Though considerable divergency is currently being demonstrated within the recent UK severe wave, two different sets of combinations have been coalescing throughout the world since late 2009 and have begun forming sub-clades in the past 4 months that are demonstrated well in these 3 Iranian sequences.
Do these Iranian sequences signal the type of zoonotic genetic behaviour that is driving some areas of the UK today to report an 800% rise in the number ill from Pandemic H1N1?
Though the origins of the primary branching polymorphisms begin much earlier, the later stages of transmission during late Summer and early Fall 2010 (Northern Hemisphere designations) more clearly distinguish the coalescence. Florida13 and Florida14 during August 2010 are recorded as having progenitor co-circulation of these two divergent sub-clades that transmitted and continued into the UK and Iran. Florida13_2010_08_02 has 4 of the same SNPs as IranBandarAbbas5096_2010_10_02. 100% of those matches [4 of 4 (137T, 186P, 377G, syn474C)] between Florida and Iran are also found in animal reservoirs.
Recall that small incursions of genetics from animal reservoirs are known to imbalance viral behaviour in the new human host. The HA 377G found on Florida13 and BandarAbbas5096 exists on the fatal UKEngland4500186_2010_11_f sequence and four other UK sequences from October and November of 2010, but was not notated on the HPA Ellis Figure3 1 phylogenetic tree.
- UKEngland83_2010_10
- UKEngland87_2010_10
- UKEngland5500192_2010_10
- UKEngland119_2010_11
- UKEngland4500186_2010_11_f
- UK_2010_Phylo_ELLIS_Fig3new_4_GISAID_Notated_2011_01_13.JPG
- GeneWurx_UK_December_Emerging_Genetics_v5.xls
The IranShahriar5336_2010_12_06 evaluation details a remarkable hyper-zoonosis. At least 78% of the polymorphisms (7 of 9) are clearly demonstrated as amino acid variation or single nucleotide polymorphisms in animal reservoirs, primarily H3N8, H5N1 and H7N7. Wisconsin08_2010_08_10 shares homology at 7 of the IranShahriar5336_2010_12_06 SNPs. 86% of those matches [6 of 7 (137T, 186P, syn297N, 388K, 444K, syn474C)] between Wisconsin and Iran are found in animals (5 in H3N8).
The homology between Iran and the UK is more striking than either of these vivid US examples and may be well visualised by scrolling through the GeneWurx v5 spreadsheet detailing these specific changes with combinational development over the course of this pandemic.
. . . . IranShahriar5336_2010_12_06 (
. . . . . . . . 137T (aCA) [H3N8 donor aAT, aGT, aGC],
. . . . . . . . 186P [Avian H12 2008, 2009], [Avian H1N1],
. . . . . . . . syn297N [H3N8 gadwallRussiaAltai1325_2007_09],
. . . . . . . . . . . . . . . [H5N1],
. . . . . . . . . . . . . . . [Wisconsin08_2010_08_10
. . . . . . . . . . . . . . . . . . . . . . with 39R, syn78S, 137T, 186P, syn297N,
. . . . . . . . . . . . . . . . . . . . . . . . . . syn326S, syn346G, syn388K,
. . . . . . . . . . . . . . . . . . . . . . . . . . syn413K, 444K, syn474C,
. . . . . . . . . . . . . . . CalifVRDL2_2010_01_11
. . . . . . . . . . . . . . . . . . . . . . with syn121P & 502K,
. . . . . . . . . . . . . . . YaroslavlIIV196_2009_12_04_f
. . . . . . . . . . . . . . . . . . . . . . with syn159N, 225G,
. . . . . . . . . . . . . . . WiscD0128_2009_11_15
. . . . . . . . . . . . . . . . . . . . . . with syn343G, 377G, 471H,
. . . . . . . . . . . . . . . Brussels243_2009_11_09
. . . . . . . . . . . . . . . . . . . . . . with syn44L, syn159N & syn323N,
. . . . . . . . . . . . . . . Australia6_2009_07_18
. . . . . . . . . . . . . . . . . . . . . . with syn159N, 233H]
. . . . . . . . syn326S [Wisconsin08_2010_08_10
. . . . . . . . . . . . . . . . . . . . . . with 39R, syn78S, 137T, 186P, syn297N,
. . . . . . . . . . . . . . . . . . . . . . . . . . syn326S, syn346G, syn388K,
. . . . . . . . . . . . . . . . . . . . . . . . . . syn413K, 444K, syn474C,
. . . . . . . . . . . . . . . Zhongyuan1643_2009_11_16
. . . . . . . . . . . . . . . . . . . . . . with 208G],
. . . . . . . . syn383N [H3N8],
. . . . . . . . syn388K [H3N8, H5N1, S7],
. . . . . . . . . . . . . . . [OzVictoria508_2010_07_24
