Mid-Life Travels of HA 275A, A Companion of the 230I Receptor Binding Domain Revision

Last Updated 2010-11-16

Apparently, friends travel together.

But not always in exactly the same passenger car, yet frequently on the same train.

Long trips may be passed in tolerable companionship that may involve discretion on one day and deepening fondness on the next, depending on the prevailing circumstances of the moment. 

Imagine a day on the railway . . . four friends, one accompanied with a new acquaintance.  In the afternoon, the initiate may rest while the others get some fresh air on the back of the dining car. After 10 minutes of glorious landscape, a howling wind breaks the party into timid and bold, with the bold holding ground until soaked by an instant shower. That mutual embarrassment may align the two rinsed travellers more than once on the duration of this trip for, after all, folly loves a jest. 

Sometimes, the oddest of circumstances, the unexpected, harnesses an attraction.

At 4 P.M., the two sensible travellers may take tea together while the others repose themselves to separate rooms for mid-day study. The entire comaraderie, finding themselves famished at the dinner hour and in want of company, may unsettle the maitre'd.  Practically re-orienting the room, pushing tables together, bustling in and out of the other passengers without such companionship, they eat and drink while recalling one to the other all the fine destinations they've visited.  With a toast, they tell tales and communicate their paths of felicity to the others.  Communication spawns ideas and enlivens standing plans.

Apparently, many of the RnR * polymorphisms that are found in this pandemic are friends . . . polite acquaintances at the bare minimum.  In communication.  Underway.

A virus does not halt when mere mankind votes and resolves that a pandemic is complete.  The virus that spawned the 1918 tragic waves, killing 50 to 100 million people, continued in progress for at least 13 years in humans and is yet at work today.  Have you read the press releases from that era of unapologised public health failure? 

Resolve yourself that pandemic viral reservoirs do not read press releases, nor relent at the political stoke of a pen.

Let the observational science do the talking. 

Read the sequences.

. . . . GuamNHRC0016_2009_09_04 (
. . . . . . . . 182V [1918, tn, H3N8, H4, H6N1, H7N3, H11],
. . . . . . . . . . . . . [NY7480_2010_03_01
. . . . . . . . . . . . . . . . . with 5 Avian Influenza polymorphisms,
. . . . . . . . . . . . . Boston103_2009_06_15],
. . . . . . . . syn231N [NY3230_2010_01_25
. . . . . . . . . . . . . . . . . with 100N, 159K, syn213F, syn177L,
. . . . . . . . . . . . . . Lisboa104_2009_12_22,
. . . . . . . . . . . . . . SingaporeGP4309_2009_11_12 with 377K,
. . . . . . . . . . . . . . HondurasAF2214_2009_10_20,
. . . . . . . . . . . . . . CalifVRDL36_2009_09_24 with 377K,
. . . . . . . . . . . . . . JapanNHRC0004_2009_08_04,
. . . . . . . . . . . . . . GuamNHRC0010_2009_07_21, et al],
. . . . . . . . 275A mix,
. . . . . . . . . . . . . [First Found in
. . . . . . . . . . . . . Stockholm35_2009_06_01
. . . . . . . . . . . . . traveler from United States],
. . . . . . . . syn538F [NY7426_2009_12_08 with 0I,
. . . . . . . . . . . . . . JapanNHRC0004_2009_08_04,
. . . . . . . . . . . . . . GuamNHRC0010_2009_07_21, et al]),

. . . . CalifAF2123_2009_10_14 (
. . . . . . . . 275A [First Found in
. . . . . . . . . . . . Stockholm35_2009_06_01
. . . . . . . . . . . . traveler from United States],
. . . . . . . . 377K,
. . . . . . . . HA truncated after aa386)

. . . . ColoradoAF2140_2009_10_06 (
. . . . . . . . syn66G [China (2) 2010_02_02 & 02_23,
. . . . . . . . . . . . . TexasJMS404_2010_01_08 with syn179L,
. . . . . . . . . . . . . TexasJMS401_2010_01_03 with 377K,
. . . . . . . . . . . . . Hawaii (2) 2010_01_02 & 01_03,
. . . . . . . . . . . . . Cyprus5494_2009_12_16,
. . . . . . . . . . . . . Arizona20_CXC1_2009_12_06,
. . . . . . . . . . . . . Nepal (2) beginning 2009_11_16,
. . . . . . . . . . . . . TverIIV2969_2009_11_14_xl_f with 225G,
. . . . . . . . . . . . . Japan (3) beginning 2009_10_23,
. . . . . . . . . . . . . England93280011_2009_08,
. . . . . . . . . . . . . Ancona17_2009_07_17,
. . . . . . . . . . . . . WiscS0208_2009_06_09],
. . . . . . . . 166N,
. . . . . . . . 275A [First Found in
. . . . . . . . . . . . Stockholm35_2009_06_01
. . . . . . . . . . . . traveler from United States],
. . . . . . . . HA truncated after aa386)

Changes at and around amino acid 275 are associated with M230I conversion in the Receptor Binding Domain.  275A is strongly associated.

Two sequences from the US, NY3230_2010_01_25 and Indiana21_2009_12_01, provide potential for interchange between the Russian / Eastern European sequences carrying syn177L and the recently profiled emerging sub-clade from the US and the Ukraine during April to June 2010.

Supporting Sequences

. . . . Finland655_2009_10_20 (
. . . . . . . . syn120F,
. . . . . . . . 275A,
. . . . . . . . 317M [Finland,
. . . . . . . . . . . . . Athens,
. . . . . . . . . . . . . Kuwait,
. . . . . . . . . . . . . Japan,
. . . . . . . . . . . . . Kansas,
. . . . . . . . . . . . . Texas,
. . . . . . . . . . . . . Wisconsin])

. . . . Finland665_2009_10_27 (
. . . . . . . . syn120F,
. . . . . . . . 275A,
. . . . . . . . 317M [Finland,
. . . . . . . . . . . . . Athens,
. . . . . . . . . . . . . Kuwait,
. . . . . . . . . . . . . Japan,
. . . . . . . . . . . . . Kansas,
. . . . . . . . . . . . . Texas,
. . . . . . . . . . . . . Wisconsin])

. . . . Finland2_2010_01_12 (
. . . . . . . . syn177L,
. . . . . . . . 222R,
. . . . . . . . 233H,
. . . . . . . . syn296Q,
. . . . . . . . 324I,
. . . . . . . . syn413K)

. . . . GreeceLivadia1851_2010_01_26 (
. . . . . . . . 132D,
. . . . . . . . syn177L,
. . . . . . . . 196L,
. . . . . . . . syn221P,
. . . . . . . . 222Q,
. . . . . . . . 276Q,
. . . . . . . . 373H,
. . . . . . . . syn420D)

Please refer to additional studies for further genetic analyses, including the survey on amino acid revisions potentially related to Vaccine Escape.  A hyper-morphic, TamiFlu-resistant sequence from the state of Washington in Spring 2010 has recently been profiled with similar zoonotic influences.



* Rare, not Random.

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