Sweden Fatality Sequence Demonstrates Role of Scandinavia in FlightPath Between US and Russia

Last Updated
2011-03-29

Clinical outcome was provided by the Swedish Institute for Infectious Disease Control in deposits at GISAID made between January and March of 2010.  Three HA sequences are marked as "post-mortem" and/or "deceased". 

The October and December sequences carry 225E with a minimal number of changes.

The fatal, cross-linked November case from Orebro shows a potentially zoonotic silent 177L-forming Single Nucleotide Polymorphism (SNP) with a notable FlightPath.  The synonymous revision had an early appearance in Wisconsin, is well-represented on the population of 9 cross-linked Russian fatalities and has recently traveled to New York and Nagasaki.

. . . . SwedenOrebro1_2009_11_02_xL_f  (
. . . . . . . . syn177L [H3N8, H6, H7N7],
. . . . . . . . . . . . . . [NagasakiHA_10_30_2010_03_29 with 513V, 550K,
. . . . . . . . . . . . . . NagasakiHA_10_27_2010_03_15 with 513V, 550K,
. . . . . . . . . . . . . . NY3230_2010_01_25 with syn213F,
. . . . . . . . . . . . . . Kansas25_2009_12_07 with 50A,
. . . . . . . . . . . . . . Indiana21_2009_12_01 with 212E, 313K,
. . . . . . . . . . . . . . SwedenGothenburg2_2009_12_01_xL with 146G,
. . . . . . . . . . . . . . Tambov_LLA_2009_11_30_xL_f with 225G,
. . . . . . . . . . . . . . Perm01_2009_11_25_xL_f,
. . . . . . . . . . . . . . MoscowOb_ZNF_2009_11_24_xL_f,
. . . . . . . . . . . . . . Ivanovo_KOE_2009_11_25_xL_f,
. . . . . . . . . . . . . . Astrakhan_CHRM_2009_11_24_xL_f,
. . . . . . . . . . . . . . GreeceThessaloniki2812_2009_11_22,
. . . . . . . . . . . . . . Ivanovo_STV1_2009_11_21 with 225G,
. . . . . . . . . . . . . . NorwayOslo110_2009_11_10,
. . . . . . . . . . . . . . MoscowOb_STV_2009_11_09_f with 225N,
. . . . . . . . . . . . . . GermanyNiedersachsen352_2009_11_05,
. . . . . . . . . . . . . . MoscowOb_OAM_2009_11_02_xL_f with 225G,
. . . . . . . . . . . . . . MoscowOb_DEI_2009_11_xL_f with 225G,
. . . . . . . . . . . . . . Ivanovo_AMV_2009_11_xL_f with 225G,
. . . . . . . . . . . . . . BelgiumBrussels106_2009_10_29,
. . . . . . . . . . . . . . Moscow_BVA_2009_10_24_xL_f with 225G,
. . . . . . . . . . . . . . SwedenUmea8_2009_10_07 with 0I, 244I,
. . . . . . . . . . . . . . Norway3364_2_2009_09_08_xL,
. . . . . . . . . . . . . . DenmarkAarhus82_2009_xL,
. . . . . . . . . . . . . . Orenburg_VNV_2009_08_06_xL,
. . . . . . . . . . . . . . England2800004_2009_07,
. . . . . . . . . . . . . . WiscD0008_2009_06_04],
. . . . . . . . 324I,
. . . . . . . . syn413K [H9N2])

. . . . SwedenStockholm96_2009_10_04_f  (
. . . . . . . . #1T,
. . . . . . . . 225E,
. . . . . . . . HA truncated after aa251)

. . . . SwedenUmea13_2009_12_09_f  (
. . . . . . . . #7A,
. . . . . . . . 140S,
. . . . . . . . 225E)


Two sequences from the US, NY3230_2010_01_25 and Indiana21_2009_12_01, provide potential for interchange between the Russian / Eastern European sequences carrying syn177L and the recently profiled emerging sub-clade from the US and the Ukraine during April to June 2010.

Please refer to additional studies for further genetic analyses, including the survey on amino acid revisions potentially related to Vaccine Escape.  A hyper-morphic, TamiFlu-resistant sequence from the state of Washington in Spring 2010 has recently been profiled with similar zoonotic influences.

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