. . . . . . . . . . . . . . . . . . . . . . . with 238D,
. . . . . . . . . . . . . . . swIowa44837_1_2009_11_08_xL
. . . . . . . . . . . . . . . . . . . . . . . with 188R, 225N & 230I,
. . . . . . . . . . . . . . . Utah20_C2_2_2009_07_25_VxX
. . . . . . . . . . . . . . . . . . . . . . . with 159D & 227G, et al],
. . . . . . . . syn411N (AAc) [H7N3 & H7N7 donor ATc],
. . . . . . . . 444K (AAg) [H3N8 gAg],
. . . . . . . . syn474C [H3N8, Avian H1N1 2010],
. . . . . . . . . . . . . . . [Michigan10_2009_06_03 with 137T, 225N, et al])
. . . . IranBandarAbbas5096_2010_10_02 (
. . . . . . . . 72P,
. . . . . . . . 137T (aCA) [H3N8 donor aAT, aGT, aGC],
. . . . . . . . 186P [Avian H12 2008, 2009], [Avian H1N1],
. . . . . . . . syn318A,
. . . . . . . . 377G [H2N3],
. . . . . . . . . . . . . [H5N1 Human Egypt Preschool 2009, H5N1 Human Indonesia 2005],
. . . . . . . . . . . . . [H6N1 2009],
. . . . . . . . . . . . . [US Swine 1957-1978],
. . . . . . . . . . . . . [Florida13_2010_08_02
. . . . . . . . . . . . . . . . . . . with 137T, 186P, syn474C, 512M,
. . . . . . . . . . . . . . Iowa05_2010_05_04
. . . . . . . . . . . . . . . . . . . with 208K, syn516I,
. . . . . . . . . . . . . . swSouthDakota1_2010_04_27,
. . . . . . . . . . . . . . TexasAF2647_2010_04_11
. . . . . . . . . . . . . . . . . . . with 200S, syn214K, syn276H,
. . . . . . . . . . . . . . swIowa02999_2010_04_01,
. . . . . . . . . . . . . . UtahAF2653_2010_03_14
. . . . . . . . . . . . . . . . . . . with syn253V,
. . . . . . . . . . . . . . North Carolina05_2010_02_24
. . . . . . . . . . . . . . . . . . . with 259V,
. . . . . . . . . . . . . . Kentucky04_2010_02_22
. . . . . . . . . . . . . . . . . . . with syn488D,
. . . . . . . . . . . . . . Minnesota02_2010_02_17
. . . . . . . . . . . . . . . . . . . with 259V, 509D,
. . . . . . . . . . . . . . SouthCarolina01_2010_01_27
. . . . . . . . . . . . . . . . . . . with syn238E, syn488D,
. . . . . . . . . . . . . . AnasPlatBelgium04328_pcs17_2010_01_21
. . . . . . . . . . . . . . . . . . . with syn474C,
. . . . . . . . . . . . . . GermanyAF2208_2010_01_20
. . . . . . . . . . . . . . . . . . . with #1T, 225E,
. . . . . . . . . . . . . . NorthCarolina03_2010_01_20
. . . . . . . . . . . . . . . . . . . with 225G mix, 259V, syn275V,
. . . . . . . . . . . . . . NewMexico01_2010_01_05
. . . . . . . . . . . . . . . . . . . with 430I, syn445V, syn490P,
. . . . . . . . . . . . . . swThailandCU_CHK4_2009_01
. . . . . . . . . . . . . . . . . . with #1T, 0A, 189T, syn338G,
. . . . . . . . . . . . . . . . . . . . . . syn451K, syn474C, syn456L, syn529L,
. . . . . . . . . . . . . . Moldova5053_2009_12_11
. . . . . . . . . . . . . . . . . . with 173R, 176I, 225A, 225G mix wt, syn286K,
. . . . . . . . . . . . . . WiscD0128_2009_11_15
. . . . . . . . . . . . . . . . . . . with syn297N, syn343G, 471H,
. . . . . . . . . . . . . . KoreaAF2411_2009_11_11
. . . . . . . . . . . . . . . . . . . with 237I, syn286K,
. . . . . . . . . . . . . . England94840077_2009_11
. . . . . . . . . . . . . . . . . . . with 259T,
. . . . . . . . . . . . . . BahrainN11892_2009_10
. . . . . . . . . . . . . . . . . . . with 208K,
. . . . . . . . . . . . . . Nevada16_2009_10_02
. . . . . . . . . . . . . . . . . . . with 464R mix wt,
. . . . . . . . . . . . . . Tasmania2005_2009_07_03
. . . . . . . . . . . . . . . . . . . with 289M,
. . . . . . . . . . . . . . Texas42303371_2009
. . . . . . . . . . . . . . . . . . . with syn456L, syn507K],
. . . . . . . . syn449Y (TAc) [H3N8 Ttc],
. . . . . . . . syn474C [H3N8])
. . . . IranKaraj5327_2010_12_06 (
. . . . . . . . syn34N [JapanKanagawa74_2010_10_16, et al],
. . . . . . . . 146G [JapanKanagawa74_2010_10_16, et al],
. . . . . . . . 188T [H7N7],
. . . . . . . . 200T,
. . . . . . . . syn338G,
. . . . . . . . 377K,
. . . . . . . . 454N,
. . . . . . . . syn465N [OzBrisbane209_51F_2010_08_09,
. . . . . . . . . . . . . . . . . . . . with 156E & 225G,
. . . . . . . . . . . . . . CalifVRDL131_2009_12_30, et al],
. . . . . . . . syn538F [Brunei218_2010 with 188T])
A significant correlation exists between syn474C and 137T. 26 of 42 sequences bearing syn474C also carry 137T.
