UK Sequences from 2009 Document Transmission of TamiFlu Resistance

The UK Health Protection Agency released a set of 38 English sequences on 2010-01-04 at GenBank, but not from the current 2010 severe wave. These 38 HA and NA publications are delayed more than one year, covering September 10 to November 25, 2009. No sequences are included from the pandemic wave currently circulating.

65% of the English sequences are cross-linked with HA syn413K and NA syn407V.  225E occurs in 5 sequences and 225G in 2 sequences. Person to person transmission of oseltamivir-resistance via NA H275Y is noted within a hematology unit that encompasses 15 of these 38 sequences. All but one of the anti-viral resistant sequences are on a cross-linked background. One simple drug resistant sequence carries 225G on the cross-linked background.

The drug-resistant 15 are unremarkable, but for their simplicity.  The 225G sequences and a representative sample of the anti-viral resistant sequences is presented after the complete listing of TmX sequence names sorted by date.


TamiFlu-Resistance by Date

• UKEngland94640080_2009_11_04_xL_TmX
• UKEngland94640078_2009_11_05_xL_TmX
• UKEngland94740137_2009_11_07_xL_TmX
• UKEngland00380009_2009_11_07_xL_TmX
• UKEngland94740049_2009_11_10_xL_TmX
• UKEngland94740139_2009_11_10_xL_TmX
• UKEngland00380013_2009_11_12_xL_TmX
• UKEngland94740138_2009_11_16_xL_TmX
• UKEngland94740140_2009_11_16_xL_TmX
• UKEngland94780019_2009_11_17_xL_TmX
• UKEngland00380015_2009_11_17_xL_TmX
• UKEngland00380018_2009_11_19_xL_TmX
• UKEngland94840152_2009_11_19_TmX
• UKEngland00380020_2009_11_20_xL_TmX
• UKEngland94840153_2009_11_20_xL_TmX

Representative Sequences

. . . . UKEngland93960032_2009_09_10_xL (
. . . . . . . . 225G,
. . . . . . . . 273A,
. . . . . . . . syn413K)

. . . . UKEngland94640080_2009_11_04_xL_TmX (
. . . . . . . . syn77S,
. . . . . . . . 225G,
. . . . . . . . syn413K)

. . . . UKEngland94740049_2009_11_10_xL_TmX (
. . . . . . . . syn77S,
. . . . . . . . syn413K,
. . . . . . . . 475N mix wt)

. . . . UKEngland00380018_2009_11_19_xL_TmX (
. . . . . . . . syn77S,
. . . . . . . . syn96G,
. . . . . . . . 237I,
. . . . . . . . syn413K)

. . . . UKEngland94840152_2009_11_19_TmX (
. . . . . . . . syn77S)

. . . . UKEngland94840153_2009_11_20_xL_TmX (
. . . . . . . . syn77S,
. . . . . . . . syn331G,
. . . . . . . . syn413K)

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