UK Severe Wave Demonstrates Diversity with Vaccine Escape Positional Changes

Last Updated 2011-01-12

The UK Health Protection Agency released a group of 37 sequences at GISAID dated 2010-01-05 that appeared sometime after that date. Some of the sequences in this deposit also appear on the Figure 3 Phylogenetic Tree from the HPA Eurosurveilance paper requested to be cited as:

Ellis J, Galiano M, Pebody R, Lackenby A, Thompson C, Bermingham A, McLean E, Zhao H, Bolotin S, Dar O, Watson JM, Zambon M. Virological analysis of fatal influenza cases in the United Kingdom during the early wave of influenza in winter 2010/11. Euro Surveill. 2011;16(1):pii=19760.
Available online:
http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=19760
Date of submission: 31 December 2010

Amino acid positions 156, 158 and 159 have been tracked in the ΣPF11 reservoir with changes associated to multiple "Low Reactor" specimens. 

188T with 225G - UKEngland4880378_2010_12 [Link]
188T with 158E - UKEngland106_2010_11

Where is 188T with 158E and 225G similar to domained 156E, 188T and 225G on OzBrisbane209_51F_2010_08_09?

GeneWurx_UK_December_Emerging_Genetics_v4.xls

. . . . UKEngland106_2010_11 (
. . . . . . . . 0A,
. . . . . . . . syn55L,
. . . . . . . . 158E mix wt,
. . . . . . . . 188T,
. . . . . . . . syn258F [RussiaPermCREI_ZTS_2009_11_30
. . . . . . . . . . . . . . . . . . with 0A, 377K],
. . . . . . . . syn338G,
. . . . . . . . 377K,
. . . . . . . . 452I [H3N8 nucleotide donor],
. . . . . . . . . . . . [H11 nucleotide donor],
. . . . . . . . 454N,
. . . . . . . . syn529L)

. . . . UKEngland3380426_2010_08 (
. . . . . . . . syn44L,
. . . . . . . . syn106E,
. . . . . . . . 128D,
. . . . . . . . 159K [NY3230_2010_01_25
. . . . . . . . . . . . with 100N, syn177L, syn231N],
. . . . . . . . 377K)

Though neither of these two UK sequences are specfied as "Low Reactor", their inclusion indicates not only the divergency of the reservoir at this point, but also the ongoing potential for Vaccine Escape.

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