Supporting Sequences
. . . . UKEngland4500186_2010_11_f (
. . . . . . . . 137T (aCA) [H3N8 donor aAT, aGT, aGC],
. . . . . . . . 186P [Avian H12 2008, 2009], [Avian H1N1],
. . . . . . . . 190Y [Avian H6N1],
. . . . . . . . . . [SwedenMalmoe1_2010_01_01_xL
. . . . . . . . . . . . with 377K, syn413K,
. . . . . . . . . . Brasil7450_2009_07_22
. . . . . . . . . . . . with 157E mix wt],
. . . . . . . . 377G [H2N3],
. . . . . . . . . . . . . [H5N1 Human Egypt Preschool 2009, H5N1 Human Indonesia 2005],
. . . . . . . . . . . . . [H6N1 2009],
. . . . . . . . . . . . . [US Swine 1957-1978],
. . . . . . . . . . . . . [IranBandarAbbas5096_2010_10_02
. . . . . . . . . . . . . . . . . . . with 137T, 186P, syn474C,
. . . . . . . . . . . . . Florida13_2010_08_02
. . . . . . . . . . . . . . . . . . . with 137T, 186P, syn474C, 512M,
. . . . . . . . . . . . . . Iowa05_2010_05_04
. . . . . . . . . . . . . . . . . . . with 208K, syn516I,
. . . . . . . . . . . . . . swSouthDakota1_2010_04_27,
. . . . . . . . . . . . . . TexasAF2647_2010_04_11
. . . . . . . . . . . . . . . . . . . with 200S, syn214K, syn276H,
. . . . . . . . . . . . . . swIowa02999_2010_04_01,
. . . . . . . . . . . . . . UtahAF2653_2010_03_14
. . . . . . . . . . . . . . . . . . . with syn253V,
. . . . . . . . . . . . . . North Carolina05_2010_02_24
. . . . . . . . . . . . . . . . . . . with 259V,
. . . . . . . . . . . . . . Kentucky04_2010_02_22
. . . . . . . . . . . . . . . . . . . with syn488D,
. . . . . . . . . . . . . . Minnesota02_2010_02_17
. . . . . . . . . . . . . . . . . . . with 259V, 509D,
. . . . . . . . . . . . . . SouthCarolina01_2010_01_27
. . . . . . . . . . . . . . . . . . . with syn238E, syn488D,
. . . . . . . . . . . . . . AnasPlatBelgium04328_pcs17_2010_01_21
. . . . . . . . . . . . . . . . . . . with syn474C,
. . . . . . . . . . . . . . GermanyAF2208_2010_01_20
. . . . . . . . . . . . . . . . . . . with #1T, 225E,
. . . . . . . . . . . . . . NorthCarolina03_2010_01_20
. . . . . . . . . . . . . . . . . . . with 225G mix, 259V, syn275V,
. . . . . . . . . . . . . . NewMexico01_2010_01_05
. . . . . . . . . . . . . . . . . . . with 430I, syn445V, syn490P,
. . . . . . . . . . . . . . swThailandCU_CHK4_2009_01
. . . . . . . . . . . . . . . . . . with #1T, 0A, 189T, syn338G,
. . . . . . . . . . . . . . . . . . . . . . syn451K, syn474C, syn456L, syn529L,
. . . . . . . . . . . . . . Moldova5053_2009_12_11
. . . . . . . . . . . . . . . . . . with 173R, 176I, 225A, 225G mix wt, syn286K,
. . . . . . . . . . . . . . WiscD0128_2009_11_15
. . . . . . . . . . . . . . . . . . . with syn297N, syn343G, 471H,
. . . . . . . . . . . . . . KoreaAF2411_2009_11_11
. . . . . . . . . . . . . . . . . . . with 237I, syn286K,
. . . . . . . . . . . . . . England94840077_2009_11
. . . . . . . . . . . . . . . . . . . with 259T,
. . . . . . . . . . . . . . BahrainN11892_2009_10
. . . . . . . . . . . . . . . . . . . with 208K,
. . . . . . . . . . . . . . Nevada16_2009_10_02
. . . . . . . . . . . . . . . . . . . with 464R mix wt,
. . . . . . . . . . . . . . Tasmania2005_2009_07_03
. . . . . . . . . . . . . . . . . . . with 289M,
. . . . . . . . . . . . . . Texas42303371_2009
