Last Updated 2010-10-26
In positions where this flu is revising the pandemic gene code, the ΣPF11 reservoir (pH1N1) presently exhibits a strong pattern of alliance with serotypes normally infecting birds, horses and dogs.
100% of the Hemagglutinin positions between 186 and 248, including antigenic areas of the Receptor Binding Domain (RBD/RBS), are on record as polymorphic. No position in that range is stable. Many positions rate multiple changes. Protein revision is now documented at 57 of the 63 positions (90%), engaging the potential for antibody resistance (natural immune escape and vaccine escape).
The Shiraz University of Medical Science released a group of sequences today at GenBank. Each demonstrates unusual characteristics. One stands above the others. IranShiraz1_2010_02 carries a previously unseen Receptor Binding Domain revision, 228R, alongside changes found recently in the H10N7 reservoir. Of interest is the fact that changes at or around amino acid position 238 and changes at or around 275 are associated with an emerging sub-clade that is permissive to and demonstrates the M230I polymorphism.
Is 228R another tertiary Immune Escape marker similar in mechanism to 230I? Iran has also documented 227Q in the reservoir on a hyper-morphic sample, Iran15583_2009_11_21.
. . . . IranShiraz1_2010_02 (
. . . . . . . . 88T,
. . . . . . . . 90K,
. . . . . . . . 91W,
. . . . . . . . syn218A [WSN33],
. . . . . . . . . . . . . . . [Nebraska02_2010_03_11
. . . . . . . . . . . . . . . . . . . . . .with 523A,
. . . . . . . . . . . . . . . CubaHabana2687_2009
. . . . . . . . . . . . . . . . . . . . . .with 221T]
. . . . . . . . 228R (cGG) [H9N2 2008 (AGA)],
. . . . . . . . 238Q [H10N7 2009],
. . . . . . . . 246Q,
. . . . . . . . 277N [H5N1, H10N7 2009],
. . . . . . . . . . . . . [Iran15583_2009_11_21,
. . . . . . . . . . . . . Wisconsin],
. . . . . . . . syn350G [swThaiCURA4_2009_11
. . . . . . . . . . . . . . . . . . . with 226R, syn484N])
2010-10-16
230I Permissive Sub-Clade Expanded via June 2010 Sequence from South Africa
Last Updated 2010-10-16
Another distinct geographic area is inserted into the January to August 2010 Expansion of the emerging 230I-Permissive PF11 Hydra.
From 2010-08-07 through 2010-09-27, GeneWurx discussed the spread of one remarkable Hydra across the US, Germany and the Ukraine. HA 230I is represented in this sub-clade on a sequence from the US state of Minnesota. HA 225G (GGt) entered the sub-clade in the US state of Pennsylvania. The sub-clade appears to be one of several that are permissive to a combination of 225G (GGt) and 230I within post-pandemic H1N1.
On 2010-10-14, the UK National Institute for Medical Research released a set of sequences at GISAID, primarily fromAfrica . CapeTown29_24M_2010_06_08, originated by the Sandringham National Institute for Communicable Disease, was sampled from a 24 year old male. No clinical information is provided, nor outcome.
The sequence carries 9 polymorphisms on the HA alone and typifies the rapid genetic acquisition. Six of those changes place the sequence with 12 other cases across the United States, the Ukraine and Germany.
Follow 6 HA polymorphisms (3 silent) tracing onto this 13th sequence through the 9th distinct geographic location:
34D, 165N, 189T, syn213F, syn305K, syn346G.
Five of the six polymorphisms are found in animal influenza reservoirs (zoonotic) and the sixth shares nucleotide homology with recognised zoonotic reservoirs. Does this Hydra link the US to flu strains from the Ukraine, India or Russia?
. . . . CapeTown29_24M_2010_06_08 (
. . . . . . . . 34D,
. . . . . . . . 165N,
. . . . . . . . 189T,
. . . . . . . . syn213F,
. . . . . . . . 275I,
. . . . . . . . syn287G,
. . . . . . . . syn305K,
. . . . . . . . syn346G,
. . . . . . . . 382I [NY2372_2010_01_20
. . . . . . . . . . . . . . . . . with 128D, 233H, 273A, syn283Q,
. . . . . . . . . . . . NewZealandWaikato2_2010_01_04
. . . . . . . . . . . . . . . . . with 233H, syn283Q,
. . . . . . . . . . . . NY_INS317_2009_12_17
. . . . . . . . . . . . . . . . . with 233H, 273A, syn283Q,
. . . . . . . . . . . . Hawaii28_2009_10_10
. . . . . . . . . . . . . . . . . with 159D,
. . . . . . . . . . . . Cameroon357_2009_08_08
. . . . . . . . . . . . . . . . . with 225E])
Please refer to additional studies for further genetic analyses, including the survey on amino acid revisions potentially related to Vaccine Escape. A hyper-morphic, TamiFlu-resistant sequence from the state of Washington in Spring 2010 has recently been profiled with similar zoonotic influences.
Previous Study on this Topic:
Another distinct geographic area is inserted into the January to August 2010 Expansion of the emerging 230I-Permissive PF11 Hydra.
From 2010-08-07 through 2010-09-27, GeneWurx discussed the spread of one remarkable Hydra across the US, Germany and the Ukraine. HA 230I is represented in this sub-clade on a sequence from the US state of Minnesota. HA 225G (GGt) entered the sub-clade in the US state of Pennsylvania. The sub-clade appears to be one of several that are permissive to a combination of 225G (GGt) and 230I within post-pandemic H1N1.
On 2010-10-14, the UK National Institute for Medical Research released a set of sequences at GISAID, primarily from
The sequence carries 9 polymorphisms on the HA alone and typifies the rapid genetic acquisition. Six of those changes place the sequence with 12 other cases across the United States, the Ukraine and Germany.
Follow 6 HA polymorphisms (3 silent) tracing onto this 13th sequence through the 9th distinct geographic location:
34D, 165N, 189T, syn213F, syn305K, syn346G.
Five of the six polymorphisms are found in animal influenza reservoirs (zoonotic) and the sixth shares nucleotide homology with recognised zoonotic reservoirs. Does this Hydra link the US to flu strains from the Ukraine, India or Russia?
. . . . CapeTown29_24M_2010_06_08 (
. . . . . . . . 34D,
. . . . . . . . 165N,
. . . . . . . . 189T,
. . . . . . . . syn213F,
. . . . . . . . 275I,
. . . . . . . . syn287G,
. . . . . . . . syn305K,
. . . . . . . . syn346G,
. . . . . . . . 382I [NY2372_2010_01_20
. . . . . . . . . . . . . . . . . with 128D, 233H, 273A, syn283Q,
. . . . . . . . . . . . NewZealandWaikato2_2010_01_04
. . . . . . . . . . . . . . . . . with 233H, syn283Q,
. . . . . . . . . . . . NY_INS317_2009_12_17
. . . . . . . . . . . . . . . . . with 233H, 273A, syn283Q,
. . . . . . . . . . . . Hawaii28_2009_10_10
. . . . . . . . . . . . . . . . . with 159D,
. . . . . . . . . . . . Cameroon357_2009_08_08
. . . . . . . . . . . . . . . . . with 225E])
Please refer to additional studies for further genetic analyses, including the survey on amino acid revisions potentially related to Vaccine Escape. A hyper-morphic, TamiFlu-resistant sequence from the state of Washington in Spring 2010 has recently been profiled with similar zoonotic influences.
Previous Study on this Topic:
- 2010-08-07 HA Spreads Across US and Travels to the Ukraine Again
- 2010-09-27 225G Sequence from Pennsylvania Extends Sub-Clade with Fatality Markers from Russia and Brasil
2010-09-27
225G Sequence from Pennsylvania Extends Sub-Clade with Fatality Markers from Russia and Brasil
Last Updated 2011-03-29
January to August 2010 Expansion of One Hydra
On 2010-08-07 and the following weeks, GeneWurx discussed the spread of one remarkable Hydra across the US, Germany and the Ukraine. HA 230I is represented in this sub-clade on a sequence from the US state of Minnesota. HA 225G (GgT) now enters this sub-clade in the US state of Pennsylvania. The sub-clade appears to be one of several that are permissive to a combination of 225G (GgT) and 230I within post-pandemic H1N1.
On 2010-09-24, the US CDC released a set of sequences at GISAID that included six from the United States. Pennsylvania07_2010_08_12 was sampled from a 24 year old female. No clinical information is provided, nor outcome.
The sequence carries 13 polymorphisms on the HA alone and typifies the rapid genetic acquisition that continues on the most current samples in the United States. Six of those changes place the sequence with 11 other cases across the United States, the Ukraine and Germany.
Follow 6 HA polymorphisms (3 silent) tracing onto this 12th sequence through the 8th distinct geographic location:
34D, 165N, 189T, syn213F, syn305K, syn346G.
Five of the six polymorphisms are found in animal influenza reservoirs (zoonotic) and the sixth shares nucleotide homology with recognised zoonotic reservoirs. Is this another strain linking the US to flu strains from the Ukraine, India or Russia?
. . . . Pennsylvania07_2010_08_12 (
. . . . . . . . 34D,
. . . . . . . . syn118E,
. . . . . . . . 140T,
. . . . . . . . 165N,
. . . . . . . . 189T,
. . . . . . . . syn213F,
. . . . . . . . 225G (GgT),
. . . . . . . . 275I,
. . . . . . . . syn287G,
. . . . . . . . syn305K,
. . . . . . . . syn329S,
. . . . . . . . syn346G,
. . . . . . . . 451E [Unique to Japan])
Please refer to additional studies for further genetic analyses, including the survey on amino acid revisions potentially related to Vaccine Escape. A hyper-morphic, TamiFlu-resistant sequence from the state of Washington in Spring 2010 has recently been profiled with similar zoonotic influences.
Previous Study on this Topic:
January to August 2010 Expansion of One Hydra
On 2010-08-07 and the following weeks, GeneWurx discussed the spread of one remarkable Hydra across the US, Germany and the Ukraine. HA 230I is represented in this sub-clade on a sequence from the US state of Minnesota. HA 225G (GgT) now enters this sub-clade in the US state of Pennsylvania. The sub-clade appears to be one of several that are permissive to a combination of 225G (GgT) and 230I within post-pandemic H1N1.
On 2010-09-24, the US CDC released a set of sequences at GISAID that included six from the United States. Pennsylvania07_2010_08_12 was sampled from a 24 year old female. No clinical information is provided, nor outcome.
The sequence carries 13 polymorphisms on the HA alone and typifies the rapid genetic acquisition that continues on the most current samples in the United States. Six of those changes place the sequence with 11 other cases across the United States, the Ukraine and Germany.
Follow 6 HA polymorphisms (3 silent) tracing onto this 12th sequence through the 8th distinct geographic location:
34D, 165N, 189T, syn213F, syn305K, syn346G.
Five of the six polymorphisms are found in animal influenza reservoirs (zoonotic) and the sixth shares nucleotide homology with recognised zoonotic reservoirs. Is this another strain linking the US to flu strains from the Ukraine, India or Russia?
. . . . Pennsylvania07_2010_08_12 (
. . . . . . . . 34D,
. . . . . . . . syn118E,
. . . . . . . . 140T,
. . . . . . . . 165N,
. . . . . . . . 189T,
. . . . . . . . syn213F,
. . . . . . . . 225G (GgT),
. . . . . . . . 275I,
. . . . . . . . syn287G,
. . . . . . . . syn305K,
. . . . . . . . syn329S,
. . . . . . . . syn346G,
. . . . . . . . 451E [Unique to Japan])
Please refer to additional studies for further genetic analyses, including the survey on amino acid revisions potentially related to Vaccine Escape. A hyper-morphic, TamiFlu-resistant sequence from the state of Washington in Spring 2010 has recently been profiled with similar zoonotic influences.
Previous Study on this Topic:
2010-09-26
HA 230I RBS Polymorphism Potential for Pennsylvania
Current trending indicates a reportable potential for the M230I polymorphism spreading on the Hemagglutinin of PF11. This Receptor Binding Domain change may enhance Vaccine Escape from the currently selected vaccine target candidate, CA/07 X181.
For those who are following the prediction on February 25, 2010, the pandemic reservoir now shows multiple instances of multiple encodings for 230I. Model adjustment and data transparency allowed a second set of detailed geographic predictions on 2010-08-09 that have also found traction.
The 230I bearing sequences meeting the prediction are documented in the detailed discussion on Vaccine Escape that demonstrates a 100% change rate in the pandemic influenza (pH1N1) reservoir at the critical HA genetics range between amino acid positions 186 and 248. 89% of the amino acid positions have notated revisions.
Expectations for the M230I polymorphism, that first came to our notice for zoonotic concern on the H5N1 human fatality cluster, have now been revised based on the most current public data. The GeneWurx model approximates that HA 230I will appear in the PF11 RBS according to the following geographic probabilities.
For those who are following the prediction on February 25, 2010, the pandemic reservoir now shows multiple instances of multiple encodings for 230I. Model adjustment and data transparency allowed a second set of detailed geographic predictions on 2010-08-09 that have also found traction.
The 230I bearing sequences meeting the prediction are documented in the detailed discussion on Vaccine Escape that demonstrates a 100% change rate in the pandemic influenza (pH1N1) reservoir at the critical HA genetics range between amino acid positions 186 and 248. 89% of the amino acid positions have notated revisions.
Expectations for the M230I polymorphism, that first came to our notice for zoonotic concern on the H5N1 human fatality cluster, have now been revised based on the most current public data. The GeneWurx model approximates that HA 230I will appear in the PF11 RBS according to the following geographic probabilities.
- 45% probability in Pennsylvania sampled by 2011-01-01.
2010-09-24
Pandemic Influenza and Avian Influenza Conjunctivitis Presentation
Last Updated 2010-09-30
Large outbreaks of eye inflammation (conjunctivitis), including hemorrhagic conjunctivitis, have begun around the world this month with several regions registering case counts in the thousands. Viral infection is frequently associated with this type of highly contagious "Pink Eye" or "Red Eye". Early pandemic H1N1 cases document these types of eye redness in the patient symptomology.
One recent HA polymorphism found in the pandemic reservoir has been previously associated with viral conjunctivitis with and without classic influenza symptoms. The amino acid value of HA 188T is strongly correlated to conjunctivitis on the Netherlands human H7N7 outbreak during 2003, including zoonoses from commercial poultry operatons. One human fatality was recorded during that outbreak and that case sequence shows the HA 188T.
Avian influenza again may be communicating with the human pandemic H1N1 Hydrae. India today, 2010-09-30, is on record in a section of Mumbai as counting 2,500 cases of conjunctivitis this month. HA 188T is also found in India.
. . . . Florida14_24M_2010_08_05 (
. . . . . . . . 100N [H7N3, H7N7, H9N2],
. . . . . . . . syn161Y [H3N8 2009, H6N1, H9N2],
. . . . . . . . 188T [H6N1, H7N7],
. . . . . . . . syn338G [H3N8, H4, H5, H6, sw],
. . . . . . . . 377K [H9N2],
. . . . . . . . 442I mix,
. . . . . . . . 454N [H7N3, H7N7, H9N2])
. . . . OZVictoria512_2010_07_30 (
. . . . . . . . syn60I,
. . . . Thailand34_9912_2010_07_14 (
. . . . . . . . HA truncated after aa253)
. . . . Thailand34_9937_2010_07_14 (
. . . . . . . . 162Q [Unique to PF11 GenBank/GISAID],
. . . . NZChristchurch15_2010_07_12 (
. . . . . . . . 100N,
. . . . India5107_2010_06_28 (
. . . . . . . . syn60I,
. . . . India8910_2010_05_08 (
. . . . . . . . syn49G [H7N3, H7N7],
. . . . . . . . syn51A,
. . . . swThaiCURA75_2010_01 (
. . . . . . . . syn350G [H7N3, H7N7],
. . . . . . . . 414I,
The human post-pandemic reservoir continues to diversify and augment from a wide variety of avian, canine and equine sources. Sampling and sequence confirmation may corroborate that Mexico, China or Pakistan has HA 188T in the PF11 reservoir near the same geographies where the eye symptoms are occurring.
Large outbreaks of eye inflammation (conjunctivitis), including hemorrhagic conjunctivitis, have begun around the world this month with several regions registering case counts in the thousands. Viral infection is frequently associated with this type of highly contagious "Pink Eye" or "Red Eye". Early pandemic H1N1 cases document these types of eye redness in the patient symptomology.
One recent HA polymorphism found in the pandemic reservoir has been previously associated with viral conjunctivitis with and without classic influenza symptoms. The amino acid value of HA 188T is strongly correlated to conjunctivitis on the Netherlands human H7N7 outbreak during 2003, including zoonoses from commercial poultry operatons. One human fatality was recorded during that outbreak and that case sequence shows the HA 188T.
