may include:
A/Thailand/271/2005 (H1N1) with NA 45K & HA 225G, 261N, 263D, 264P and 270T, also manages to carry the silent NA:A1038G coding for a synonymous Valine at residue 346 on the Neuramindase (346V) of Ghom1550. This silent change is found across many serotypes and primarily spans Avian and Swine species. Influenza Flux may be at work.
452S
Novel to ΣPF11.
Khorasan1583
Progenitor unknown.
454S
Novel to ΣPF11.
Khorasan1583
Progenitors may include:
H5N1 2009 Human Toddler passage Egypt
H5N1 2009 Avian Worldwide
H1N1 2005 Human Iowa swine worker (IA/CEID23/2005)
H1N1 NC swine 36883, HK swine NS1659
Neuraminidase Quadruple Combination
106I, 248D, 275H, 286S