. . . . . . . . . . . . . . . . . . . with syn456L, syn507K],
. . . . . . . . syn408E,
. . . . . . . . syn474C,
. . . . . . . . 512M,
. . . . . . . . 530I)
. . . . UKEngland119_2010_11 (
. . . . . . . . 137T (aCA) [H3N8 donor aAT, aGT, aGC],
. . . . . . . . 186P [Avian H12 2008, 2009], [Avian H1N1],
. . . . . . . . 188N,
. . . . . . . . 377G [H2N3],
. . . . . . . . . . . . . [H5N1 Human Egypt Preschool 2009, H5N1 Human Indonesia 2005],
. . . . . . . . . . . . . [H6N1 2009],
. . . . . . . . . . . . . [US Swine 1957-1978],
. . . . . . . . 391A,
. . . . . . . . syn408E,
. . . . . . . . syn474C,
. . . . . . . . 512M,
. . . . . . . . 530I)
. . . . UKEngland83_2010_10 (
. . . . . . . . 137T (aCA) [H3N8 donor aAT, aGT, aGC],
. . . . . . . . 186P [Avian H12 2008, 2009], [Avian H1N1],
. . . . . . . . syn272D,
. . . . . . . . syn279N,
. . . . . . . . syn352Y,
. . . . . . . . 377G [H2N3],
. . . . . . . . . . . . . [H5N1 Human Egypt Preschool 2009, H5N1 Human Indonesia 2005],
. . . . . . . . . . . . . [H6N1 2009],
. . . . . . . . . . . . . [US Swine 1957-1978],
. . . . . . . . syn408E,
. . . . . . . . syn474C,
. . . . . . . . 509G,
. . . . . . . . 512M,
. . . . . . . . 530I)
. . . . UKEngland87_2010_10 (
. . . . . . . . 137T (aCA) [H3N8 donor aAT, aGT, aGC],
. . . . . . . . 186P [Avian H12 2008, 2009], [Avian H1N1],
. . . . . . . . syn279N,
. . . . . . . . syn352Y,
. . . . . . . . 377G [H2N3],
. . . . . . . . . . . . . [H5N1 Human Egypt Preschool 2009, H5N1 Human Indonesia 2005],
. . . . . . . . . . . . . [H6N1 2009],
. . . . . . . . . . . . . [US Swine 1957-1978],
. . . . . . . . syn408E,
. . . . . . . . syn474C,
. . . . . . . . 509G,
. . . . . . . . 512M,
. . . . . . . . 530I)
. . . . UKEngland5500192_2010_10 (
. . . . . . . . 137T (aCA) [H3N8 donor aAT, aGT, aGC],
. . . . . . . . 186P [Avian H12 2008, 2009], [Avian H1N1],
. . . . . . . . syn279N,
. . . . . . . . syn352Y,
. . . . . . . . 377G [H2N3],
. . . . . . . . . . . . . [H5N1 Human Egypt Preschool 2009, H5N1 Human Indonesia 2005],
. . . . . . . . . . . . . [H6N1 2009],
. . . . . . . . . . . . . [US Swine 1957-1978],
. . . . . . . . syn408E,
. . . . . . . . syn474C,
. . . . . . . . 509G,
. . . . . . . . 512M,
. . . . . . . . 530I)
. . . . Utah20_C2_2_2009_07_25_VxX (
. . . . . . . . #12E,
. . . . . . . . 0I [Latvia12_649_2009_12_09,
. . . . . . . . . NY7426_2009_12_08,
. . . . . . . . . Tambov_FOS_2009_12_01_xL,
. . . . . . . . . Slovenia5555_2009_12,
. . . . . . . . . Slovenia5559_2009_12,
. . . . . . . . . Ivanovo_RNA_2009_11_24_xL_f with 225G, 225N,
. . . . . . . . . Stockholm107_2009_11_24,
. . . . . . . . . GD_Yuncheng51_2009_11_19,
. . . . . . . . . Guangdong1271_2009_11_19,
. . . . . . . . . Austria528378_2009_11_19,
. . . . . . . . . Latvia11_1133_2009_11_16,
. . . . . . . . . Latvia11_1133M_2009_11_16,
. . . . . . . . . Latvia11_575_2009_11_11,
. . . . . . . . . England94600039_2009_10_27,
. . . . . . . . . SwedenUmea8_2009_10_07,
. . . . . . . . . Managua2323_02_2009_08_18,
. . . . . . . . . Texas42163291_2009_06_16,
. . . . . . . . . Marseille3416_2009],
. . . . . . . . 159D,
. . . . . . . . 206S,
. . . . . . . . 227G mix,