- Transmission of H7N7 avian influenza A virus to human beings during a large outbreak in commercial poultry farms in the Netherlands.
- Avian influenza A virus (H7N7) associated with human conjunctivitis and a fatal case of acute respiratory distress syndrome.
Avian influenza again may be communicating with the human pandemic H1N1 Hydrae. India today, 2010-09-30, is on record in a section of Mumbai as counting 2,500 cases of conjunctivitis this month. HA 188T is also found in India.
. . . . Florida14_24M_2010_08_05 (
. . . . . . . . 100N [H7N3, H7N7, H9N2],
. . . . . . . . syn161Y [H3N8 2009, H6N1, H9N2],
. . . . . . . . 188T [H6N1, H7N7],
. . . . . . . . syn338G [H3N8, H4, H5, H6, sw],
. . . . . . . . 377K [H9N2],
. . . . . . . . 442I mix,
. . . . . . . . 454N [H7N3, H7N7, H9N2])
. . . . OZVictoria512_2010_07_30 (
. . . . . . . . syn60I,
. . . . . . . . 100N [H7N3, H7N7, H9N2],
. . . . . . . . 188T [H6N1, H7N7],
. . . . . . . . syn285P,. . . . . . . . syn338G [H3N8, H4, H5, H6, sw],
. . . . . . . . 377K [H9N2],
. . . . . . . . 454N [H7N3, H7N7, H9N2])
. . . . Thailand34_9912_2010_07_14 (
. . . . . . . . 188T [H6N1, H7N7],
. . . . . . . . 200T, . . . . . . . . HA truncated after aa253)
. . . . Thailand34_9937_2010_07_14 (
. . . . . . . . 162Q [Unique to PF11 GenBank/GISAID],
. . . . . . . . 188T [H6N1, H7N7],
. . . . . . . . HA truncated after aa253). . . . NZChristchurch15_2010_07_12 (
. . . . . . . . 100N,
. . . . . . . . 188T [H6N1, H7N7],
. . . . . . . . syn338G [H3N8, H4, H5, H6, sw],
. . . . . . . . 377K [H9N2],
. . . . . . . . 454N [H7N3, H7N7, H9N2])
. . . . India5107_2010_06_28 (
. . . . . . . . syn60I,
. . . . . . . . 100N [H7N3, H7N7, H9N2],
. . . . . . . . syn135V,
. . . . . . . . 188T [H6N1, H7N7],
. . . . . . . . syn338G [H3N8, H4, H5, H6, sw],
. . . . . . . . 377K [H9N2],
. . . . . . . . 454N [H7N3, H7N7, H9N2])
. . . . . . . . syn49G [H7N3, H7N7],
. . . . . . . . syn51A,
. . . . . . . . 188T [H6N1, H7N7],
. . . . . . . . syn338G [H3N8, H4, H5, H6, sw],
. . . . . . . . 377K [H9N2],
. . . . . . . . 454N [H7N3, H7N7, H9N2])
. . . . swThaiCURA75_2010_01 (
. . . . . . . . 188T [H6N1, H7N7],
. . . . . . . . 263D, . . . . . . . . syn350G [H7N3, H7N7],
. . . . . . . . 414I,
. . . . . . . . syn484N [H3N8, H4, H5N1 (E/A/H), H6, H7N7, H9N2, H11])
The human post-pandemic reservoir continues to diversify and augment from a wide variety of avian, canine and equine sources. Sampling and sequence confirmation may corroborate that Mexico, China or Pakistan has HA 188T in the PF11 reservoir near the same geographies where the eye symptoms are occurring.
2010-09-19
Australia Shows Novel HA 238D in August 2010 on Hyper-morphic Sequence
The WHO Collaborating Centre for Reference and Research on Influenza deposited a group of 74 sequences on 2010-09-15 primarily from Australia and New Zealand with 9 from Asia and 2 from Oceania (Fiji and Papua New Guinea).
A nine year old female patient from Little River, Victoria, Australia was sampled by the Monash Medical Centre on 2010-07-24 during the current influenza epidemic. That sequence, OzVictoria508_9F_2010_07_24, is one of only six in this deposit without an antigenic characterisation. The HA gene segment carries 14 polymorphisms.
Significant homology exists with H5N1 and H7N7. Changes at amino acid position 238 and the region are associated with the 230I polymorphism. With the numerous polymorphisms and the lack of antigenic testing, this sequence is suggestive of immune escape tendencies.
The continual building of changes onto the pandemic H1N1 background requires ongoing surveillance. Genetic data continues to ebb from Asia, India and Oceania into Fall European and North American sequences. India is represented in the conforming predecessor polymorphism list for this Australian sequence. Finding similar genetic quality in the near future is a reasonable expectation for the upcoming North American epidemic.
. . . . OzVictoria508_9F_2010_07_24 (
. . . . . . . . 35I [H5N1],
. . . . . . . . 88P [H2N3, H5N1, H11],
. . . . . . . . . . . [HunanHechengSWL1616_2009-11-23,
. . . . . . . . . . . KoreaAF2376_2009_10_27
. . . . . . . . . . . . . . . with 280A and 290K
. . . . . . . . . . . Nevada15_9F_2009_09_10
. . . . . . . . . . . . . . . with 22I, 225E, 256F, 299Y,
. . . . . . . . . . . . . . . . . . 299Y, 300S, syn384S,
. . . . . . . . . . . GermanyCologne13_2009_06_29
. . . . . . . . . . . . . . . with 35I, 38V, syn108L,
. . . . . . . . . . . . . . . . . . syn205G, 206s, syn276H],
. . . . . . . . syn102E [SingON2407_2009_12_13,
. . . . . . . . . . . . . . . Singapore544_2009_12_10,
. . . . . . . . . . . . . . . Brussels243_2009_11_09
. . . . . . . . . . . . . . . . . . . . with syn44L and 89G],
. . . . . . . . syn152I [CalifVRDL115_2009_12_04,
. . . . . . . . . . . . . . . NY6939_2009_12_11,
. . . . . . . . . . . . . . . tkOntarioFAV117_1C_2009_12_07
. . . . . . . . . . . . . . . . . . . . with 35I, syn219I, syn276H,
. . . . . . . . . . . . . . . . . . . . . . . syn456L, 463V, 523A,
. . . . . . . . . . . . . . . England1050_2009_12,
. . . . . . . . . . . . . . . Scotland103_2009_12,
. . . . . . . . . . . . . . . England1051_2009_12,
. . . . . . . . . . . . . . . ItalyAncona451_2009_11_27_f,
. . . . . . . . . . . . . . . NY6607_2009_11_24,
. . . . . . . . . . . . . . . CalifVRDL107_2009_11_15,
. . . . . . . . . . . . . . . CalifVRDL101_2009_11_05,
. . . . . . . . . . . . . . . DC_114_2009_11_04,
. . . . . . . . . . . . . . . England94800096_2009_11,
. . . . . . . . . . . . . . . Calif_SD35_2009_10_26,
. . . . . . . . . . . . . . . NY5447_2009_10_23,
. . . . . . . . . . . . . . . CalifVRDL84_2009_10_09,
. . . . . . . . . . . . . . . CalifVRDL87_2009_10_09,
. . . . . . . . . . . . . . . IndiaPune6196_2009_08,
. . . . . . . . . . . . . . . IndiaDhule9433_2009_08,
. . . . . . . . . . . . . . . SantoDomingoWR1057N_2009_07_02,
. . . . . . . . . . . . . . . SantoDomingoWR1058N_2009_07_02,
. . . . . . . . . . . . . . . SantoDomingoWR1059N_2009_06_30],
. . . . . . . . 206S,
. . . . . . . . syn219I [CalifVRDL115_2009_12_04
. . . . . . . . . . . . . . . . . with 35I, syn152I, syn276H,
. . . . . . . . . . . . . . . . . . . . syn456L, 463V, 523A,
. . . . . . . . . . . . . . FL_Pen213_2009_11_17
. . . . . . . . . . . . . . . . . . . . with 35I, syn152I, 273A,
. . . . . . . . . . . . . . . . . . . . syn456L, 463V, 523A,
. . . . . . . . . . . . . . CalifVRDL107_2009_11_15
. . . . . . . . . . . . . . . . . . . . with 35I, syn152I, syn276H,
. . . . . . . . . . . . . . . . . . . . syn456L, 463V, 523A,
. . . . . . . . 238D (GAc) [H2N3, H7N3, H7N7],
. . . . . . . . . . . . . . . . . . [Belgorod2_2010-03-15 (GAt),
. . . . . . . . . . . . . . . . . . Kaliningrad01_2009_11_02 (GAt)
. . . . . . . . . . . . . . . . . . . . . . . . with 225E and 226R,
. . . . . . . . . . . . . . . . . . AthensINS398_2010-01-24 GAt),
. . . . . . . . . . . . . . . . . . KaliningradCRIE_DA_2009-09-26 (GAt),
. . . . . . . . . . . . . . . . . . KaliningradCRIE_KG_2009-09-25 (GAt),
. . . . . . . . . . . . . . . . . . KaliningradCRIE_MA_2009-09-25 (GAt),
. . . . . . . . . . . . . . . . . . KaliningradCRIE_SHD_2009-09-25 (GAt),
. . . . . . . . . . . . . . . . . . KaliningradCRIE_ZD_2009-09-25 (GAt)],
. . . . . . . . syn247A [Belize8756_2009_10_08,
. . . . . . . . . . . . . . . Singapore93_2009_06_22]
. . . . . . . . syn254P,
. . . . . . . . 272G [Niigata19_2009_12_31,
. . . . . . . . . . . . GuangdongSWL36_2009_11_29],
. . . . . . . . syn276H [1918, S5],
. . . . . . . . syn388K [H5N1],
. . . . . . . . . . . . . . . [NagasakiHA_10_28_2010_03_23
. . . . . . . . . . . . . . . . . . . . . with 22I,
. . . . . . . . . . . . . . . NagasakiHA_10_26_2010_03_15
. . . . . . . . . . . . . . . . . . . . . with 22I, syn103E,
. . . . . . . . . . . . . . . NagasakiHA_10_24_2010_03_08
. . . . . . . . . . . . . . . . . . . . . with syn103E,
. . . . . . . . . . . . . . . GuangxiLonganSWL1990_2010_02_08
. . . . . . . . . . . . . . . . . . . . . with 453K, syn462E,
. . . . . . . . . . . . . . . JiangxiDonghuSWL15_2010_01_04
. . . . . . . . . . . . . . . . . . . . . with syn106E, 149R, syn456L (TTg),
. . . . . . . . . . . . . . . ViennaINS142_2009_11_26
. . . . . . . . . . . . . . . . . . . . . with syn97D, 99T,
. . . . . . . . . . . . . . . CzechUsti208_2009_11_25
. . . . . . . . . . . . . . . . . . . . . with 268T,
. . . . . . . . . . . . . . . GhanaFS_1921_2009_11_11,
. . . . . . . . . . . . . . . Alaska44_2009_11_17
. . . . . . . . . . . . . . . . . . . . . with syn275V, 276N,
. . . . . . . . . . . . . . . CalifVRDL76_2009_09_21
. . . . . . . . . . . . . . . . . . . . . with syn283Q,
. . . . . . . . . . . . . . . Taiwan206_2009_09_18,
. . . . . . . . . . . . . . . Taiwan177_2009_09_18,
. . . . . . . . . . . . . . . Taiwan167_2009_09_18,
. . . . . . . . . . . . . . . Taiwan156_2009_09_18,
. . . . . . . . . . . . . . . Taiwan143_2009_09_15
. . . . . . . . . . . . . . . . . . . . . with 205E mix,
. . . . . . . . . . . . . . . Utah20_C2_2_2009_07_25_VxX
. . . . . . . . . . . . . . . . . . . . . with 159D, 206S, 227G
. . . . . . . . . . . . . . . Slovenia2687_2009_07_01
. . . . . . . . . . . . . . . . . . . . . with 35I, 206S],
. . . . . . . . syn456L [H5N1],
. . . . . . . . 463V,
. . . . . . . . 523A [Nebraska02_2010_03_11,
. . . . . . . . . . . . NagasakiHA1022_2010_03_01_syn413K,
. . . . . . . . . . . . DomRepublic3768_2009_12_15,
. . . . . . . . . . . . NY6939_2009_12_11,
. . . . . . . . . . . . CalifVRDL115_2009_12_04,
. . . . . . . . . . . . NY6607_2009_11_24,
. . . . . . . . . . . . RheinlandPfalz81_2009_11_23,
. . . . . . . . . . . . Berlin210_2009_11_16,
. . . . . . . . . . . . BadenWurttemberg511_2009_11_16,
. . . . . . . . . . . . CalifVRDL107_2009_11_15,
. . . . . . . . . . . . FL_Pensacola40_2009_11_09,
. . . . . . . . . . . . CalifVRDL101_2009_11_05,
. . . . . . . . . . . . DC114_2009_11_04,
. . . . . . . . . . . . Calif_SD35_2009_10_26,
. . . . . . . . . . . . NY5447_2009_10_23,
. . . . . . . . . . . . CalifVRDL84_2009_10_09,
. . . . . . . . . . . . CalifVRDL87_2009_10_09,
. . . . . . . . . . . . KuwaitN13013_2009_08_31_syn413K])
Supporting Sequences
. . . . CalifVRDL115_2009_12_04 (
. . . . . . . . . . . . 35I [H5N1],
. . . . . . . . . . . . 77N,
. . . . . . . . . . . . syn152I,
. . . . . . . . . . . . syn219I,
. . . . . . . . . . . . syn276H [1918, S5],
. . . . . . . . . . . . syn456L [H5N1],
. . . . . . . . . . . . 463V,
. . . . . . . . . . . . 523A)
. . . . FL_Pen213_2009_11_17 (
. . . . . . . . . . . . 35I [H5N1],
. . . . . . . . . . . . syn152I,
. . . . . . . . . . . . syn219I,
. . . . . . . . . . . . 273A,
. . . . . . . . . . . . syn276H [1918, S5],
. . . . . . . . . . . . syn456L [H5N1],
. . . . . . . . . . . . 463V,
. . . . . . . . . . . . 523A)
. . . . CalifVRDL107_2009_11_15 (
. . . . . . . . . . . . 35I [H5N1],
. . . . . . . . . . . . 39N,
. . . . . . . . . . . . syn152I,
. . . . . . . . . . . . syn219I,
. . . . . . . . . . . . syn276H [1918, S5],
. . . . . . . . . . . . syn456L [H5N1],
. . . . . . . . . . . . 463V,
. . . . . . . . . . . . 523A)
. . . . KoreaAF2376_2009_10_27 (
. . . . . . . . 88P [H2N3, H5N1, H11],
. . . . . . . . . . . . [Victoria508_2010_07_24 with ext changes,
. . . . . . . . . . . HunanHechengSWL1616_2009-11-23,
. . . . . . . . . . . Nevada15_9F_2009_09_10,
. . . . . . . . . . . GermanyCologne13_2009_06_29],
. . . . . . . . 131P,
. . . . . . . . 280A,
. . . . . . . . 290K [HunanHechengSWL1617_2009_11_23],
. . . . . . . . HA truncated after aa386)
. . . . Nevada15_9F_2009_09_10 (
. . . . . . . . 22I,
. . . . . . . . 88P,
. . . . . . . . 225E,
. . . . . . . . 256F,
. . . . . . . . 299Y,
. . . . . . . . 300S,
. . . . . . . . syn384S)
. . . . GermanyCologne13_2009_06_29 (
. . . . . . . . HA truncated until aa28,
. . . . . . . . 35I,
. . . . . . . . 38V,
. . . . . . . . 88P,
. . . . . . . . syn108L,
. . . . . . . . syn205G,
. . . . . . . . 206S,
. . . . . . . . syn276H,
. . . . . . . . HA truncated after aa321)
A nine year old female patient from Little River, Victoria, Australia was sampled by the Monash Medical Centre on 2010-07-24 during the current influenza epidemic. That sequence, OzVictoria508_9F_2010_07_24, is one of only six in this deposit without an antigenic characterisation. The HA gene segment carries 14 polymorphisms.
Significant homology exists with H5N1 and H7N7. Changes at amino acid position 238 and the region are associated with the 230I polymorphism. With the numerous polymorphisms and the lack of antigenic testing, this sequence is suggestive of immune escape tendencies.