. . . . . . . . 296H,
. . . . . . . . syn388K [H5N1],
. . . . . . . . 470I)
. . . . Rome709_2009_07_14 (
. . . . . . . . 35I,
. . . . . . . . syn41N,
. . . . . . . . syn93C,
. . . . . . . . syn96G,
. . . . . . . . 206S,
. . . . . . . . 388M,
. . . . . . . . syn456L,
. . . . . . . . 516X (Ann),
. . . . . . . . 517X (nTG))
. . . . Aarhus241_2009_11_26_xL (
. . . . . . . . 176I, ** connecting Europe to North America xL **
. . . . . . . . syn177L,
. . . . . . . . 206T,
. . . . . . . . 324I,
. . . . . . . . syn383N [India PF11],
. . . . . . . . syn413K [H9N2])
. . . . IndiaPune21115_2009_12 (
. . . . . . . . syn147F [H3N8 Avian, H4, H5, H6, H11],
. . . . . . . . . . . . . . [Yaroslavl_KMP_2009_08_25,
. . . . . . . . . . . . . . IndiaJalna9436_2009_08_30 with 226R,
. . . . . . . . . . . . . . Texas44301765_2009_08_30,
. . . . . . . . . . . . . . CalifVRDL99_2009_11_05,
. . . . . . . . . . . . . . Athens943_2009_06_12],
. . . . . . . . syn163K,
. . . . . . . . 233H,
. . . . . . . . 271T,
. . . . . . . . 289V [Ukraine123_2010_02_14_xL with 230I,
. . . . . . . . . . . . .UK_Glascow_SC10_2009_06 with 225G, et al],
. . . . . . . . 377K [H9N2],
. . . . . . . . syn383N)
. . . . SwedenStockholm5_2010_08_27 (
. . . . . . . . 137T [41 sequences at GISAID],
. . . . . . . . syn163K,
. . . . . . . . 186P,
. . . . . . . . syn363G [21 sequences at GISAID],
. . . . . . . . syn474C,
. . . . . . . . 525G mix [Unique to GISAID; Unique to GenBank])
. . . . OzCanberra8_2010_08_15 (
. . . . . . . . 137T,
. . . . . . . . syn163K,
. . . . . . . . 186P,
. . . . . . . . syn363G,
. . . . . . . . syn397G,
. . . . . . . . syn474C)
. . . . Florida13_2010_08_02 (
. . . . . . . . 51T,
. . . . . . . . 137T,
. . . . . . . . 186P,
. . . . . . . . syn363G,
. . . . . . . . 377G,
. . . . . . . . syn474C,
. . . . . . . . 512M)
. . . . India007_2010_06_17 (
. . . . . . . . 137T,
. . . . . . . . syn163K,
. . . . . . . . 186P,
. . . . . . . . syn363G,
. . . . . . . . syn378I,
. . . . . . . . syn474C)
. . . . India3725_2010_04_03 (
. . . . . . . . 137T,
. . . . . . . . syn167S,
. . . . . . . . 186P,
. . . . . . . . syn474C,
. . . . . . . . syn526S [Malmoe2_2010_05_07 with 89G])
. . . . swItaly85437_2009_12_09 mix (
. . . . . . . . syn40H,
. . . . . . . . 225E,
. . . . . . . . 226R,
. . . . . . . . 300S,
. . . . . . . . syn434N,
. . . . . . . . syn474C,
. . . . . . . . 530I)
. . . . Salekhard01_2009_xL_f (
. . . . . . . . . . . 89N,
. . . . . . . . . . . 158E [H3N8, H5N1],
. . . . . . . . . . . 165N [H9N2],
. . . . . . . . . . . syn168Y [H9N2],
. . . . . . . . . . . 225G,
. . . . . . . . . . . syn413K [H9N2],
. . . . . . . . . . . 444D)
. . . . CubaHabana7374_2010_01 (
. . . . . . . . HA truncated before aa05,
. . . . . . . . 28P,
. . . . . . . . syn32S,
. . . . . . . . 33G,
. . . . . . . . 165N,
. . . . . . . . 232H,
. . . . . . . . 275I,
. . . . . . . . syn287G,
. . . . . . . . syn305K,
. . . . . . . . syn346G,
. . . . . . . . 421M,
. . . . . . . . 432W,
. . . . . . . . 444Y,
. . . . . . . . HA truncated after aa535)
. . . . OzVictoria508_2010_07_24 (
. . . . . . . . 35I [H5N1],
. . . . . . . . 88P [H2N3, H5N1, H11],
. . . . . . . . . . . [HunanHechengSWL1616_2009-11-23,
. . . . . . . . . . . KoreaAF2376_2009_10_27
. . . . . . . . . . . . . . . with 280A and 290K],
. . . . . . . . syn102E [SingON2407_2009_12_13,
. . . . . . . . . . . . . . . Singapore544_2009_12_10,
. . . . . . . . . . . . . . . Brussels243_2009_11_09
. . . . . . . . . . . . . . . . . . . . with syn44L and 89G],
. . . . . . . . syn152I [CalifVRDL115_2009_12_04,
. . . . . . . . . . . . . . . NY6939_2009_12_11,
. . . . . . . . . . . . . . . tkOntarioFAV117_1C_2009_12_07
. . . . . . . . . . . . . . . . . . . . with 35I, syn219I, syn276H, syn456L, 463V, 523A,
. . . . . . . . . . . . . . . England1050_2009_12,
. . . . . . . . . . . . . . . Scotland103_2009_12,
. . . . . . . . . . . . . . . England1051_2009_12,
. . . . . . . . . . . . . . . ItalyAncona451_2009_11_27_f,
. . . . . . . . . . . . . . . NY6607_2009_11_24,
. . . . . . . . . . . . . . . CalifVRDL107_2009_11_15,
. . . . . . . . . . . . . . . CalifVRDL101_2009_11_05,
. . . . . . . . . . . . . . . DC_114_2009_11_04,
. . . . . . . . . . . . . . . England94800096_2009_11,
. . . . . . . . . . . . . . . Calif_SD35_2009_10_26,
. . . . . . . . . . . . . . . NY5447_2009_10_23,
. . . . . . . . . . . . . . . CalifVRDL84_2009_10_09,
. . . . . . . . . . . . . . . CalifVRDL87_2009_10_09,
. . . . . . . . . . . . . . . IndiaPune6196_2009_08,
. . . . . . . . . . . . . . . IndiaDhule9433_2009_08,
. . . . . . . . . . . . . . . SantoDomingoWR1057N_2009_07_02,
. . . . . . . . . . . . . . . SantoDomingoWR1058N_2009_07_02,
. . . . . . . . . . . . . . . SantoDomingoWR1059N_2009_06_30],
. . . . . . . . 206S,
. . . . . . . . syn219I [CalifVRDL115_2009_12_04
. . . . . . . . . . . . . . . . . with 35I, syn152I, syn276H, syn456L, 463V, 523A,
. . . . . . . . . . . . . . FL_Pen213_2009_11_17
. . . . . . . . . . . . . . . . . . . . with 35I, syn152I, 273A, syn456L, 463V, 523A,
. . . . . . . . . . . . . . CalifVRDL107_2009_11_15
. . . . . . . . . . . . . . . . . . . . with 35I, syn152I, syn276H, syn456L, 463V, 523A,
. . . . . . . . 238D (GAc) [H2N3, H7N3, H7N7],
. . . . . . . . . . . . . . . . . . [Belgorod2_2010-03-15 (GAt),
. . . . . . . . . . . . . . . . . . Kaliningrad01_2009_11_02 (GAt)
. . . . . . . . . . . . . . . . . . . . . . . . with 225E and 226R,
. . . . . . . . . . . . . . . . . . AthensINS398_2010-01-24 GAt),
. . . . . . . . . . . . . . . . . . KaliningradCRIE_DA_2009-09-26 (GAt),
. . . . . . . . . . . . . . . . . . KaliningradCRIE_KG_2009-09-25 (GAt),
. . . . . . . . . . . . . . . . . . KaliningradCRIE_MA_2009-09-25 (GAt),
. . . . . . . . . . . . . . . . . . KaliningradCRIE_SHD_2009-09-25 (GAt),
. . . . . . . . . . . . . . . . . . KaliningradCRIE_ZD_2009-09-25 (GAt)],
. . . . . . . . syn247A [Belize8756_2009_10_08,
. . . . . . . . . . . . . . . Singapore93_2009_06_22]
. . . . . . . . syn254P,
. . . . . . . . 272G [Niigata19_2009_12_31,
. . . . . . . . . . . . GuangdongSWL36_2009_11_29],
. . . . . . . . syn276H,
. . . . . . . . syn388K [H5N1],
. . . . . . . . . . . . . . . [NagasakiHA_10_28_2010_03_23
. . . . . . . . . . . . . . . . . . . . . with 22I,
. . . . . . . . . . . . . . . NagasakiHA_10_26_2010_03_15