The continual building of changes onto the pandemic H1N1 background requires ongoing surveillance. Genetic data continues to ebb from Asia, India and Oceania into Fall European and North American sequences. India is represented in the conforming predecessor polymorphism list for this Australian sequence. Finding similar genetic quality in the near future is a reasonable expectation for the upcoming North American epidemic.
. . . . OzVictoria508_9F_2010_07_24 (
. . . . . . . . 35I [H5N1],
. . . . . . . . 88P [H2N3, H5N1, H11],
. . . . . . . . . . . [HunanHechengSWL1616_2009-11-23,
. . . . . . . . . . . KoreaAF2376_2009_10_27
. . . . . . . . . . . . . . . with 280A and 290K
. . . . . . . . . . . Nevada15_9F_2009_09_10
. . . . . . . . . . . . . . . with 22I, 225E, 256F, 299Y,
. . . . . . . . . . . . . . . . . . 299Y, 300S, syn384S,
. . . . . . . . . . . GermanyCologne13_2009_06_29
. . . . . . . . . . . . . . . with 35I, 38V, syn108L,
. . . . . . . . . . . . . . . . . . syn205G, 206s, syn276H],
. . . . . . . . syn102E [SingON2407_2009_12_13,
. . . . . . . . . . . . . . . Singapore544_2009_12_10,
. . . . . . . . . . . . . . . Brussels243_2009_11_09
. . . . . . . . . . . . . . . . . . . . with syn44L and 89G],
. . . . . . . . syn152I [CalifVRDL115_2009_12_04,
. . . . . . . . . . . . . . . NY6939_2009_12_11,
. . . . . . . . . . . . . . . tkOntarioFAV117_1C_2009_12_07
. . . . . . . . . . . . . . . . . . . . with 35I, syn219I, syn276H,
. . . . . . . . . . . . . . . . . . . . . . . syn456L, 463V, 523A,
. . . . . . . . . . . . . . . England1050_2009_12,
. . . . . . . . . . . . . . . Scotland103_2009_12,
. . . . . . . . . . . . . . . England1051_2009_12,
. . . . . . . . . . . . . . . ItalyAncona451_2009_11_27_f,
. . . . . . . . . . . . . . . NY6607_2009_11_24,
. . . . . . . . . . . . . . . CalifVRDL107_2009_11_15,
. . . . . . . . . . . . . . . CalifVRDL101_2009_11_05,
. . . . . . . . . . . . . . . DC_114_2009_11_04,
. . . . . . . . . . . . . . . England94800096_2009_11,
. . . . . . . . . . . . . . . Calif_SD35_2009_10_26,
. . . . . . . . . . . . . . . NY5447_2009_10_23,
. . . . . . . . . . . . . . . CalifVRDL84_2009_10_09,
. . . . . . . . . . . . . . . CalifVRDL87_2009_10_09,
. . . . . . . . . . . . . . . IndiaPune6196_2009_08,
. . . . . . . . . . . . . . . IndiaDhule9433_2009_08,
. . . . . . . . . . . . . . . SantoDomingoWR1057N_2009_07_02,
. . . . . . . . . . . . . . . SantoDomingoWR1058N_2009_07_02,
. . . . . . . . . . . . . . . SantoDomingoWR1059N_2009_06_30],
. . . . . . . . 206S,
. . . . . . . . syn219I [CalifVRDL115_2009_12_04
. . . . . . . . . . . . . . . . . with 35I, syn152I, syn276H,
. . . . . . . . . . . . . . . . . . . . syn456L, 463V, 523A,
. . . . . . . . . . . . . . FL_Pen213_2009_11_17
. . . . . . . . . . . . . . . . . . . . with 35I, syn152I, 273A,
. . . . . . . . . . . . . . . . . . . . syn456L, 463V, 523A,
. . . . . . . . . . . . . . CalifVRDL107_2009_11_15
. . . . . . . . . . . . . . . . . . . . with 35I, syn152I, syn276H,
. . . . . . . . . . . . . . . . . . . . syn456L, 463V, 523A,
. . . . . . . . 238D (GAc) [H2N3, H7N3, H7N7],
. . . . . . . . . . . . . . . . . . [Belgorod2_2010-03-15 (GAt),
. . . . . . . . . . . . . . . . . . Kaliningrad01_2009_11_02 (GAt)
. . . . . . . . . . . . . . . . . . . . . . . . with 225E and 226R,
. . . . . . . . . . . . . . . . . . AthensINS398_2010-01-24 GAt),
. . . . . . . . . . . . . . . . . . KaliningradCRIE_DA_2009-09-26 (GAt),
. . . . . . . . . . . . . . . . . . KaliningradCRIE_KG_2009-09-25 (GAt),
. . . . . . . . . . . . . . . . . . KaliningradCRIE_MA_2009-09-25 (GAt),
. . . . . . . . . . . . . . . . . . KaliningradCRIE_SHD_2009-09-25 (GAt),
. . . . . . . . . . . . . . . . . . KaliningradCRIE_ZD_2009-09-25 (GAt)],
. . . . . . . . syn247A [Belize8756_2009_10_08,
. . . . . . . . . . . . . . . Singapore93_2009_06_22]
. . . . . . . . syn254P,
. . . . . . . . 272G [Niigata19_2009_12_31,
. . . . . . . . . . . . GuangdongSWL36_2009_11_29],
. . . . . . . . syn276H [1918, S5],
. . . . . . . . syn388K [H5N1],
. . . . . . . . . . . . . . . [NagasakiHA_10_28_2010_03_23
. . . . . . . . . . . . . . . . . . . . . with 22I,
. . . . . . . . . . . . . . . NagasakiHA_10_26_2010_03_15
. . . . . . . . . . . . . . . . . . . . . with 22I, syn103E,
. . . . . . . . . . . . . . . NagasakiHA_10_24_2010_03_08
. . . . . . . . . . . . . . . . . . . . . with syn103E,
. . . . . . . . . . . . . . . GuangxiLonganSWL1990_2010_02_08
. . . . . . . . . . . . . . . . . . . . . with 453K, syn462E,
. . . . . . . . . . . . . . . JiangxiDonghuSWL15_2010_01_04
. . . . . . . . . . . . . . . . . . . . . with syn106E, 149R, syn456L (TTg),
. . . . . . . . . . . . . . . ViennaINS142_2009_11_26
. . . . . . . . . . . . . . . . . . . . . with syn97D, 99T,
. . . . . . . . . . . . . . . CzechUsti208_2009_11_25
. . . . . . . . . . . . . . . . . . . . . with 268T,
. . . . . . . . . . . . . . . GhanaFS_1921_2009_11_11,
. . . . . . . . . . . . . . . Alaska44_2009_11_17
. . . . . . . . . . . . . . . . . . . . . with syn275V, 276N,
. . . . . . . . . . . . . . . CalifVRDL76_2009_09_21
. . . . . . . . . . . . . . . . . . . . . with syn283Q,
. . . . . . . . . . . . . . . Taiwan206_2009_09_18,
. . . . . . . . . . . . . . . Taiwan177_2009_09_18,
. . . . . . . . . . . . . . . Taiwan167_2009_09_18,
. . . . . . . . . . . . . . . Taiwan156_2009_09_18,
. . . . . . . . . . . . . . . Taiwan143_2009_09_15
. . . . . . . . . . . . . . . . . . . . . with 205E mix,
. . . . . . . . . . . . . . . Utah20_C2_2_2009_07_25_VxX
. . . . . . . . . . . . . . . . . . . . . with 159D, 206S, 227G
. . . . . . . . . . . . . . . Slovenia2687_2009_07_01
. . . . . . . . . . . . . . . . . . . . . with 35I, 206S],
. . . . . . . . syn456L [H5N1],
. . . . . . . . 463V,
. . . . . . . . 523A [Nebraska02_2010_03_11,
. . . . . . . . . . . . NagasakiHA1022_2010_03_01_syn413K,
. . . . . . . . . . . . DomRepublic3768_2009_12_15,
. . . . . . . . . . . . NY6939_2009_12_11,
. . . . . . . . . . . . CalifVRDL115_2009_12_04,
. . . . . . . . . . . . NY6607_2009_11_24,
. . . . . . . . . . . . RheinlandPfalz81_2009_11_23,
. . . . . . . . . . . . Berlin210_2009_11_16,
. . . . . . . . . . . . BadenWurttemberg511_2009_11_16,
. . . . . . . . . . . . CalifVRDL107_2009_11_15,
. . . . . . . . . . . . FL_Pensacola40_2009_11_09,
. . . . . . . . . . . . CalifVRDL101_2009_11_05,
. . . . . . . . . . . . DC114_2009_11_04,
. . . . . . . . . . . . Calif_SD35_2009_10_26,
. . . . . . . . . . . . NY5447_2009_10_23,
. . . . . . . . . . . . CalifVRDL84_2009_10_09,
. . . . . . . . . . . . CalifVRDL87_2009_10_09,
. . . . . . . . . . . . KuwaitN13013_2009_08_31_syn413K])
Supporting Sequences
. . . . CalifVRDL115_2009_12_04 (
. . . . . . . . . . . . 35I [H5N1],
. . . . . . . . . . . . 77N,
. . . . . . . . . . . . syn152I,
. . . . . . . . . . . . syn219I,
. . . . . . . . . . . . syn276H [1918, S5],
. . . . . . . . . . . . syn456L [H5N1],
. . . . . . . . . . . . 463V,
. . . . . . . . . . . . 523A)
. . . . FL_Pen213_2009_11_17 (
. . . . . . . . . . . . 35I [H5N1],
. . . . . . . . . . . . syn152I,
. . . . . . . . . . . . syn219I,
. . . . . . . . . . . . 273A,
. . . . . . . . . . . . syn276H [1918, S5],
. . . . . . . . . . . . syn456L [H5N1],
. . . . . . . . . . . . 463V,
. . . . . . . . . . . . 523A)
. . . . CalifVRDL107_2009_11_15 (
. . . . . . . . . . . . 35I [H5N1],
. . . . . . . . . . . . 39N,
. . . . . . . . . . . . syn152I,
. . . . . . . . . . . . syn219I,
. . . . . . . . . . . . syn276H [1918, S5],
. . . . . . . . . . . . syn456L [H5N1],
. . . . . . . . . . . . 463V,
. . . . . . . . . . . . 523A)
. . . . KoreaAF2376_2009_10_27 (
. . . . . . . . 88P [H2N3, H5N1, H11],
. . . . . . . . . . . . [Victoria508_2010_07_24 with ext changes,
. . . . . . . . . . . HunanHechengSWL1616_2009-11-23,
. . . . . . . . . . . Nevada15_9F_2009_09_10,
. . . . . . . . . . . GermanyCologne13_2009_06_29],
. . . . . . . . 131P,
. . . . . . . . 280A,
. . . . . . . . 290K [HunanHechengSWL1617_2009_11_23],
. . . . . . . . HA truncated after aa386)
. . . . Nevada15_9F_2009_09_10 (
. . . . . . . . 22I,
. . . . . . . . 88P,
. . . . . . . . 225E,
. . . . . . . . 256F,
. . . . . . . . 299Y,
. . . . . . . . 300S,
. . . . . . . . syn384S)
. . . . GermanyCologne13_2009_06_29 (
. . . . . . . . HA truncated until aa28,
. . . . . . . . 35I,
. . . . . . . . 38V,
. . . . . . . . 88P,
. . . . . . . . syn108L,
. . . . . . . . syn205G,
. . . . . . . . 206S,
. . . . . . . . syn276H,
. . . . . . . . HA truncated after aa321)
2010-08-31
HA 230I RBS Polymorphism Potential for Europe
Current trending indicates a reportable potential for the M230I polymorphism spreading on the Hemagglutinin of PF11. This Receptor Binding Domain change may enhance Vaccine Escape from the currently selected vaccine target candidate, CA/07 X181.
For those who are following the prediction on February 25, 2010, the pandemic reservoir now shows multiple instances of multiple encodings for 230I. Model adjustment and data transparency allowed a second set of detailed geographic predictions on 2010-08-09 that have also found traction.
The 230I bearing sequences meeting the prediction are documented in the detailed discussion on Vaccine Escape that demonstrates a 100% change rate in the pandemic influenza (pH1N1) reservoir at the critical HA genetics range between amino acid positions 186 and 248. 89% of the amino acid positions have notated revisions.
Expectations for the M230I polymorphism, that first came to our notice for zoonotic concern on the H5N1 human fatality cluster, have now been revised based on the most current public data. The GeneWurx model approximates that HA 230I will appear in the PF11 RBS according to the following geographic probabilities.
An accelerated viral self-revision, subsequently moving toward M230I, may be modulated by the substantially higher rates of host exposure in the lower age brackets. Additionally, that group’s multiplicity of exposure to a wider variation of influenza strains may factor into the host response/viral revision equation. In plain terms, the viral reservoir is being forced toward hard labour in order to infect and re-infect the youth.
Just as hard work builds muscle, viral exertion against a complex host response challenges the reservoir subset to revise toward an optimal solution. 230I is an excellent and proven tertiary response for a virus on this type of offensive.
These probabilities will be updated as additional data is made public. Transparency at this post-pandemic stage is essential to formulate viable responses for the risk groups. Release of sequences and clinical data of a finer detail and higher quantity will allow information-based decisions.
For those who are following the prediction on February 25, 2010, the pandemic reservoir now shows multiple instances of multiple encodings for 230I. Model adjustment and data transparency allowed a second set of detailed geographic predictions on 2010-08-09 that have also found traction.
The 230I bearing sequences meeting the prediction are documented in the detailed discussion on Vaccine Escape that demonstrates a 100% change rate in the pandemic influenza (pH1N1) reservoir at the critical HA genetics range between amino acid positions 186 and 248. 89% of the amino acid positions have notated revisions.
Expectations for the M230I polymorphism, that first came to our notice for zoonotic concern on the H5N1 human fatality cluster, have now been revised based on the most current public data. The GeneWurx model approximates that HA 230I will appear in the PF11 RBS according to the following geographic probabilities.
- 75% probability in Germany sampled by 2010-12-01.
- 75% probability in Spain sampled by 2010-12-01.
- 85% probability sampled by 2010-12-01 in one of:
- Denmark
- Norway
- Sweden
- 5% or less probability of HA 230I within 60 days of conserving across PF11.
- 7% probability of HA 230I within 180 days of conserving on one or more Hydrae.
An accelerated viral self-revision, subsequently moving toward M230I, may be modulated by the substantially higher rates of host exposure in the lower age brackets. Additionally, that group’s multiplicity of exposure to a wider variation of influenza strains may factor into the host response/viral revision equation. In plain terms, the viral reservoir is being forced toward hard labour in order to infect and re-infect the youth.
Just as hard work builds muscle, viral exertion against a complex host response challenges the reservoir subset to revise toward an optimal solution. 230I is an excellent and proven tertiary response for a virus on this type of offensive.
These probabilities will be updated as additional data is made public. Transparency at this post-pandemic stage is essential to formulate viable responses for the risk groups. Release of sequences and clinical data of a finer detail and higher quantity will allow information-based decisions.
2010-08-27
HA 230I Documented in Texas with 225E RBD Revision
The United States Air Force School of Aerospace Medicine published a sequence on 2010-08-20 with multiple RBD changes sampled on 2009-10-04 from an 18 year old male in Texas. This TexasAF2579_2009_10_04 sequence meets the geographic criteria and genetic change prediction published on 2010-08-09. The HA 230I in this case is combined with a second RBD polymorphism, 225E.