. . . . . . . . . . . . . . . . . . . . . with 22I, syn103E,
. . . . . . . . . . . . . . . NagasakiHA_10_24_2010_03_08
. . . . . . . . . . . . . . . . . . . . . with syn103E,
. . . . . . . . . . . . . . . GuangxiLonganSWL1990_2010_02_08
. . . . . . . . . . . . . . . . . . . . . with 453K, syn462E,
. . . . . . . . . . . . . . . JiangxiDonghuSWL15_2010_01_04
. . . . . . . . . . . . . . . . . . . . . with syn106E, 149R, syn456L (TTg),
. . . . . . . . . . . . . . . ViennaINS142_2009_11_26
. . . . . . . . . . . . . . . . . . . . . with syn97D, 99T,
. . . . . . . . . . . . . . . CzechUsti208_2009_11_25
. . . . . . . . . . . . . . . . . . . . . with 268T,
. . . . . . . . . . . . . . . GhanaFS_1921_2009_11_11,
. . . . . . . . . . . . . . . Alaska44_2009_11_17
. . . . . . . . . . . . . . . . . . . . . with syn275V, 276N,
. . . . . . . . . . . . . . . CalifVRDL76_2009_09_21
. . . . . . . . . . . . . . . . . . . . . with syn283Q,
. . . . . . . . . . . . . . . Taiwan206_2009_09_18,
. . . . . . . . . . . . . . . Taiwan177_2009_09_18,
. . . . . . . . . . . . . . . Taiwan167_2009_09_18,
. . . . . . . . . . . . . . . Taiwan156_2009_09_18,
. . . . . . . . . . . . . . . Taiwan143_2009_09_15
. . . . . . . . . . . . . . . . . . . . . with 205E mix,
. . . . . . . . . . . . . . . Utah20_C2_2_2009_07_25_VxX
. . . . . . . . . . . . . . . . . . . . . with 159D, 206S, 227G
. . . . . . . . . . . . . . . Slovenia2687_2009_07_01
. . . . . . . . . . . . . . . . . . . . . with 35I, 206S],
. . . . . . . . syn456L,
. . . . . . . . 463V,
. . . . . . . . 523A [Nebraska02_2010_03_11,
. . . . . . . . . . . . NagasakiHA1022_2010_03_01_syn413K,
. . . . . . . . . . . . DomRepublic3768_2009_12_15,
. . . . . . . . . . . . NY6939_2009_12_11,
. . . . . . . . . . . . CalifVRDL115_2009_12_04,
. . . . . . . . . . . . NY6607_2009_11_24,
. . . . . . . . . . . . RheinlandPfalz81_2009_11_23,
. . . . . . . . . . . . Berlin210_2009_11_16,
. . . . . . . . . . . . BadenWurttemberg511_2009_11_16,
. . . . . . . . . . . . CalifVRDL107_2009_11_15,
. . . . . . . . . . . . FL_Pensacola40_2009_11_09,
. . . . . . . . . . . . CalifVRDL101_2009_11_05,
. . . . . . . . . . . . DC114_2009_11_04,
. . . . . . . . . . . . Calif_SD35_2009_10_26,
. . . . . . . . . . . . NY5447_2009_10_23,
. . . . . . . . . . . . CalifVRDL84_2009_10_09,
. . . . . . . . . . . . CalifVRDL87_2009_10_09,
. . . . . . . . . . . . KuwaitN13013_2009_08_31_syn413K])
. . . . Zhongyuan1643_2009_11_16 (131P, 208G, syn326S)
. . . . YaroslavlIIV196_2009_12_04_f (
. . . . . . . . . . . syn7C,
. . . . . . . . . . . 89G [H7N7],
. . . . . . . . . . . syn159N [H3N8, H9N2],
. . . . . . . . . . . 225G,
. . . . . . . . . . . syn297N [H5N1],
. . . . . . . . . . . syn319T [H5N1],
. . . . . . . . . . . syn428L [H5N1])
. . . . Australia6_2009_07_18 (
. . . . . . . . 89G [H7N7],
. . . . . . . . syn159N [H3N8, H9N2],
. . . . . . . . 233H,
. . . . . . . . syn297N [H5N1],
. . . . . . . . syn406R [1918, WSN33, S9, S7, M7])
. . . . CalifVRDL2_2010_01_11 (
. . . . . . . . syn121P,
. . . . . . . . syn193S [H3N8, H6N1],
. . . . . . . . 206T,
. . . . . . . . syn297N,
. . . . . . . . 377K [H9N2],