. . . . TexasAF2579_2009_10_04 (
. . . . . . . . syn20D,
. . . . . . . . 225E,
. . . . . . . . 230I (ATa),
. . . . . . . . syn246E [Texas77_E3_2009_10_06],
. . . . . . . . 264D,
. . . . . . . . 300S,
. . . . . . . . HA truncated after aa386)
Supporting Sequences
. . . . Texas77_E3_2009_10_06 (
. . . . . . . . 159S,
. . . . . . . . syn173G,
. . . . . . . . 219V,
. . . . . . . . 226R,
. . . . . . . . syn246E,
. . . . . . . . 275A,
. . . . . . . . 377K [H9N2])
. . . . TexasAF2589_2009_10_04 (
. . . . . . . . 159S,
. . . . . . . . syn173G,
. . . . . . . . 275A,
. . . . . . . . 377K [H9N2],
. . . . . . . . HA truncated after aa386)
. . . . TexasAF2627_2009_12_20 (
. . . . . . . . syn177L [H3N8, H6, H7N7],
. . . . . . . . . . . . . . [NagasakiHA_10_30_2010_03_29 with 513V, 550K,
. . . . . . . . . . . . . . NagasakiHA_10_27_2010_03_15 with 513V, 550K,
. . . . . . . . . . . . . . NY3230_2010_01_25 with syn213F,
. . . . . . . . . . . . . . Kansas25_2009_12_07 with 50A,
. . . . . . . . . . . . . . Indiana21_2009_12_01 with 212E, 313K,
. . . . . . . . . . . . . . SwedenGothenburg2_2009_12_01_xL with 146G,
. . . . . . . . . . . . . . Tambov_LLA_2009_11_30_xL_f with 225G,
. . . . . . . . . . . . . . Perm01_2009_11_25_xL_f,
. . . . . . . . . . . . . . MoscowOb_ZNF_2009_11_24_xL_f,
. . . . . . . . . . . . . . Ivanovo_KOE_2009_11_25_xL_f,
. . . . . . . . . . . . . . Astrakhan_CHRM_2009_11_24_xL_f,
. . . . . . . . . . . . . . GreeceThessaloniki2812_2009_11_22,
. . . . . . . . . . . . . . Ivanovo_STV1_2009_11_21 with 225G,
. . . . . . . . . . . . . . NorwayOslo110_2009_11_10,
. . . . . . . . . . . . . . MoscowOb_STV_2009_11_09_f with 225N,
. . . . . . . . . . . . . . GermanyNiedersachsen352_2009_11_05,
. . . . . . . . . . . . . . MoscowOb_OAM_2009_11_02_xL_f with 225G,
. . . . . . . . . . . . . . MoscowOb_DEI_2009_11_xL_f with 225G,
. . . . . . . . . . . . . . Ivanovo_AMV_2009_11_xL_f with 225G,
. . . . . . . . . . . . . . BelgiumBrussels106_2009_10_29,
. . . . . . . . . . . . . . Moscow_BVA_2009_10_24_xL_f with 225G,
. . . . . . . . . . . . . . SwedenUmea8_2009_10_07 with 0I, 244I,
. . . . . . . . . . . . . . Norway3364_2_2009_09_08_xL,
. . . . . . . . . . . . . . DenmarkAarhus82_2009_xL,
. . . . . . . . . . . . . . Orenburg_VNV_2009_08_06_xL,
. . . . . . . . . . . . . . England2800004_2009_07,
. . . . . . . . . . . . . . WiscD0008_2009_06_04],
. . . . . . . . 275A,
. . . . . . . . HA truncated after aa386)
. . . . TexasAF2579_2009_10_04 (
. . . . . . . . syn20D,
. . . . . . . . 225E,
. . . . . . . . 230I (ATa),
. . . . . . . . syn246E [Texas77_E3_2009_10_06],
. . . . . . . . 264D,
. . . . . . . . 300S,
. . . . . . . . HA truncated after aa386)
Supporting Sequences
. . . . Texas77_E3_2009_10_06 (
. . . . . . . . 159S,
. . . . . . . . syn173G,
. . . . . . . . 219V,
. . . . . . . . 226R,
. . . . . . . . syn246E,
. . . . . . . . 275A,
. . . . . . . . 377K [H9N2])
. . . . TexasAF2589_2009_10_04 (
. . . . . . . . 159S,
. . . . . . . . syn173G,
. . . . . . . . 275A,
. . . . . . . . 377K [H9N2],
. . . . . . . . HA truncated after aa386)
. . . . TexasAF2627_2009_12_20 (
. . . . . . . . syn177L [H3N8, H6, H7N7],
. . . . . . . . . . . . . . [NagasakiHA_10_30_2010_03_29 with 513V, 550K,
. . . . . . . . . . . . . . NagasakiHA_10_27_2010_03_15 with 513V, 550K,
. . . . . . . . . . . . . . NY3230_2010_01_25 with syn213F,
. . . . . . . . . . . . . . Kansas25_2009_12_07 with 50A,
. . . . . . . . . . . . . . Indiana21_2009_12_01 with 212E, 313K,
. . . . . . . . . . . . . . SwedenGothenburg2_2009_12_01_xL with 146G,
. . . . . . . . . . . . . . Tambov_LLA_2009_11_30_xL_f with 225G,
. . . . . . . . . . . . . . Perm01_2009_11_25_xL_f,
. . . . . . . . . . . . . . MoscowOb_ZNF_2009_11_24_xL_f,
. . . . . . . . . . . . . . Ivanovo_KOE_2009_11_25_xL_f,
. . . . . . . . . . . . . . Astrakhan_CHRM_2009_11_24_xL_f,
. . . . . . . . . . . . . . GreeceThessaloniki2812_2009_11_22,
. . . . . . . . . . . . . . Ivanovo_STV1_2009_11_21 with 225G,
. . . . . . . . . . . . . . NorwayOslo110_2009_11_10,
. . . . . . . . . . . . . . MoscowOb_STV_2009_11_09_f with 225N,
. . . . . . . . . . . . . . GermanyNiedersachsen352_2009_11_05,
. . . . . . . . . . . . . . MoscowOb_OAM_2009_11_02_xL_f with 225G,
. . . . . . . . . . . . . . MoscowOb_DEI_2009_11_xL_f with 225G,
. . . . . . . . . . . . . . Ivanovo_AMV_2009_11_xL_f with 225G,
. . . . . . . . . . . . . . BelgiumBrussels106_2009_10_29,
. . . . . . . . . . . . . . Moscow_BVA_2009_10_24_xL_f with 225G,
. . . . . . . . . . . . . . SwedenUmea8_2009_10_07 with 0I, 244I,
. . . . . . . . . . . . . . Norway3364_2_2009_09_08_xL,
. . . . . . . . . . . . . . DenmarkAarhus82_2009_xL,
. . . . . . . . . . . . . . Orenburg_VNV_2009_08_06_xL,
. . . . . . . . . . . . . . England2800004_2009_07,
. . . . . . . . . . . . . . WiscD0008_2009_06_04],
. . . . . . . . 275A,
. . . . . . . . HA truncated after aa386)
2010-08-14
Pune India Communicates Pandemic Genetic CrossTalk with England and United States
The practice of science exists to serve mankind by discovering answers.
Utilising advanced tools, accurate observations and absolute logic, the mysterious becomes discernable and the discernable, in turn, becomes actionable. Find a problem. Fix a problem.
Tonight, we ask science to take a cue from a bouncing red ball, a small red ball. Focus and faculty are requested. We will paint a blue 50V on one small, red bouncing ball and then see where it goes. If the results are plausible, we may try another.
Follow that springy, red ball from one continent to the next. And then back again.
The ΣPF11 influenza reservoir is not mysterious in the least when the data that has been collected is actually made available for evaluation. Even post-pandemic publications may be informative. We come to some such encounter today from a recent post-pandemic deposit of pandemic H1N1 sequences from England.
Watch the RnR * polymorphisms choose backgrounds and associate with other revisions as this Enhanced Acquisition virus becomes something new everyday in every city around the globe. Humans, swine and birds are vectors, but only humans and birds can fly. Swine store; humans and birds promote.
Let the following sequences describe the arc of two individual silent changes between and among India, the United Kingdom and the United States of America, including military personnel. Synonymous 50V and synonymous 348V are only two examples. These two representatives are certainly not comprehensive of this interchange behaviour.
. . . . England94840759_2009_11 (
. . . . . . . . syn50V [GDWujiang51_2010_03_18,
. . . . . . . . . . . . . . SouthCarolina02E3_2010_03_05
. . . . . . . . . . . . . . . . . . . . . . with 25R,
. . . . . . . . . . . . . . TexasJMS413_2010_02_03
. . . . . . . . . . . . . . . . . . . . . . with 25R,
. . . . . . . . . . . . . . TexasJMS391_2009_12_23
. . . . . . . . . . . . . . . . . . . . . . with 25R,
. . . . . . . . . . . . . . IndiaPune10604_2009_09],
. . . . . . . . 214R,
. . . . . . . . syn428L)
. . . . England734_2009_10 (
. . . . . . . . syn50V [GDWujiang51_2010_03_18,
. . . . . . . . . . . . . . SouthCarolina02E3_2010_03_05
. . . . . . . . . . . . . . . . . . . . . . with 25R,
. . . . . . . . . . . . . . TexasJMS413_2010_02_03
. . . . . . . . . . . . . . . . . . . . . . with 25R,
. . . . . . . . . . . . . . TexasJMS391_2009_12_23
. . . . . . . . . . . . . . . . . . . . . . with 25R,
. . . . . . . . . . . . . . IndiaPune10604_2009_09])
. . . . Eng662_2009_08 (
. . . . . . . . 25R [SouthCarolina02E3_2010_03_05
. . . . . . . . . . . . . . . .. . . . with syn50V,
. . . . . . . . . . . TexasJMS413_2010_02_03
. . . . . . . . . . . . . . . .. . . . with syn50V,
. . . . . . . . . . . TexasJMS391_2009_12_23
. . . . . . . . . . . . . . . .. . . . with syn50V,
. . . . . . . . . . . Texas extensive (10 more),
. . . . . . . . . . . Afghanistan (2),
. . . . . . . . . . . Russia149_2009_11_01_xL,
. . . . . . . . . . . Utah42_2009_07_24
. . . . . . . . . . . . . . . with 225G / 225N],
. . . . . . . . syn116R [NY6530_2010_02_21,
. . . . . . . . . . . . . . swOsaka1_2009_10,
. . . . . . . . . . . . . . Texas45071344_2009_09_07,
. . . . . . . . . . . . . . Portugal (2) 2009_08_19,
. . . . . . . . . . . . . . Military (30) 2009_08 to 2009_12,
. . . . . . . . . . . . . . Australia as early as 2009_07 (3),
. . . . . . . . . . . . . . SingTLL53_2009_06_14,
. . . . . . . . . . . . . . Columbia 2009_06 (2),
. . . . . . . . . . . . . . WiscD1606_2009_05_03],
. . . . . . . . syn348V [JapanAF2284_2009_11_27,
. . . . . . . . . . . . . . Frankfurt301_2009_11_23,
. . . . . . . . . . . . . . Ankara27_2009_11_11,
. . . . . . . . . . . . . . Yaroslavl_CHMV_2009_11_10_f with 225G,
. . . . . . . . . . . . . . Yakutsk_EAV_2009_11_18,
. . . . . . . . . . . . . . Thailand (24) as late as 2009_09_25,
. . . . . . . . . . . . . . BZ_SaoPaulo53823_2009_08_01_f,
. . . . . . . . . . . . . . Yakutsk_EAV_2009_11_18,
. . . . . . . . . . . . . . IndiaPune6196_2009_08,
. . . . . . . . . . . . . . IndiaDhule9433_2009_08,
. . . . . . . . . . . . . . IndiaPune807_2009_07,
. . . . . . . . . . . . . . PNG_PortMoresby2005_2009_07_08,
. . . . . . . . . . . . . . MoroccoRabat72_2009_07_02,
. . . . . . . . . . . . . . Slovenia2322_2009_07_01,
. . . . . . . . . . . . . . SingON442_2009_06_25,
. . . . . . . . . . . . . . ThailandCUB5_2009_06_13],
. . . . . . . . 494K [Indiana21_2009_12_10,
. . . . . . . . . . . . NewMexico07_2009_10_18,
. . . . . . . . . . . . NY5755_2009_10_01,
. . . . . . . . . . . . Ankara12_2009_09,
. . . . . . . . . . . . Ankara16_2009_09,
. . . . . . . . . . . . Ankara29_2009,
. . . . . . . . . . . . NY4568_2009_07_09,
. . . . . . . . . . . . NY4500_2009_07_01,
. . . . . . . . . . . . RhodeIsland04_2009_06_01])
Three American sequences are on file from December 2009 to March 2010 that accumulate both the 25R of Eng662_2009_08 and the syn50V of IndiaPune10604_2009_09. A pattern of attraction or permissiveness is suggested.
India is in the grip of a post-pandemic acceleration of death due to burgeoning caseloads and an apparent change in viral behaviour. They have experience, foresight, materials and initiative, but the disease is overcoming the system and killing the citizens. The health purveyors are doing everything by the book, but the chapters are out-dated apparently.
What will we find in those sequences? How may we adapt our methods and materials to assist the families in India? When will those viral changes be adopted in other countries?
Pondering is excellent, but action is better.
The sequences will tell the truth and provide a footing to act. Please publish the sequences from May to August 2010.
Supporting / Related Sequences
. . . . India3725_2010_04_03 (
. . . . . . . . 117T,
. . . . . . . . syn167S,
. . . . . . . . 186P,
. . . . . . . . syn474C,
. . . . . . . . syn526S [SwedenMalmoe2_2010_05_07])
. . . . IndiaPune10604_2009_09 (
. . . . . . . . syn2N [UkrSumy797_2009_11_13_f,
. . . . . . . . . . . . . MongoliaJP5756_2009_10_15,
. . . . . . . .. . . . . SingON2416_2009_12_15],
. . . . . . . . syn50V [TexasJMS391_2009_12_23,
. . . . . . . . . . . . . . TexasJMS413_2009_02_03,
. . . . . . . . . . . . . . SouthCarolina02E3_2010_03_05],
. . . . . . . . syn178V (GTt) [NewHampshire02E3_2010_02_19 (GTa)],
. . . . . . . . 206S,
. . . . . . . . 296H,
. . . . . . . . syn348V [Yaroslavl_CHMV_2009_11_10_f with 225G,
. . . . . . . . . . . . . . Yakutsk_EAV_2009_11_18,
. . . . . . . . . . . . . . BZ_SaoPaulo53823_2009_08_01_f,
. . . . . . . . . . . . . . Eng662_2009_08],
. . . . . . . . syn485G [Nebraska 01_2010_01_28,
. . . . . . . . . . . . . . Orenburg2974_2009_11_16_xL,
. . . . . . . . . . . . . . NagasakiHA10_22_2010_03_01])
. . . . IndiaPune6196_2009_08 (
. . . . . . . . #12E,
. . . . . . . . syn2N [UkrSumy797_2009_11_13_f,
. . . . . . . . . . . . . MongoliaJP5756_2009_10_15,
. . . . . . . .. . . . . SingON2416_2009_12_15],
. . . . . . . . syn152I [NY6939_2009_12_11,
. . . . . . . . . . . . . . . tkOntarioFAV117_1C_2009_12_07,
. . . . . . . . . . . . . . . CalifVRDL115_2009_12_04,
. . . . . . . . . . . . . . . England1051_2009_12,
. . . . . . . . . . . . . . . England1050_2009_12,
. . . . . . . . . . . . . . . Scotland103_2009_12,
. . . . . . . . . . . . . . . England94800096_2009_11,
. . . . . . . . . . . . . . . ItalyAncona451_2009_11_27_f,
. . . . . . . . . . . . . . . NY6607_2009_11_24,
. . . . . . . . . . . . . . . CalifVRDL107_2009_11_15,
. . . . . . . . . . . . . . . CalifVRDL101_2009_11_05,
. . . . . . . . . . . . . . . DC_114_2009_11_04,
. . . . . . . . . . . . . . . Calif_SD35_2009_10_26,
. . . . . . . . . . . . . . . NY5447_2009_10_23,
. . . . . . . . . . . . . . . CalifVRDL84_2009_10_09,
. . . . . . . . . . . . . . . CalifVRDL87_2009_10_09,
. . . . . . . . . . . . . . . IndiaDhule9433_2009_08,
. . . . . . . . . . . . . . . SantoDomingoWR1057N_2009_07_02,
. . . . . . . . . . . . . . . SantoDomingoWR1058N_2009_07_02,
. . . . . . . . . . . . . . . SantoDomingoWR1059N_2009_06_30],
. . . . . . . . 206S,
. . . . . . . . 296H,
. . . . . . . . syn300P (CCt) [H5N1, H6N1, H7N3, H7N7],
. . . . . . . . . . . . . . . . . [Virginia24_2009_06_03 (CCt),
. . . . . . . . . . . . . . . . . NY0352_2009_12_27 (CCt),
. . . . . . . . . . . . . . . . . IllinoisAF2223_2009_12_18 (CCt),
. . . . . . . . . . . . . . . . . SingON2416_2009_12_15 (CCa),
. . . . . . . . . . . . . . . . . Vietnam2043_2009_12_01_TmX (CCa),
. . . . . . . . . . . . . . . . . HunanFur129_2010_01_13 (CCa),
. . . . . . . . . . . . . . . . . Slovenia5613_2009_12 (CCa),
. . . . . . . . . . . . . . . . . Minnesota40_2009_11_19 (CCa) w syn252V],
. . . . . . . . 342R,
. . . . . . . . syn348V [Yaroslavl_CHMV_2009_11_10_f with 225G,
. . . . . . . . . . . . . . Yakutsk_EAV_2009_11_18,
. . . . . . . . . . . . . . BZ_SaoPaulo53823_2009_08_01_f,
. . . . . . . . . . . . . . Eng662_2009_08],
. . . . . . . . syn355H [H2, H5N1, H6N1],
. . . . . . . . . . . . . . [GDLiwan1170_2010_03_14,
. . . . . . . . . . . . . . NY2963_2010_01_22
. . . . . . . . . . . . . .. . . . . . . . with 50E, 100N,
. . . . . . . . . . . . . . ItalyAncona508_2009_12_31
. . . . . . . . . . . . . .. . . . . . . . with syn181G,
. . . . . . . . . . . . . . Yamagata803_2009_12_21,
. . . . . . . . . . . . . . Astrakhan_CHRM_2009_11_24_xL_f,
. . . . . . . . . . . . . . MoscowOb_ZNF_2009_11_24_xL_f,
. . . . . . . . . . . . . . Ivanovo_STV1_2009_11_21
. . . . . . . . . . . . . .. . . . . . . . with 225G,
. . . . . . . . . . . . . . FloridaPensacola107_2009_11_12,
. . . . . . . . . . . . . . MoscowOb_STV_2009_11_09_f
. . . . . . . . . . . . . .. . . . . . . . with 225N,
. . . . . . . . . . . . . . swTaiwanTD4119B2_2009_11_04,
. . . . . . . . . . . . . . ArgentinaHNRG44_2009_06_30
. . . . . . . . . . . . . .. . . . . . . . with 71G,
. . . . . . . . . . . . . . ArgentinaHNRG39_2009_06_23
. . . . . . . . . . . . . .. . . . . . . . with 259T,
. . . . . . . . . . . . . . WiscD0589_2009_06_03
. . . . . . . . . . . . . .. . . . . . . . with syn178V])
. . . . IndiaDhule9433_2009_08 (
. . . . . . . . #12E,
. . . . . . . . syn2N [UkrSumy797_2009_11_13_f,
. . . . . . . . . . . . . MongoliaJP5756_2009_10_15,
. . . . . . . . . . . . . SingON2416_2009_12_15,
. . . . . . . . . . . . . IndiaPune10604_2009_09, et al],
. . . . . . . . syn152I [NY6939_2009_12_11,
. . . . . . . . . . . . . . . tkOntarioFAV117_1C_2009_12_07,
. . . . . . . . . . . . . . . CalifVRDL115_2009_12_04,
. . . . . . . . . . . . . . . England1051_2009_12,
. . . . . . . . . . . . . . . England1050_2009_12,
. . . . . . . . . . . . . . . Scotland103_2009_12,
. . . . . . . . . . . . . . . England94800096_2009_11,
. . . . . . . . . . . . . . . ItalyAncona451_2009_11_27_f,
. . . . . . . . . . . . . . . NY6607_2009_11_24,
. . . . . . . . . . . . . . . CalifVRDL107_2009_11_15,
. . . . . . . . . . . . . . . CalifVRDL101_2009_11_05,
. . . . . . . . . . . . . . . DC_114_2009_11_04,
. . . . . . . . . . . . . . . Calif_SD35_2009_10_26,
. . . . . . . . . . . . . . . NY5447_2009_10_23,
. . . . . . . . . . . . . . . CalifVRDL84_2009_10_09,
. . . . . . . . . . . . . . . CalifVRDL87_2009_10_09,
. . . . . . . . . . . . . . . IndiaPune6196_2009_08,
. . . . . . . . . . . . . . . SantoDomingoWR1057N_2009_07_02,
. . . . . . . . . . . . . . . SantoDomingoWR1058N_2009_07_02,
. . . . . . . . . . . . . . . SantoDomingoWR1059N_2009_06_30],
. . . . . . . . 176I,
. . . . . . . . 205W,
. . . . . . . . 206S,
. . . . . . . . 252L (cTG) [Maryland03_2010_01_13 (tTG),
. . . . . . . . . . . . . . . Guangdong2361_2009_11_25 (tTG)],
. . . . . . . . 296H,
. . . . . . . . syn348V [Yaroslavl_CHMV_2009_11_10_f with 225G,
. . . . . . . . . . . . . . Yakutsk_EAV_2009_11_18,
. . . . . . . . . . . . . . BZ_SaoPaulo53823_2009_08_01_f,
. . . . . . . . . . . . . . Eng662_2009_08],
. . . . . . . . syn386I [1918, Unique to PF11])
. . . . IndiaPune807_2009_07 (
. . . . . . . . #12E,
. . . . . . . . syn2N [UkrSumy797_2009_11_13_f ,
. . . . . . . . . . . . . MongoliaJP5756_2009_10_15,
. . . . . . . .. . . . . SingON2416_2009_12_15],
. . . . . . . . 100Q [Unique to PF11],
. . . . . . . . syn104L [CalifVRDL132_2009_12_30,
. . . . . . . . . . . . . . . Texas45122538_2009_09_12,
. . . . . . . . . . . . . . . WiscD0410_2009_09_24,
. . . . . . . . . . . . . . . WiscD1355_2009_09_21],
. . . . . . . . 206S,
. . . . . . . . 296H,
. . . . . . . . syn348V [Yaroslavl_CHMV_2009_11_10_f with 225G,
. . . . . . . . . . . . . . Yakutsk_EAV_2009_11_18,
. . . . . . . . . . . . . . BZ_SaoPaulo53823_2009_08_01_f,
. . . . . . . . . . . . . . Eng662_2009_08],
. . . . . . . . 461E [Unique to PF11]),
. . . . England1048_2009_12 (
. . . . . . . . 214R,
. . . . . . . . 225E,
. . . . . . . . 324I)
. . . . England1051_2009_12 (
. . . . . . . . syn10Y,
. . . . . . . . 35I,
. . . . . . . . syn152I [NY6939_2009_12_11,
. . . . . . . . . . . . . . . tkOntarioFAV117_1C_2009_12_07,
. . . . . . . . . . . . . . . CalifVRDL115_2009_12_04,
. . . . . . . . . . . . . . . England1050_2009_12,
. . . . . . . . . . . . . . . Scotland103_2009_12,
. . . . . . . . . . . . . . . England94800096_2009_11,
. . . . . . . . . . . . . . . ItalyAncona451_2009_11_27_f,
. . . . . . . . . . . . . . . NY6607_2009_11_24,
. . . . . . . . . . . . . . . CalifVRDL107_2009_11_15,
. . . . . . . . . . . . . . . CalifVRDL101_2009_11_05,
. . . . . . . . . . . . . . . DC_114_2009_11_04,
. . . . . . . . . . . . . . . Calif_SD35_2009_10_26,
. . . . . . . . . . . . . . . NY5447_2009_10_23,
. . . . . . . . . . . . . . . CalifVRDL84_2009_10_09,
. . . . . . . . . . . . . . . CalifVRDL87_2009_10_09,
. . . . . . . . . . . . . . . IndiaPune6196_2009_08,
. . . . . . . . . . . . . . . IndiaDhule9433_2009_08,
. . . . . . . . . . . . . . . SantoDomingoWR1057N_2009_07_02,
. . . . . . . . . . . . . . . SantoDomingoWR1058N_2009_07_02,
. . . . . . . . . . . . . . . SantoDomingoWR1059N_2009_06_30],
. . . . . . . . 206S,
. . . . . . . . syn219I,
. . . . . . . . syn254P,
. . . . . . . . syn276H,
. . . . . . . . syn456L,
. . . . . . . . 463V,
. . . . . . . . 502K [Ukraine],
. . . . . . . . 523A)
. . . . SouthCarolina02E3_2010_03_05 (
. . . . . . . . 25R [Utah42_2009_07_24 with 225G / 225N,
. . . . . . . . . . . Texas extensive (12),
. . . . . . . . . . . Afghanistan (2),
. . . . . . . . . . . Russia149_2009_11_01_xL],
. . . . . . . . syn50V [TexasJMS391_2009_12_23,
. . . . . . . . . . . . . TexasJMS413_2009_02_03,
. . . . . . . . . . . . . IndiaPune10604_2009_09],
. . . . . . . . 130E (GAa) [1918],
. . . . . . . . . . . . [Netherlands2243_2009_11_17_xL (GAg) mix
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . with 158E, 225G,
. . . . . . . . . . . . Iraq8531_2009_09_08_xL (GAa) with 131L,
. . . . . . . . . . . . Guangdong0872_2009_12_27 (GAa),
. . . . . . . . . . . . SingTLL52_2009_06_14 (GAa),
. . . . . . . . . . . . swAlbertaOTH_33_23_2009_05_03 (GAa)],
. . . . . . . . 206T)
. . . . TexasJMS413_2010_02_03 (
. . . . . . . . 25R,
. . . . . . . . syn50V,
. . . . . . . . syn84E)
. . . . TexasJMS391_2009_12_23 (
. . . . . . . . 25R,
. . . . . . . . syn50V,
. . . . . . . . syn84E,
. . . . . . . . syn374A)
. . . . NY2963_2010_01_22 (
. . . . . . . . 50E,
. . . . . . . . 100N,
. . . . . . . . syn270I,
. . . . . . . . syn291T,
. . . . . . . . syn355H,
. . . . . . . . 377K)
. . . . FloridaPensacola107_2009_11_12 (
. . . . . . . . 35I,
. . . . . . . . syn338G,
. . . . . . . . syn355H,
. . . . . . . . syn456L)
. . . . WiscD0589_2009_06_03 (
. . . . . . . . syn36L,
. . . . . . . . syn178V,
. . . . . . . . 193N,
. . . . . . . . syn355H)
. . . . Indiana21_2009_12_01 (
. . . . . . . . syn12A,
. . . . . . . . syn177L,
. . . . . . . . syn193S,
. . . . . . . . 212E mix,
. . . . . . . . 313K,
. . . . . . . . syn346G,
. . . . . . . . 359G,
. . . . . . . . 377K,
. . . . . . . . 494K)
. . . . IllinoisAF2223_2009_12_18 (
. . . . . . . . syn34N,
. . . . . . . . syn300P (CCt),
. . . . . . . . 377K,
. . . . . . . . HA truncated after aa386)
. . . . CalifVRDL107_2009_11_15 (
. . . . . . . . 35I,
. . . . . . . . 39N,
. . . . . . . . syn152I,
. . . . . . . . 206S,
. . . . . . . . syn219I,
. . . . . . . . syn276H,
. . . . . . . . syn456L,
. . . . . . . . 463V,
. . . . . . . . 523A)
. . . . CalifVRDL115_2009_12_04 (
. . . . . . . . 35I,
. . . . . . . . 77N,
. . . . . . . . syn152I,
. . . . . . . . 206S,
. . . . . . . . syn219I,
. . . . . . . . syn276H,
. . . . . . . . syn456L,
. . . . . . . . 463V,
. . . . . . . . 523A)
. . . . Malmoe2_2010_05_07 (
. . . . . . . . 89G,
. . . . . . . . syn108L [tn],
. . . . . . . . syn159N,
. . . . . . . . 206T,
. . . . . . . . 259T [ArgentinaHNRG39_2009_06_23
. . . . . . . . . . . . . . . . . . . . with syn355H],
. . . . . . . . syn280T [1918, WSN33],
. . . . . . . . syn526S [India3725_2010_04_03])
. . . . ItalyAncona508_2009_12_31 (
. . . . . . . . syn172K,
. . . . . . . . syn181G,
. . . . . . . . syn239P,
. . . . . . . . syn355H,
. . . . . . . . 373H)
. . . . GDLiwan1170_2010_03_14 (
. . . . . . . . 131P,
. . . . . . . . 202A,
. . . . . . . . 271T,
. . . . . . . . 298V,
. . . . . . . . syn355H,
. . . . . . . . 375F)
. . . . tkOntarioFAV117_1C_2009_12_07 (
. . . . . . . . 35I [H5N1],
. . . . . . . . syn55L,
. . . . . . . . syn152I,
. . . . . . . . 186P,
. . . . . . . . syn205G,
. . . . . . . . syn219I,
. . . . . . . . syn276H [1918, S5],
. . . . . . . . syn456L,
. . . . . . . . 463V,
. . . . . . . . syn486T,
. . . . . . . . 523A)
Please refer to additional studies for further genetic analyses, including the survey on amino acid revisions potentially related to Vaccine Escape. A hyper-morphic, TamiFlu-resistant sequence from the state of Washington in Spring 2010 has recently been profiled with similar zoonotic influences.
This analysis was fueled by puneri amti and funded with contributions from concerned families, including HOD, BMS, MJV and CSB.
* Rare, not Random
Utilising advanced tools, accurate observations and absolute logic, the mysterious becomes discernable and the discernable, in turn, becomes actionable. Find a problem. Fix a problem.
Tonight, we ask science to take a cue from a bouncing red ball, a small red ball. Focus and faculty are requested. We will paint a blue 50V on one small, red bouncing ball and then see where it goes. If the results are plausible, we may try another.
Follow that springy, red ball from one continent to the next. And then back again.
The ΣPF11 influenza reservoir is not mysterious in the least when the data that has been collected is actually made available for evaluation. Even post-pandemic publications may be informative. We come to some such encounter today from a recent post-pandemic deposit of pandemic H1N1 sequences from England.
Watch the RnR * polymorphisms choose backgrounds and associate with other revisions as this Enhanced Acquisition virus becomes something new everyday in every city around the globe. Humans, swine and birds are vectors, but only humans and birds can fly. Swine store; humans and birds promote.
Let the following sequences describe the arc of two individual silent changes between and among India, the United Kingdom and the United States of America, including military personnel. Synonymous 50V and synonymous 348V are only two examples. These two representatives are certainly not comprehensive of this interchange behaviour.
. . . . England94840759_2009_11 (
. . . . . . . . syn50V [GDWujiang51_2010_03_18,
. . . . . . . . . . . . . . SouthCarolina02E3_2010_03_05
. . . . . . . . . . . . . . . . . . . . . . with 25R,
. . . . . . . . . . . . . . TexasJMS413_2010_02_03
. . . . . . . . . . . . . . . . . . . . . . with 25R,
. . . . . . . . . . . . . . TexasJMS391_2009_12_23
. . . . . . . . . . . . . . . . . . . . . . with 25R,
. . . . . . . . . . . . . . IndiaPune10604_2009_09],
. . . . . . . . 214R,
. . . . . . . . syn428L)
. . . . England734_2009_10 (
. . . . . . . . syn50V [GDWujiang51_2010_03_18,
. . . . . . . . . . . . . . SouthCarolina02E3_2010_03_05
. . . . . . . . . . . . . . . . . . . . . . with 25R,
. . . . . . . . . . . . . . TexasJMS413_2010_02_03
. . . . . . . . . . . . . . . . . . . . . . with 25R,
. . . . . . . . . . . . . . TexasJMS391_2009_12_23
. . . . . . . . . . . . . . . . . . . . . . with 25R,
. . . . . . . . . . . . . . IndiaPune10604_2009_09])
. . . . Eng662_2009_08 (
. . . . . . . . 25R [SouthCarolina02E3_2010_03_05
. . . . . . . . . . . . . . . .. . . . with syn50V,
. . . . . . . . . . . TexasJMS413_2010_02_03
. . . . . . . . . . . . . . . .. . . . with syn50V,
. . . . . . . . . . . TexasJMS391_2009_12_23
. . . . . . . . . . . . . . . .. . . . with syn50V,
. . . . . . . . . . . Texas extensive (10 more),
. . . . . . . . . . . Afghanistan (2),
. . . . . . . . . . . Russia149_2009_11_01_xL,
. . . . . . . . . . . Utah42_2009_07_24
. . . . . . . . . . . . . . . with 225G / 225N],
. . . . . . . . syn116R [NY6530_2010_02_21,
. . . . . . . . . . . . . . swOsaka1_2009_10,
. . . . . . . . . . . . . . Texas45071344_2009_09_07,
. . . . . . . . . . . . . . Portugal (2) 2009_08_19,
. . . . . . . . . . . . . . Military (30) 2009_08 to 2009_12,
. . . . . . . . . . . . . . Australia as early as 2009_07 (3),
. . . . . . . . . . . . . . SingTLL53_2009_06_14,
. . . . . . . . . . . . . . Columbia 2009_06 (2),
. . . . . . . . . . . . . . WiscD1606_2009_05_03],
. . . . . . . . syn348V [JapanAF2284_2009_11_27,
. . . . . . . . . . . . . . Frankfurt301_2009_11_23,
. . . . . . . . . . . . . . Ankara27_2009_11_11,
. . . . . . . . . . . . . . Yaroslavl_CHMV_2009_11_10_f with 225G,
. . . . . . . . . . . . . . Yakutsk_EAV_2009_11_18,
. . . . . . . . . . . . . . Thailand (24) as late as 2009_09_25,
. . . . . . . . . . . . . . BZ_SaoPaulo53823_2009_08_01_f,
. . . . . . . . . . . . . . Yakutsk_EAV_2009_11_18,
. . . . . . . . . . . . . . IndiaPune6196_2009_08,
. . . . . . . . . . . . . . IndiaDhule9433_2009_08,
. . . . . . . . . . . . . . IndiaPune807_2009_07,
. . . . . . . . . . . . . . PNG_PortMoresby2005_2009_07_08,
. . . . . . . . . . . . . . MoroccoRabat72_2009_07_02,
. . . . . . . . . . . . . . Slovenia2322_2009_07_01,
. . . . . . . . . . . . . . SingON442_2009_06_25,
. . . . . . . . . . . . . . ThailandCUB5_2009_06_13],
. . . . . . . . 494K [Indiana21_2009_12_10,
. . . . . . . . . . . . NewMexico07_2009_10_18,
. . . . . . . . . . . . NY5755_2009_10_01,
. . . . . . . . . . . . Ankara12_2009_09,
. . . . . . . . . . . . Ankara16_2009_09,
. . . . . . . . . . . . Ankara29_2009,
. . . . . . . . . . . . NY4568_2009_07_09,
. . . . . . . . . . . . NY4500_2009_07_01,
. . . . . . . . . . . . RhodeIsland04_2009_06_01])
Three American sequences are on file from December 2009 to March 2010 that accumulate both the 25R of Eng662_2009_08 and the syn50V of IndiaPune10604_2009_09. A pattern of attraction or permissiveness is suggested.