. . . . . . . . 502K [UkrTernopilN10_2009_10_28_xL_f with 225G,
. . . . . . . . . . . Oz_Victoria800_2010_06_02,
. . . . . . . . . . . SingGP2362_2010_05_18,
. . . . . . . . . . . Scandinavia (7),
. . . . . . . . . . . California33_2009_08_06,
. . . . . . . . . . . Michigan21_2009_08_07,
. . . . . . . . . . . SouthCarolina36_2009_09_02,
. . . . . . . . . . . SouthCarolina38_2009_09_17,
. . . . . . . . . . . Haiti534_2009_10_19,
. . . . . . . . . . . AlgeriaG2902_2009_12_09 mix with 225E,
. . . . . . . . . . . Egypt114_2009_12_06 with 225E,
. . . . . . . . . . . JapanPR1070_2009_07_10,
. . . . . . . . . . . ThailandTHB0438_2009_07_28,
. . . . . . . . . . . Jiangyin34_2009_08_16,
. . . . . . . . . . . GuangxiLongan1870_2009_12_16])
. . . . Brussels243_2009_11_09 (
. . . . . . . . #10T [KyrgyzstanBishkekWR0881T_2009_12_02,
. . . . . . . . . . . . IndiaPune9355_2009_08 with 225G,
. . . . . . . . . . . . IndiaPune8489_2009_08 with 237I,
. . . . . . . . . . . . IndiaPune6447_2009_08],
. . . . . . . . syn44L,
. . . . . . . . 89G [H7N7],
. . . . . . . . syn102E,
. . . . . . . . syn159N [H3N8, H9N2],
. . . . . . . . 202A,
. . . . . . . . 252L,
. . . . . . . . syn297N [H5N1],
. . . . . . . . syn323N,
. . . . . . . . syn413K [H2, H5N1, H9N2],
. . . . . . . . syn490P (CCg))
. . . . Tunisia1064_2010_01_18 (
. . . . . . . . syn30T,
. . . . . . . . syn181G,
. . . . . . . . syn182I,
. . . . . . . . 208K,
. . . . . . . . 225G,
. . . . . . . . 318S)
. . . . swThaiCURA4_2009_11 (
. . . . . . . . 226R,
. . . . . . . . 263D,
. . . . . . . . syn317L,
. . . . . . . . 318T,
. . . . . . . . syn350G,
. . . . . . . . 392H,
. . . . . . . . 414I,
. . . . . . . . syn484N)
. . . . Kansas03_2009_04_24_GQ168644 (
. . . . . . . . #1T,
. . . . . . . . syn161Y [H3N8 2009, H6N1, H9N2],
. . . . . . . . 186P mix,
. . . . . . . . syn456L)
. . . . Egypt114_2009_12_06 (
. . . . . . . . #1T,
. . . . . . . . 225E,
. . . . . . . . 300S,
. . . . . . . . 502K
. . . . . . . . syn512R)
. . . . SingGP2362_2010_05_18 (
[HA match to Oz_Victoria800_2010_06_02]
. . . . . . . . syn44L,
. . . . . . . . syn106E,
. . . . . . . . 128D,
. . . . . . . . 377K,
. . . . . . . . 502K,
. . . . . . . . syn529L (CTa) [UKWhiteChapel4880374_2010_11_28]
Lab Notes
377G
Origination Eval
[H2N3],
[H5N1 Human Egypt Preschool 2009, H5N1 Human Indonesia 2005],
[H6N1 2009],
[Avian H1N1, tn]
[UKLiverpool_1951],
[1918]
H2N3 Extensive incl
swMO4296424_2006
avian Alaska 2007
avian MN 2008
H5N1 wt GGA
CAAAAGGCAATAGATGgG
CAAAgGGCAATAGATGgG = 4526
Indonesia160H_2005_11_08
EgyptN04823_4M_2009_05_25, Sharqeya
EgyptN04526_4M_2009_05_18, Daqahleya.
dkEgypt0877NLQP_2008_04_15
140727_muscdkViet48_2007
H6N1 wt GGA
tkBelgium1865/2009
tkBelgium19842/2008
mallMaryland887_2002
mallOhio249/1998
mallALB730/1981
tealAustralia1/1979
dkPA486/1969
1. Ellis J, Galiano M, Pebody R, Lackenby A, Thompson C, Bermingham A, McLean E, Zhao H, Bolotin S, Dar O, Watson JM, Zambon M. Virological analysis of fatal influenza cases in the United Kingdom during the early wave of influenza in winter 2010/11. Euro Surveill. 2011;16(1):pii=19760. Available online: http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=19760