- SouthCarolina02E3_2010_03_05
- TexasJMS413_2010_02_03
- TexasJMS391_2009_12_23
India is in the grip of a post-pandemic acceleration of death due to burgeoning caseloads and an apparent change in viral behaviour. They have experience, foresight, materials and initiative, but the disease is overcoming the system and killing the citizens. The health purveyors are doing everything by the book, but the chapters are out-dated apparently.
What will we find in those sequences? How may we adapt our methods and materials to assist the families in India? When will those viral changes be adopted in other countries?
Pondering is excellent, but action is better.
The sequences will tell the truth and provide a footing to act. Please publish the sequences from May to August 2010.
Supporting / Related Sequences
. . . . India3725_2010_04_03 (
. . . . . . . . 117T,
. . . . . . . . syn167S,
. . . . . . . . 186P,
. . . . . . . . syn474C,
. . . . . . . . syn526S [SwedenMalmoe2_2010_05_07])
. . . . IndiaPune10604_2009_09 (
. . . . . . . . syn2N [UkrSumy797_2009_11_13_f,
. . . . . . . . . . . . . MongoliaJP5756_2009_10_15,
. . . . . . . .. . . . . SingON2416_2009_12_15],
. . . . . . . . syn50V [TexasJMS391_2009_12_23,
. . . . . . . . . . . . . . TexasJMS413_2009_02_03,
. . . . . . . . . . . . . . SouthCarolina02E3_2010_03_05],
. . . . . . . . syn178V (GTt) [NewHampshire02E3_2010_02_19 (GTa)],
. . . . . . . . 206S,
. . . . . . . . 296H,
. . . . . . . . syn348V [Yaroslavl_CHMV_2009_11_10_f with 225G,
. . . . . . . . . . . . . . Yakutsk_EAV_2009_11_18,
. . . . . . . . . . . . . . BZ_SaoPaulo53823_2009_08_01_f,
. . . . . . . . . . . . . . Eng662_2009_08],
. . . . . . . . syn485G [Nebraska 01_2010_01_28,
. . . . . . . . . . . . . . Orenburg2974_2009_11_16_xL,
. . . . . . . . . . . . . . NagasakiHA10_22_2010_03_01])
. . . . IndiaPune6196_2009_08 (
. . . . . . . . #12E,
. . . . . . . . syn2N [UkrSumy797_2009_11_13_f,
. . . . . . . . . . . . . MongoliaJP5756_2009_10_15,
. . . . . . . .. . . . . SingON2416_2009_12_15],
. . . . . . . . syn152I [NY6939_2009_12_11,
. . . . . . . . . . . . . . . tkOntarioFAV117_1C_2009_12_07,
. . . . . . . . . . . . . . . CalifVRDL115_2009_12_04,
. . . . . . . . . . . . . . . England1051_2009_12,
. . . . . . . . . . . . . . . England1050_2009_12,
. . . . . . . . . . . . . . . Scotland103_2009_12,
. . . . . . . . . . . . . . . England94800096_2009_11,
. . . . . . . . . . . . . . . ItalyAncona451_2009_11_27_f,
. . . . . . . . . . . . . . . NY6607_2009_11_24,
. . . . . . . . . . . . . . . CalifVRDL107_2009_11_15,
. . . . . . . . . . . . . . . CalifVRDL101_2009_11_05,
. . . . . . . . . . . . . . . DC_114_2009_11_04,
. . . . . . . . . . . . . . . Calif_SD35_2009_10_26,
. . . . . . . . . . . . . . . NY5447_2009_10_23,
. . . . . . . . . . . . . . . CalifVRDL84_2009_10_09,
. . . . . . . . . . . . . . . CalifVRDL87_2009_10_09,
. . . . . . . . . . . . . . . IndiaDhule9433_2009_08,
. . . . . . . . . . . . . . . SantoDomingoWR1057N_2009_07_02,
. . . . . . . . . . . . . . . SantoDomingoWR1058N_2009_07_02,
. . . . . . . . . . . . . . . SantoDomingoWR1059N_2009_06_30],
. . . . . . . . 206S,
. . . . . . . . 296H,
. . . . . . . . syn300P (CCt) [H5N1, H6N1, H7N3, H7N7],
. . . . . . . . . . . . . . . . . [Virginia24_2009_06_03 (CCt),
. . . . . . . . . . . . . . . . . NY0352_2009_12_27 (CCt),
. . . . . . . . . . . . . . . . . IllinoisAF2223_2009_12_18 (CCt),
. . . . . . . . . . . . . . . . . SingON2416_2009_12_15 (CCa),
. . . . . . . . . . . . . . . . . Vietnam2043_2009_12_01_TmX (CCa),
. . . . . . . . . . . . . . . . . HunanFur129_2010_01_13 (CCa),
. . . . . . . . . . . . . . . . . Slovenia5613_2009_12 (CCa),
. . . . . . . . . . . . . . . . . Minnesota40_2009_11_19 (CCa) w syn252V],
. . . . . . . . 342R,
. . . . . . . . syn348V [Yaroslavl_CHMV_2009_11_10_f with 225G,
. . . . . . . . . . . . . . Yakutsk_EAV_2009_11_18,
. . . . . . . . . . . . . . BZ_SaoPaulo53823_2009_08_01_f,
. . . . . . . . . . . . . . Eng662_2009_08],
. . . . . . . . syn355H [H2, H5N1, H6N1],
. . . . . . . . . . . . . . [GDLiwan1170_2010_03_14,
. . . . . . . . . . . . . . NY2963_2010_01_22
. . . . . . . . . . . . . .. . . . . . . . with 50E, 100N,
. . . . . . . . . . . . . . ItalyAncona508_2009_12_31
. . . . . . . . . . . . . .. . . . . . . . with syn181G,
. . . . . . . . . . . . . . Yamagata803_2009_12_21,
. . . . . . . . . . . . . . Astrakhan_CHRM_2009_11_24_xL_f,
. . . . . . . . . . . . . . MoscowOb_ZNF_2009_11_24_xL_f,
. . . . . . . . . . . . . . Ivanovo_STV1_2009_11_21
. . . . . . . . . . . . . .. . . . . . . . with 225G,
. . . . . . . . . . . . . . FloridaPensacola107_2009_11_12,
. . . . . . . . . . . . . . MoscowOb_STV_2009_11_09_f
. . . . . . . . . . . . . .. . . . . . . . with 225N,
. . . . . . . . . . . . . . swTaiwanTD4119B2_2009_11_04,
. . . . . . . . . . . . . . ArgentinaHNRG44_2009_06_30
. . . . . . . . . . . . . .. . . . . . . . with 71G,
. . . . . . . . . . . . . . ArgentinaHNRG39_2009_06_23
. . . . . . . . . . . . . .. . . . . . . . with 259T,
. . . . . . . . . . . . . . WiscD0589_2009_06_03
. . . . . . . . . . . . . .. . . . . . . . with syn178V])
. . . . IndiaDhule9433_2009_08 (
. . . . . . . . #12E,
. . . . . . . . syn2N [UkrSumy797_2009_11_13_f,
. . . . . . . . . . . . . MongoliaJP5756_2009_10_15,
. . . . . . . . . . . . . SingON2416_2009_12_15,
. . . . . . . . . . . . . IndiaPune10604_2009_09, et al],
. . . . . . . . syn152I [NY6939_2009_12_11,
. . . . . . . . . . . . . . . tkOntarioFAV117_1C_2009_12_07,
. . . . . . . . . . . . . . . CalifVRDL115_2009_12_04,
. . . . . . . . . . . . . . . England1051_2009_12,
. . . . . . . . . . . . . . . England1050_2009_12,
. . . . . . . . . . . . . . . Scotland103_2009_12,
. . . . . . . . . . . . . . . England94800096_2009_11,
. . . . . . . . . . . . . . . ItalyAncona451_2009_11_27_f,
. . . . . . . . . . . . . . . NY6607_2009_11_24,
. . . . . . . . . . . . . . . CalifVRDL107_2009_11_15,
. . . . . . . . . . . . . . . CalifVRDL101_2009_11_05,
. . . . . . . . . . . . . . . DC_114_2009_11_04,
. . . . . . . . . . . . . . . Calif_SD35_2009_10_26,
. . . . . . . . . . . . . . . NY5447_2009_10_23,
. . . . . . . . . . . . . . . CalifVRDL84_2009_10_09,
. . . . . . . . . . . . . . . CalifVRDL87_2009_10_09,
. . . . . . . . . . . . . . . IndiaPune6196_2009_08,
. . . . . . . . . . . . . . . SantoDomingoWR1057N_2009_07_02,
. . . . . . . . . . . . . . . SantoDomingoWR1058N_2009_07_02,
. . . . . . . . . . . . . . . SantoDomingoWR1059N_2009_06_30],
. . . . . . . . 176I,
. . . . . . . . 205W,
. . . . . . . . 206S,
. . . . . . . . 252L (cTG) [Maryland03_2010_01_13 (tTG),
. . . . . . . . . . . . . . . Guangdong2361_2009_11_25 (tTG)],
. . . . . . . . 296H,
. . . . . . . . syn348V [Yaroslavl_CHMV_2009_11_10_f with 225G,
. . . . . . . . . . . . . . Yakutsk_EAV_2009_11_18,
. . . . . . . . . . . . . . BZ_SaoPaulo53823_2009_08_01_f,
. . . . . . . . . . . . . . Eng662_2009_08],
. . . . . . . . syn386I [1918, Unique to PF11])
. . . . IndiaPune807_2009_07 (
. . . . . . . . #12E,
. . . . . . . . syn2N [UkrSumy797_2009_11_13_f ,
. . . . . . . . . . . . . MongoliaJP5756_2009_10_15,
. . . . . . . .. . . . . SingON2416_2009_12_15],
. . . . . . . . 100Q [Unique to PF11],
. . . . . . . . syn104L [CalifVRDL132_2009_12_30,
. . . . . . . . . . . . . . . Texas45122538_2009_09_12,
. . . . . . . . . . . . . . . WiscD0410_2009_09_24,
. . . . . . . . . . . . . . . WiscD1355_2009_09_21],
. . . . . . . . 206S,
. . . . . . . . 296H,
. . . . . . . . syn348V [Yaroslavl_CHMV_2009_11_10_f with 225G,
. . . . . . . . . . . . . . Yakutsk_EAV_2009_11_18,
. . . . . . . . . . . . . . BZ_SaoPaulo53823_2009_08_01_f,
. . . . . . . . . . . . . . Eng662_2009_08],
. . . . . . . . 461E [Unique to PF11]),
. . . . England1048_2009_12 (
. . . . . . . . 214R,
. . . . . . . . 225E,
. . . . . . . . 324I)
. . . . England1051_2009_12 (
. . . . . . . . syn10Y,
. . . . . . . . 35I,
. . . . . . . . syn152I [NY6939_2009_12_11,
. . . . . . . . . . . . . . . tkOntarioFAV117_1C_2009_12_07,
. . . . . . . . . . . . . . . CalifVRDL115_2009_12_04,
. . . . . . . . . . . . . . . England1050_2009_12,
. . . . . . . . . . . . . . . Scotland103_2009_12,
. . . . . . . . . . . . . . . England94800096_2009_11,
. . . . . . . . . . . . . . . ItalyAncona451_2009_11_27_f,
. . . . . . . . . . . . . . . NY6607_2009_11_24,
. . . . . . . . . . . . . . . CalifVRDL107_2009_11_15,
. . . . . . . . . . . . . . . CalifVRDL101_2009_11_05,
. . . . . . . . . . . . . . . DC_114_2009_11_04,
. . . . . . . . . . . . . . . Calif_SD35_2009_10_26,
. . . . . . . . . . . . . . . NY5447_2009_10_23,
. . . . . . . . . . . . . . . CalifVRDL84_2009_10_09,
. . . . . . . . . . . . . . . CalifVRDL87_2009_10_09,
. . . . . . . . . . . . . . . IndiaPune6196_2009_08,
. . . . . . . . . . . . . . . IndiaDhule9433_2009_08,
. . . . . . . . . . . . . . . SantoDomingoWR1057N_2009_07_02,
. . . . . . . . . . . . . . . SantoDomingoWR1058N_2009_07_02,
. . . . . . . . . . . . . . . SantoDomingoWR1059N_2009_06_30],
. . . . . . . . 206S,
. . . . . . . . syn219I,
. . . . . . . . syn254P,
. . . . . . . . syn276H,
. . . . . . . . syn456L,
. . . . . . . . 463V,
. . . . . . . . 502K [Ukraine],
. . . . . . . . 523A)
. . . . SouthCarolina02E3_2010_03_05 (
. . . . . . . . 25R [Utah42_2009_07_24 with 225G / 225N,
. . . . . . . . . . . Texas extensive (12),
. . . . . . . . . . . Afghanistan (2),
. . . . . . . . . . . Russia149_2009_11_01_xL],
. . . . . . . . syn50V [TexasJMS391_2009_12_23,
. . . . . . . . . . . . . TexasJMS413_2009_02_03,
. . . . . . . . . . . . . IndiaPune10604_2009_09],
. . . . . . . . 130E (GAa) [1918],
. . . . . . . . . . . . [Netherlands2243_2009_11_17_xL (GAg) mix
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . with 158E, 225G,
. . . . . . . . . . . . Iraq8531_2009_09_08_xL (GAa) with 131L,
. . . . . . . . . . . . Guangdong0872_2009_12_27 (GAa),
. . . . . . . . . . . . SingTLL52_2009_06_14 (GAa),
. . . . . . . . . . . . swAlbertaOTH_33_23_2009_05_03 (GAa)],
. . . . . . . . 206T)
. . . . TexasJMS413_2010_02_03 (
. . . . . . . . 25R,
. . . . . . . . syn50V,
. . . . . . . . syn84E)
. . . . TexasJMS391_2009_12_23 (
. . . . . . . . 25R,
. . . . . . . . syn50V,
. . . . . . . . syn84E,
. . . . . . . . syn374A)
. . . . NY2963_2010_01_22 (
. . . . . . . . 50E,
. . . . . . . . 100N,
. . . . . . . . syn270I,
. . . . . . . . syn291T,
. . . . . . . . syn355H,
. . . . . . . . 377K)
. . . . FloridaPensacola107_2009_11_12 (
. . . . . . . . 35I,
. . . . . . . . syn338G,
. . . . . . . . syn355H,
. . . . . . . . syn456L)
. . . . WiscD0589_2009_06_03 (
. . . . . . . . syn36L,
. . . . . . . . syn178V,
. . . . . . . . 193N,
. . . . . . . . syn355H)
. . . . Indiana21_2009_12_01 (
. . . . . . . . syn12A,
. . . . . . . . syn177L,
. . . . . . . . syn193S,
. . . . . . . . 212E mix,
. . . . . . . . 313K,
. . . . . . . . syn346G,
. . . . . . . . 359G,
. . . . . . . . 377K,
. . . . . . . . 494K)
. . . . IllinoisAF2223_2009_12_18 (
. . . . . . . . syn34N,
. . . . . . . . syn300P (CCt),
. . . . . . . . 377K,
. . . . . . . . HA truncated after aa386)
. . . . CalifVRDL107_2009_11_15 (
. . . . . . . . 35I,
. . . . . . . . 39N,
. . . . . . . . syn152I,
. . . . . . . . 206S,
. . . . . . . . syn219I,
. . . . . . . . syn276H,
. . . . . . . . syn456L,
. . . . . . . . 463V,
. . . . . . . . 523A)
. . . . CalifVRDL115_2009_12_04 (
. . . . . . . . 35I,
. . . . . . . . 77N,
. . . . . . . . syn152I,
. . . . . . . . 206S,
. . . . . . . . syn219I,
. . . . . . . . syn276H,
. . . . . . . . syn456L,
. . . . . . . . 463V,
. . . . . . . . 523A)
. . . . Malmoe2_2010_05_07 (
. . . . . . . . 89G,
. . . . . . . . syn108L [tn],
. . . . . . . . syn159N,
. . . . . . . . 206T,
. . . . . . . . 259T [ArgentinaHNRG39_2009_06_23
. . . . . . . . . . . . . . . . . . . . with syn355H],
. . . . . . . . syn280T [1918, WSN33],
. . . . . . . . syn526S [India3725_2010_04_03])
. . . . ItalyAncona508_2009_12_31 (
. . . . . . . . syn172K,
. . . . . . . . syn181G,
. . . . . . . . syn239P,
. . . . . . . . syn355H,
. . . . . . . . 373H)
. . . . GDLiwan1170_2010_03_14 (
. . . . . . . . 131P,
. . . . . . . . 202A,
. . . . . . . . 271T,
. . . . . . . . 298V,
. . . . . . . . syn355H,
. . . . . . . . 375F)
. . . . tkOntarioFAV117_1C_2009_12_07 (
. . . . . . . . 35I [H5N1],
. . . . . . . . syn55L,
. . . . . . . . syn152I,
. . . . . . . . 186P,
. . . . . . . . syn205G,
. . . . . . . . syn219I,
. . . . . . . . syn276H [1918, S5],
. . . . . . . . syn456L,
. . . . . . . . 463V,
. . . . . . . . syn486T,
. . . . . . . . 523A)
Please refer to additional studies for further genetic analyses, including the survey on amino acid revisions potentially related to Vaccine Escape. A hyper-morphic, TamiFlu-resistant sequence from the state of Washington in Spring 2010 has recently been profiled with similar zoonotic influences.
This analysis was fueled by puneri amti and funded with contributions from concerned families, including HOD, BMS, MJV and CSB.
* Rare, not Random
4,069 People Began TamiFlu Treatment on Monday in Pune India
If someone had told the citizens that the virus would be post-pandemic on Thursday, they may have asked for a treatment deferral . . . unless they trusted their own eyes. No press release can revise the rise of a IDEARRV disease like the ΣPF11 influenza reservoir.
The facts speak for themselves.
On Monday, 2010-08-09, more than 4,000 citizens were placed on TamiFlu treatment in the city of Pune, India. 83 deaths were recorded from pre-post-pandemic influenza for the prior 7 days in India.
For the country of India, the weekly average confirmed Influenza death count over the past 14 months is slightly above 30 deaths per week. The fatality count from the past week of 83 is 2.7 times the average rate, a substantial acceleration. The Case Fatality Rate varies from 8.8% to 12.1% in the city/district based on the source of data and date bounding. Roughly 1 in 10 people with a confirmed influenza test die in India.
More than 75% of the deaths are in the 20-49 year old age bracket according to the raw data we have been able to reference, with reports from others as low as 70%. Years of Life Lost calculations defy all "normal" influenza trends. Traditional influenza has a CFR of less than half a percent and more than 98% of that half percent are over 65 or under 2 years old. These numbers from India in 2010 are not suggestive of a post-pandemic status.
Perhaps we should all just re-base now that we have read the press releases and settle ourselves into this post-pandemic era.
Step 1. We could call 83 deaths per week the new "normal" and post that idea as the rate for "seasonal" influenza. Our forms and percentages will then be quite less concerning to the public. Then we could take a note from the public health textbooks and "estimate using the most advanced models" a normal CFR and game the model variables until we evaluate to the current 8.8% CFR of India.
Step 2. Combine the power of the press with the power of the "expert" credential, even perhaps a committee of experts? In a few pen strokes and an hour here and there behind a microphone, the public would be assuaged and all could return to "business as usual".
Or we could hear the public whose health is suffering, read the data and then tell the truth.
Though we'd like to see the sequences from these fatal cases that are currently accelerating throughout India, a review of the data on file will allow insight into the building / budding process of a pandemic virus into and out of a monsoon climate. An array of FlightPaths may be detected that led to Hydra strains downstream in time. We are under no uncertainty that the viral reservoir will follow a similar route this year.
India, last year, was a testing field for PF11. In a nutshell, the sub-continent had a depth of uptake from Asia and North America that transformed and promoted to Europe and then returned to the United States. That pathway is a generalisation / characterisation and is not comprehensive. Suspicions do lead to a repeat of last year.
Has, perhaps, the 225G on the HA and the 275Y on the NA become more substantial in India after travelling through the world? Is HA 225N playing a role in the more rapid expirations, while cross-linked 225G causes the lingering 3-5 day, ICU-bound feats of ultimate exhaustion? Is a deep, immune escape Hydra carrying HA 165N and 230I at work in the districts showing a 20-29% Case Fatality Rate?
We watch as vaccinated doctors are admitted to critical care wards, as hospitals with advanced experience and materials lose patients daily to Influenza, even upon using immediate TamiFlu blanketing. Reports of fatalities associated with caregivers, including doctors, are demonstrated in multiple geographies.
Review the sequences that have been made available. See the truth.
. . . . India3725_2010_04_03 (
. . . . . . . . 117T,
. . . . . . . . syn167S,
. . . . . . . . 186P,
. . . . . . . . syn474C,
. . . . . . . . syn526S [Malmoe2_2010_05_07 with 89G])
. . . . IndiaPune10278_2009_09 (
. . . . . . . . syn48R [Norway1359_2009_05_16,
. . . . . . . . . . . . . . UkrZakarpatska830_2009_11_12_f, et al],
. . . . . . . . syn131S [Russia, Afghan, Kenya,
. . . . . . . . . . . . . . NY6943_2009_12_07_xL,
. . . . . . . . . . . . . . Wisconsin, California,
. . . . . . . . . . . . . . Nicaragua, Greece],
. . . . . . . . 206T,
. . . . . . . . 225G,
. . . . . . . . syn413K [H9N2],
. . . . . . . . 454N [H7N3, H7N7, H9N2]
. . . . . . . . . . . . . . [IndiaPune9355_2009_08 with 225G,
. . . . . . . . . . . . . . IndiaBlore236_2009_06_xL with 226R,
. . . . . . . . . . . . . . SouthCarolina18_2009_09_16_VxX,
. . . . . . . . . . . . . . FL_Pen210_2009_11_10],
. . . . . . . . 550T [Unique to India])
. . . . IndiaPune10604_2009_09 (
. . . . . . . . syn2N [UkrSumy797_2009_11_13_f,
. . . . . . . . . . . . . MongoliaJP5756_2009_10_15,
. . . . . . . .. . . . . SingON2416_2009_12_15],
. . . . . . . . syn50V [TexasJMS391_2009_12_23,
. . . . . . . . . . . . . . TexasJMS413_2009_02_03,
. . . . . . . . . . . . . . SouthCarolina02E3_2010_03_05],
. . . . . . . . syn178V (GTt) [NewHampshire02E3_2010_02_19 (GTa)],
. . . . . . . . 206S,
. . . . . . . . 296H,
. . . . . . . . syn348V [Yaroslavl_CHMV_2009_11_10_f with 225G,
. . . . . . . . . . . . . . Yakutsk_EAV_2009_11_18,
. . . . . . . . . . . . . . BZ_SaoPaulo53823_2009_08_01_f,
. . . . . . . . . . . . . . Eng662_2009_08],
. . . . . . . . syn485G [Nebraska 01_2010_01_28,
. . . . . . . . . . . . . . Orenburg2974_2009_11_16_xL,
. . . . . . . . . . . . . . NagasakiHA10_22_2010_03_01])
. . . . IndiaDelhi3704_2009_09 (
. . . . . . . . syn44L,
. . . . . . . . syn106E,
. . . . . . . . syn125S,
. . . . . . . . syn159N,
. . . . . . . . 206T,
. . . . . . . . syn297N,
. . . . . . . . syn413K)
. . . . IndiaNsk10348_2009_09 (
. . . . . . . . #12E,
. . . . . . . . syn33V,
. . . . . . . . 206S,
. . . . . . . . 225G,
. . . . . . . . 296H,
. . . . . . . . syn406R,
. . . . . . . . syn439D)
. . . . IndiaJalna9436_2009_08_30 (
. . . . . . . . 8V [Yaroslavl_KMP_2009_08_25,
. . . . . . . . . . NY7216_2009_12_21 with 225G,
. . . . . . . . . . Utah32_2009_10_14],
. . . . . . . . syn147F [H3N8 Avian, H4, H5, H6, H11],
. . . . . . . . . . . . . . [Yaroslavl_KMP_2009_08_25,
. . . . . . . . . . . . . . IndiaPune21115_2009_12,
. . . . . . . . . . . . . . Athens943_2009_06_12,
. . . . . . . . . . . . . . CalifVRDL99_2009_11_05,
. . . . . . . . . . . . . . Texas44301765_2009_08_30],
. . . . . . . . syn210S,
. . . . . . . . 226R)
. . . . IndiaDelhi3610_2009_08 (
. . . . . . . . syn125S,
. . . . . . . . 157E,
. . . . . . . . 206T,
. . . . . . . . syn294P,
. . . . . . . . syn464G)
. . . . IndiaMum9312_2009_08 (
. . . . . . . . 208K,
. . . . . . . . 225G,
. . . . . . . . syn385V)
. . . . IndiaPune6196_2009_08 (
. . . . . . . . #12E,
. . . . . . . . syn2N [UkrSumy797_2009_11_13_f,
. . . . . . . . . . . . . MongoliaJP5756_2009_10_15,
. . . . . . . .. . . . . SingON2416_2009_12_15],
. . . . . . . . syn152I,
. . . . . . . . 206S,
. . . . . . . . 296H,
. . . . . . . . syn300P (CCt) [H5N1, H6N1, H7N3, H7N7],
. . . . . . . . . . . . . . . . . [Virginia24_2009_06_03 (CCt),
. . . . . . . . . . . . . . . . . NY0352_2009_12_27 (CCt),
. . . . . . . . . . . . . . . . . SingON2416_2009_12_15 (CCa),
. . . . . . . . . . . . . . . . . Vietnam2043_2009_12_01_TmX (CCa),
. . . . . . . . . . . . . . . . . HunanFur129_2010_01_13 (CCa),
. . . . . . . . . . . . . . . . . Slovenia5613_2009_12 (CCa),
. . . . . . . . . . . . . . . . . Minnesota40_2009_11_19 (CCa) w syn252V],
. . . . . . . . 342R,
. . . . . . . . syn348V [Yaroslavl_CHMV_2009_11_10_f with 225G,
. . . . . . . . . . . . . . Yakutsk_EAV_2009_11_18,
. . . . . . . . . . . . . . BZ_SaoPaulo53823_2009_08_01_f,
. . . . . . . . . . . . . . Eng662_2009_08],
. . . . . . . . syn355H [H2, H5N1, H6N1],
. . . . . . . . . . . . . . [MoscowOb_ZNF_2009_11_24_xL_f,
. . . . . . . . . . . . . . MoscowOb_STV_2009_11_09_f with 225N,
. . . . . . . . . . . . . . Ivanovo_STV1_2009_11_21 with 225G,
. . . . . . . . . . . . . . WiscD0589_2009_06_03])
. . . . IndiaPune9355_2009_08 (
. . . . . . . . #10T,
. . . . . . . . syn#4Y [GermanyBY74_2009 with 225G & 226R,
. . . . . . . . . . . . . FL_Pensacola40_2009_11_09],
. . . . . . . . 206T,
. . . . . . . . 225G,
. . . . . . . . syn372Q [H2, H3N8, H4, H5, H6, H7N3, H7N7, H9N2, H11]
. . . . . . . . . . . . . . [IndiaBlore236_2009_06_xL with 226R,
. . . . . . . . . . . . . . Ulyanovsk_SHTA_2009_10_31_f_225N,
. . . . . . . . . . . . . . Orenburg2974_2009_11_16_xL,
. . . . . . . . . . . . . . Russia fatal extensive,
. . . . . . . . . . . . . . swIowa35572_2009_12_16,
. . . . . . . . . . . . . . NagasakiHA10_22_2010_03_01],
. . . . . . . . 373K,
. . . . . . . . syn413K [H9N2],
. . . . . . . . 454N [H7N3, H7N7, H9N2]
. . . . . . . . . . . . . [IndiaBlore236_2009_06 with 226R,
. . . . . . . . . . . . . SouthCarolina18_2009_09_16_VxX,
. . . . . . . . . . . . . FL_Pen210_2009_11_10],
. . . . . . . . 550T [Unique to India])
. . . . IndiaDhule9433_2009_08 (
. . . . . . . . #12E,
. . . . . . . . syn2N [UkrSumy797_2009_11_13_f,
. . . . . . . . . . . . . MongoliaJP5756_2009_10_15,
. . . . . . . . . . . . . SingON2416_2009_12_15,
. . . . . . . . . . . . . IndiaPune10604_2009_09, et al],
. . . . . . . . syn152I,
. . . . . . . . 176I,
. . . . . . . . 205W,
. . . . . . . . 206S,
. . . . . . . . 252L (cTG) [Maryland03_2010_01_13 (tTG),
. . . . . . . . . . . . . . . Guangdong2361_2009_11_25 (tTG)],
. . . . . . . . 296H,
. . . . . . . . syn348V [Yaroslavl_CHMV_2009_11_10_f with 225G,
. . . . . . . . . . . . . . Yakutsk_EAV_2009_11_18,
. . . . . . . . . . . . . . BZ_SaoPaulo53823_2009_08_01_f,
. . . . . . . . . . . . . . Eng662_2009_08],
. . . . . . . . syn386I [1918, Unique to PF11])
. . . . IndiaBlore310_2009_07 (
. . . . . . . . syn105R,
. . . . . . . . syn112S,
. . . . . . . . 206T,
. . . . . . . . syn477T)
. . . . IndiaPune807_2009_07 (
. . . . . . . . #12E,
. . . . . . . . syn2N [UkrSumy797_2009_11_13_f ,
. . . . . . . . . . . . . MongoliaJP5756_2009_10_15,
. . . . . . . .. . . . . SingON2416_2009_12_15],
. . . . . . . . 100Q [Unique to PF11],
. . . . . . . . syn104L [CalifVRDL132_2009_12_30,
. . . . . . . . . . . . . . . Texas45122538_2009_09_12,
. . . . . . . . . . . . . . . WiscD0410_2009_09_24,
. . . . . . . . . . . . . . . WiscD1355_2009_09_21],
. . . . . . . . 206S,
. . . . . . . . 296H,
. . . . . . . . syn348V [Yaroslavl_CHMV_2009_11_10_f with 225G,
. . . . . . . . . . . . . . Yakutsk_EAV_2009_11_18,
. . . . . . . . . . . . . . BZ_SaoPaulo53823_2009_08_01_f,
. . . . . . . . . . . . . . Eng662_2009_08],
. . . . . . . . 461E [Unique to PF11])
. . . . IndiaBlore236_2009_06_xL (
. . . . . . . . 226R,
. . . . . . . . syn372Q [H2, H3N8, H4, H5, H6, H7N3, H7N7, H9N2, H11]
. . . . . . . . . . . . . . [IndiaPune9355_2009_08 with 225G,
. . . . . . . . . . . . . . Ulyanovsk_SHTA_2009_10_31_f_225N,
. . . . . . . . . . . . . . Orenburg2974_2009_11_16_xL,
. . . . . . . . . . . . . . Russia fatal extensive,
. . . . . . . . . . . . . . swIowa35572_2009_12_16,
. . . . . . . . . . . . . . NagasakiHA10_22_2010_03_01]),
. . . . . . . . syn413K [H9N2],
. . . . . . . . 454N [H7N3, H7N7, H9N2]
. . . . . . . . . . . . . . [IndiaPune9355_2009_08 with 225G,
. . . . . . . . . . . . . . SouthCarolina18_2009_09_16_VxX,
. . . . . . . . . . . . . . FL_Pen210_2009_11_10],
. . . . . . . . 550T [Unique to India])
. . . . IndiaHyderabad51_2009_05 (
. . . . . . . . 1T,
. . . . . . . . syn74S [swNC13598_2010_03_09_xL_f
. . . . . . . . . . . . . . . . . . with 15 HA + 4 NA revisions],
. . . . . . . . syn144A (GCc) [Rome632_2009_11_23 (GCg)],
. . . . . . . . 206S)
. . . . equineIndiaAhmedabad1_2009_04_26 (H3N8) (
. . . . . . . . syn211K [H3N8],
. . . . . . . . . . . . . . [MXinDRE50617_2009_11_01 with 225G,
. . . . . . . . . . . . . . Niedersachsen330_2009_07_20],
. . . . . . . . et al)
. . . . equineIndiaKatraJammu7_2008_06 (H3N8) (
. . . . . . . . syn211K [H3N8],
. . . . . . . . . . . . . . [MXinDRE50617_2009_11_01 with 225G,
. . . . . . . . . . . . . . Niedersachsen330_2009_07_20],
. . . . . . . . et al)
Please refer to additional studies for further genetic analyses, including the survey on amino acid revisions potentially related to Vaccine Escape. A hyper-morphic, TamiFlu-resistant sequence from the state of Washington in Spring 2010 has recently been profiled with similar zoonotic influences.
This analysis was fueled by baingan bharta and funded with contributions from concerned families, including HOD, BMS, MJV and CSB.
The facts speak for themselves.
On Monday, 2010-08-09, more than 4,000 citizens were placed on TamiFlu treatment in the city of Pune, India. 83 deaths were recorded from pre-post-pandemic influenza for the prior 7 days in India.
For the country of India, the weekly average confirmed Influenza death count over the past 14 months is slightly above 30 deaths per week. The fatality count from the past week of 83 is 2.7 times the average rate, a substantial acceleration. The Case Fatality Rate varies from 8.8% to 12.1% in the city/district based on the source of data and date bounding. Roughly 1 in 10 people with a confirmed influenza test die in India.
More than 75% of the deaths are in the 20-49 year old age bracket according to the raw data we have been able to reference, with reports from others as low as 70%. Years of Life Lost calculations defy all "normal" influenza trends. Traditional influenza has a CFR of less than half a percent and more than 98% of that half percent are over 65 or under 2 years old. These numbers from India in 2010 are not suggestive of a post-pandemic status.
Perhaps we should all just re-base now that we have read the press releases and settle ourselves into this post-pandemic era.
Step 1. We could call 83 deaths per week the new "normal" and post that idea as the rate for "seasonal" influenza. Our forms and percentages will then be quite less concerning to the public. Then we could take a note from the public health textbooks and "estimate using the most advanced models" a normal CFR and game the model variables until we evaluate to the current 8.8% CFR of India.
Step 2. Combine the power of the press with the power of the "expert" credential, even perhaps a committee of experts? In a few pen strokes and an hour here and there behind a microphone, the public would be assuaged and all could return to "business as usual".
Or we could hear the public whose health is suffering, read the data and then tell the truth.
- 4,000 on TamiFlu treatment in one day in one city
- 83 confirmed deaths in one week across India
- Post-Pandemic
Though we'd like to see the sequences from these fatal cases that are currently accelerating throughout India, a review of the data on file will allow insight into the building / budding process of a pandemic virus into and out of a monsoon climate. An array of FlightPaths may be detected that led to Hydra strains downstream in time. We are under no uncertainty that the viral reservoir will follow a similar route this year.
India, last year, was a testing field for PF11. In a nutshell, the sub-continent had a depth of uptake from Asia and North America that transformed and promoted to Europe and then returned to the United States. That pathway is a generalisation / characterisation and is not comprehensive. Suspicions do lead to a repeat of last year.
Has, perhaps, the 225G on the HA and the 275Y on the NA become more substantial in India after travelling through the world? Is HA 225N playing a role in the more rapid expirations, while cross-linked 225G causes the lingering 3-5 day, ICU-bound feats of ultimate exhaustion? Is a deep, immune escape Hydra carrying HA 165N and 230I at work in the districts showing a 20-29% Case Fatality Rate?
We watch as vaccinated doctors are admitted to critical care wards, as hospitals with advanced experience and materials lose patients daily to Influenza, even upon using immediate TamiFlu blanketing. Reports of fatalities associated with caregivers, including doctors, are demonstrated in multiple geographies.
Review the sequences that have been made available. See the truth.
. . . . India3725_2010_04_03 (
. . . . . . . . 117T,
. . . . . . . . syn167S,
. . . . . . . . 186P,
. . . . . . . . syn474C,
. . . . . . . . syn526S [Malmoe2_2010_05_07 with 89G])
. . . . IndiaPune10278_2009_09 (
. . . . . . . . syn48R [Norway1359_2009_05_16,
. . . . . . . . . . . . . . UkrZakarpatska830_2009_11_12_f, et al],
. . . . . . . . syn131S [Russia, Afghan, Kenya,
. . . . . . . . . . . . . . NY6943_2009_12_07_xL,
. . . . . . . . . . . . . . Wisconsin, California,
. . . . . . . . . . . . . . Nicaragua, Greece],
. . . . . . . . 206T,
. . . . . . . . 225G,
. . . . . . . . syn413K [H9N2],
. . . . . . . . 454N [H7N3, H7N7, H9N2]
. . . . . . . . . . . . . . [IndiaPune9355_2009_08 with 225G,
. . . . . . . . . . . . . . IndiaBlore236_2009_06_xL with 226R,
. . . . . . . . . . . . . . SouthCarolina18_2009_09_16_VxX,
. . . . . . . . . . . . . . FL_Pen210_2009_11_10],
. . . . . . . . 550T [Unique to India])
. . . . IndiaPune10604_2009_09 (
. . . . . . . . syn2N [UkrSumy797_2009_11_13_f,
. . . . . . . . . . . . . MongoliaJP5756_2009_10_15,
. . . . . . . .. . . . . SingON2416_2009_12_15],
. . . . . . . . syn50V [TexasJMS391_2009_12_23,
. . . . . . . . . . . . . . TexasJMS413_2009_02_03,
. . . . . . . . . . . . . . SouthCarolina02E3_2010_03_05],
. . . . . . . . syn178V (GTt) [NewHampshire02E3_2010_02_19 (GTa)],
. . . . . . . . 206S,
. . . . . . . . 296H,
. . . . . . . . syn348V [Yaroslavl_CHMV_2009_11_10_f with 225G,
. . . . . . . . . . . . . . Yakutsk_EAV_2009_11_18,
. . . . . . . . . . . . . . BZ_SaoPaulo53823_2009_08_01_f,
. . . . . . . . . . . . . . Eng662_2009_08],
. . . . . . . . syn485G [Nebraska 01_2010_01_28,
. . . . . . . . . . . . . . Orenburg2974_2009_11_16_xL,
. . . . . . . . . . . . . . NagasakiHA10_22_2010_03_01])
. . . . IndiaDelhi3704_2009_09 (
. . . . . . . . syn44L,
. . . . . . . . syn106E,
. . . . . . . . syn125S,
. . . . . . . . syn159N,
. . . . . . . . 206T,
. . . . . . . . syn297N,
. . . . . . . . syn413K)
. . . . IndiaNsk10348_2009_09 (
. . . . . . . . #12E,
. . . . . . . . syn33V,
. . . . . . . . 206S,
. . . . . . . . 225G,
. . . . . . . . 296H,
. . . . . . . . syn406R,
. . . . . . . . syn439D)
. . . . IndiaJalna9436_2009_08_30 (
. . . . . . . . 8V [Yaroslavl_KMP_2009_08_25,
. . . . . . . . . . NY7216_2009_12_21 with 225G,
. . . . . . . . . . Utah32_2009_10_14],
. . . . . . . . syn147F [H3N8 Avian, H4, H5, H6, H11],
. . . . . . . . . . . . . . [Yaroslavl_KMP_2009_08_25,
. . . . . . . . . . . . . . IndiaPune21115_2009_12,
. . . . . . . . . . . . . . Athens943_2009_06_12,
. . . . . . . . . . . . . . CalifVRDL99_2009_11_05,
. . . . . . . . . . . . . . Texas44301765_2009_08_30],
. . . . . . . . syn210S,
. . . . . . . . 226R)
. . . . IndiaDelhi3610_2009_08 (
. . . . . . . . syn125S,
. . . . . . . . 157E,
. . . . . . . . 206T,
. . . . . . . . syn294P,
. . . . . . . . syn464G)
. . . . IndiaMum9312_2009_08 (
. . . . . . . . 208K,
. . . . . . . . 225G,
. . . . . . . . syn385V)
. . . . IndiaPune6196_2009_08 (
. . . . . . . . #12E,
. . . . . . . . syn2N [UkrSumy797_2009_11_13_f,
. . . . . . . . . . . . . MongoliaJP5756_2009_10_15,
. . . . . . . .. . . . . SingON2416_2009_12_15],
. . . . . . . . syn152I,
. . . . . . . . 206S,
. . . . . . . . 296H,
. . . . . . . . syn300P (CCt) [H5N1, H6N1, H7N3, H7N7],
. . . . . . . . . . . . . . . . . [Virginia24_2009_06_03 (CCt),
. . . . . . . . . . . . . . . . . NY0352_2009_12_27 (CCt),
. . . . . . . . . . . . . . . . . SingON2416_2009_12_15 (CCa),
. . . . . . . . . . . . . . . . . Vietnam2043_2009_12_01_TmX (CCa),
. . . . . . . . . . . . . . . . . HunanFur129_2010_01_13 (CCa),
. . . . . . . . . . . . . . . . . Slovenia5613_2009_12 (CCa),
. . . . . . . . . . . . . . . . . Minnesota40_2009_11_19 (CCa) w syn252V],
. . . . . . . . 342R,
. . . . . . . . syn348V [Yaroslavl_CHMV_2009_11_10_f with 225G,
. . . . . . . . . . . . . . Yakutsk_EAV_2009_11_18,
. . . . . . . . . . . . . . BZ_SaoPaulo53823_2009_08_01_f,
. . . . . . . . . . . . . . Eng662_2009_08],
. . . . . . . . syn355H [H2, H5N1, H6N1],
. . . . . . . . . . . . . . [MoscowOb_ZNF_2009_11_24_xL_f,
. . . . . . . . . . . . . . MoscowOb_STV_2009_11_09_f with 225N,
. . . . . . . . . . . . . . Ivanovo_STV1_2009_11_21 with 225G,
. . . . . . . . . . . . . . WiscD0589_2009_06_03])
. . . . IndiaPune9355_2009_08 (
. . . . . . . . #10T,
. . . . . . . . syn#4Y [GermanyBY74_2009 with 225G & 226R,
. . . . . . . . . . . . . FL_Pensacola40_2009_11_09],
. . . . . . . . 206T,
. . . . . . . . 225G,
. . . . . . . . syn372Q [H2, H3N8, H4, H5, H6, H7N3, H7N7, H9N2, H11]
. . . . . . . . . . . . . . [IndiaBlore236_2009_06_xL with 226R,
. . . . . . . . . . . . . . Ulyanovsk_SHTA_2009_10_31_f_225N,
. . . . . . . . . . . . . . Orenburg2974_2009_11_16_xL,
. . . . . . . . . . . . . . Russia fatal extensive,
. . . . . . . . . . . . . . swIowa35572_2009_12_16,
. . . . . . . . . . . . . . NagasakiHA10_22_2010_03_01],
. . . . . . . . 373K,
. . . . . . . . syn413K [H9N2],
. . . . . . . . 454N [H7N3, H7N7, H9N2]
. . . . . . . . . . . . . [IndiaBlore236_2009_06 with 226R,
. . . . . . . . . . . . . SouthCarolina18_2009_09_16_VxX,
. . . . . . . . . . . . . FL_Pen210_2009_11_10],
. . . . . . . . 550T [Unique to India])
. . . . IndiaDhule9433_2009_08 (
. . . . . . . . #12E,
. . . . . . . . syn2N [UkrSumy797_2009_11_13_f,
. . . . . . . . . . . . . MongoliaJP5756_2009_10_15,
. . . . . . . . . . . . . SingON2416_2009_12_15,
. . . . . . . . . . . . . IndiaPune10604_2009_09, et al],
. . . . . . . . syn152I,
. . . . . . . . 176I,
. . . . . . . . 205W,
. . . . . . . . 206S,
. . . . . . . . 252L (cTG) [Maryland03_2010_01_13 (tTG),
. . . . . . . . . . . . . . . Guangdong2361_2009_11_25 (tTG)],
. . . . . . . . 296H,
. . . . . . . . syn348V [Yaroslavl_CHMV_2009_11_10_f with 225G,
. . . . . . . . . . . . . . Yakutsk_EAV_2009_11_18,
. . . . . . . . . . . . . . BZ_SaoPaulo53823_2009_08_01_f,
. . . . . . . . . . . . . . Eng662_2009_08],
. . . . . . . . syn386I [1918, Unique to PF11])
. . . . IndiaBlore310_2009_07 (
. . . . . . . . syn105R,
. . . . . . . . syn112S,
. . . . . . . . 206T,
. . . . . . . . syn477T)
. . . . IndiaPune807_2009_07 (
. . . . . . . . #12E,
. . . . . . . . syn2N [UkrSumy797_2009_11_13_f ,
. . . . . . . . . . . . . MongoliaJP5756_2009_10_15,
. . . . . . . .. . . . . SingON2416_2009_12_15],
. . . . . . . . 100Q [Unique to PF11],
. . . . . . . . syn104L [CalifVRDL132_2009_12_30,
. . . . . . . . . . . . . . . Texas45122538_2009_09_12,
. . . . . . . . . . . . . . . WiscD0410_2009_09_24,
. . . . . . . . . . . . . . . WiscD1355_2009_09_21],
. . . . . . . . 206S,
. . . . . . . . 296H,
. . . . . . . . syn348V [Yaroslavl_CHMV_2009_11_10_f with 225G,
. . . . . . . . . . . . . . Yakutsk_EAV_2009_11_18,
. . . . . . . . . . . . . . BZ_SaoPaulo53823_2009_08_01_f,
. . . . . . . . . . . . . . Eng662_2009_08],
. . . . . . . . 461E [Unique to PF11])
. . . . IndiaBlore236_2009_06_xL (
. . . . . . . . 226R,
. . . . . . . . syn372Q [H2, H3N8, H4, H5, H6, H7N3, H7N7, H9N2, H11]
. . . . . . . . . . . . . . [IndiaPune9355_2009_08 with 225G,
. . . . . . . . . . . . . . Ulyanovsk_SHTA_2009_10_31_f_225N,
. . . . . . . . . . . . . . Orenburg2974_2009_11_16_xL,
. . . . . . . . . . . . . . Russia fatal extensive,
. . . . . . . . . . . . . . swIowa35572_2009_12_16,
. . . . . . . . . . . . . . NagasakiHA10_22_2010_03_01]),
. . . . . . . . syn413K [H9N2],
. . . . . . . . 454N [H7N3, H7N7, H9N2]
. . . . . . . . . . . . . . [IndiaPune9355_2009_08 with 225G,
. . . . . . . . . . . . . . SouthCarolina18_2009_09_16_VxX,
. . . . . . . . . . . . . . FL_Pen210_2009_11_10],
. . . . . . . . 550T [Unique to India])
. . . . IndiaHyderabad51_2009_05 (
. . . . . . . . 1T,
. . . . . . . . syn74S [swNC13598_2010_03_09_xL_f
. . . . . . . . . . . . . . . . . . with 15 HA + 4 NA revisions],
. . . . . . . . syn144A (GCc) [Rome632_2009_11_23 (GCg)],
. . . . . . . . 206S)
. . . . equineIndiaAhmedabad1_2009_04_26 (H3N8) (
. . . . . . . . syn211K [H3N8],
. . . . . . . . . . . . . . [MXinDRE50617_2009_11_01 with 225G,
. . . . . . . . . . . . . . Niedersachsen330_2009_07_20],
. . . . . . . . et al)
. . . . equineIndiaKatraJammu7_2008_06 (H3N8) (
. . . . . . . . syn211K [H3N8],
. . . . . . . . . . . . . . [MXinDRE50617_2009_11_01 with 225G,
. . . . . . . . . . . . . . Niedersachsen330_2009_07_20],
. . . . . . . . et al)
Please refer to additional studies for further genetic analyses, including the survey on amino acid revisions potentially related to Vaccine Escape. A hyper-morphic, TamiFlu-resistant sequence from the state of Washington in Spring 2010 has recently been profiled with similar zoonotic influences.
This analysis was fueled by baingan bharta and funded with contributions from concerned families, including HOD, BMS, MJV and CSB.
Subscribe to:
Comments (Atom)
